A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) – A Protocol

R Bajwa; S. Goldberg; Veronika van der Wardt; C Burgon; C di Lorito; Maureen Godfrey; M. R. Dunlop; Pip Logan; Tahir Masud; John Gladman; Helen  Smith; Vicky Hood-Moore; Vicky Booth; Roshan das Nair; K. Pollock; Kavita Vedhara; Rhiannon Tudor Edwards; Carys Jones; Zoe Hoare; Andrew Brand; Rowan Harwood

doi:10.1186/s13063-019-3871-9

A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) – A Protocol

R Bajwa
, S. Goldberg
, Veronika van der Wardt
, C Burgon
, C di Lorito
, Maureen Godfrey
, M. R. Dunlop
, Pip Logan
, Tahir Masud
, John Gladman
, Helen Smith
, Vicky Hood-Moore
, Vicky Booth
, Roshan das Nair
, K. Pollock
, Kavita Vedhara
, Rhiannon Tudor Edwards
, Carys Jones
, Zoe Hoare
, Andrew Brand

Rowan Harwood

University of Nottingham
Nottingham University Hospitals NHS Trust

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

185 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

BACKGROUND: People with dementia progressively lose cognitive and functional abilities. Interventions promoting exercise and activity may slow decline. We developed a novel intervention to promote activity and independence and prevent falls in people with mild cognitive impairment (MCI) or early dementia. We successfully undertook a feasibility randomised controlled trial (RCT) to refine the intervention and research delivery. We are now delivering a multi-centred RCT to evaluate its clinical and cost-effectiveness.

METHODS: We will recruit 368 people with MCI or early dementia (Montreal Cognitive Assessment score 13-25) and a family member or carer from memory assessment clinics, other community health or social care venues or an online register (the National Institute for Health Research Join Dementia Research). Participants will be randomised to an individually tailored activity and exercise programme delivered using motivational theory to promote adherence and continued engagement, with up to 50 supervised sessions over one year, or a brief falls prevention assessment (control). The intervention will be delivered in participants' homes by trained physiotherapists, occupational therapists and therapy assistants. We will measure disabilities in activities of daily living, physical activity, balance, cognition, mood, quality of life, falls, carer strain and healthcare and social care use. We will use a mixed methods approach to conduct a process evaluation to assess staff training and delivery of the intervention, and to identify individual- and context-level mechanisms affecting intervention engagement and activity maintenance. We will undertake a health economic evaluation to determine if the intervention is cost-effective.

DISCUSSION: We describe the protocol for a multi-centre RCT that will evaluate the clinical and cost-effectiveness of a therapy programme designed to promote activity and independence amongst people living with dementia.

TRIAL REGISTRATION: ISRCTN, ISRCTN15320670. Registered on 4 September 2018.

Iaith wreiddiol	Saesneg
Rhif yr erthygl	815
Nifer y tudalennau	11
Cyfnodolyn	Trials
Cyfrol	20
Rhif cyhoeddi	1
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1186/s13063-019-3871-9
Statws	Cyhoeddwyd - 30 Rhag 2019

Mynediad at Ddogfen

10.1186/s13063-019-3871-9Trwydded: CC BY

2019 TrialsFersiwn derfynol wedi’i chyhoeddi, 1.22 MBTrwydded: CC BY

Ôl bys

Gweld gwybodaeth am bynciau ymchwil 'A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) – A Protocol'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

Dyfynnu hyn

Bajwa, R., Goldberg, S., van der Wardt, V., Burgon, C., di Lorito, C., Godfrey, M., Dunlop, M. R., Logan, P., Masud, T., Gladman, J., Smith, H., Hood-Moore, V., Booth, V., das Nair, R., Pollock, K., Vedhara, K., Edwards, R. T., Jones, C., Hoare, Z., ... Harwood, R. (2019). A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) – A Protocol. Trials, 20(1), erthygl 815. https://doi.org/10.1186/s13063-019-3871-9

@article{2a86bb36d1cc491fb857b04c14d2e65e,

title = "A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) – A Protocol",

abstract = "BACKGROUND: People with dementia progressively lose cognitive and functional abilities. Interventions promoting exercise and activity may slow decline. We developed a novel intervention to promote activity and independence and prevent falls in people with mild cognitive impairment (MCI) or early dementia. We successfully undertook a feasibility randomised controlled trial (RCT) to refine the intervention and research delivery. We are now delivering a multi-centred RCT to evaluate its clinical and cost-effectiveness.METHODS: We will recruit 368 people with MCI or early dementia (Montreal Cognitive Assessment score 13-25) and a family member or carer from memory assessment clinics, other community health or social care venues or an online register (the National Institute for Health Research Join Dementia Research). Participants will be randomised to an individually tailored activity and exercise programme delivered using motivational theory to promote adherence and continued engagement, with up to 50 supervised sessions over one year, or a brief falls prevention assessment (control). The intervention will be delivered in participants' homes by trained physiotherapists, occupational therapists and therapy assistants. We will measure disabilities in activities of daily living, physical activity, balance, cognition, mood, quality of life, falls, carer strain and healthcare and social care use. We will use a mixed methods approach to conduct a process evaluation to assess staff training and delivery of the intervention, and to identify individual- and context-level mechanisms affecting intervention engagement and activity maintenance. We will undertake a health economic evaluation to determine if the intervention is cost-effective.DISCUSSION: We describe the protocol for a multi-centre RCT that will evaluate the clinical and cost-effectiveness of a therapy programme designed to promote activity and independence amongst people living with dementia.TRIAL REGISTRATION: ISRCTN, ISRCTN15320670. Registered on 4 September 2018.",

author = "R Bajwa and S. Goldberg and \{van der Wardt\}, Veronika and C Burgon and \{di Lorito\}, C and Maureen Godfrey and Dunlop, \{M. R.\} and Pip Logan and Tahir Masud and John Gladman and Helen Smith and Vicky Hood-Moore and Vicky Booth and \{das Nair\}, Roshan and K. Pollock and Kavita Vedhara and Edwards, \{Rhiannon Tudor\} and Carys Jones and Zoe Hoare and Andrew Brand and Rowan Harwood",

year = "2019",

month = dec,

day = "30",

doi = "10.1186/s13063-019-3871-9",

language = "English",

volume = "20",

journal = "Trials",

issn = "1745-6215",

publisher = "BioMed Central",

number = "1",

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Bajwa, R, Goldberg, S, van der Wardt, V, Burgon, C, di Lorito, C, Godfrey, M, Dunlop, MR, Logan, P, Masud, T, Gladman, J, Smith, H, Hood-Moore, V, Booth, V, das Nair, R, Pollock, K, Vedhara, K, Edwards, RT , Jones, C , Hoare, Z , Brand, A & Harwood, R 2019, 'A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) – A Protocol', Trials, cyfrol. 20, rhif 1, 815. https://doi.org/10.1186/s13063-019-3871-9

A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) – A Protocol. / Bajwa, R; Goldberg, S.; van der Wardt, Veronika et al.
Yn: Trials, Cyfrol 20, Rhif 1, 815, 30.12.2019.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

TY - JOUR

T1 - A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) – A Protocol

AU - Bajwa, R

AU - Goldberg, S.

AU - van der Wardt, Veronika

AU - Burgon, C

AU - di Lorito, C

AU - Godfrey, Maureen

AU - Dunlop, M. R.

AU - Logan, Pip

AU - Masud, Tahir

AU - Gladman, John

AU - Smith, Helen

AU - Hood-Moore, Vicky

AU - Booth, Vicky

AU - das Nair, Roshan

AU - Pollock, K.

AU - Vedhara, Kavita

AU - Edwards, Rhiannon Tudor

AU - Jones, Carys

AU - Hoare, Zoe

AU - Brand, Andrew

AU - Harwood, Rowan

PY - 2019/12/30

Y1 - 2019/12/30

N2 - BACKGROUND: People with dementia progressively lose cognitive and functional abilities. Interventions promoting exercise and activity may slow decline. We developed a novel intervention to promote activity and independence and prevent falls in people with mild cognitive impairment (MCI) or early dementia. We successfully undertook a feasibility randomised controlled trial (RCT) to refine the intervention and research delivery. We are now delivering a multi-centred RCT to evaluate its clinical and cost-effectiveness.METHODS: We will recruit 368 people with MCI or early dementia (Montreal Cognitive Assessment score 13-25) and a family member or carer from memory assessment clinics, other community health or social care venues or an online register (the National Institute for Health Research Join Dementia Research). Participants will be randomised to an individually tailored activity and exercise programme delivered using motivational theory to promote adherence and continued engagement, with up to 50 supervised sessions over one year, or a brief falls prevention assessment (control). The intervention will be delivered in participants' homes by trained physiotherapists, occupational therapists and therapy assistants. We will measure disabilities in activities of daily living, physical activity, balance, cognition, mood, quality of life, falls, carer strain and healthcare and social care use. We will use a mixed methods approach to conduct a process evaluation to assess staff training and delivery of the intervention, and to identify individual- and context-level mechanisms affecting intervention engagement and activity maintenance. We will undertake a health economic evaluation to determine if the intervention is cost-effective.DISCUSSION: We describe the protocol for a multi-centre RCT that will evaluate the clinical and cost-effectiveness of a therapy programme designed to promote activity and independence amongst people living with dementia.TRIAL REGISTRATION: ISRCTN, ISRCTN15320670. Registered on 4 September 2018.

AB - BACKGROUND: People with dementia progressively lose cognitive and functional abilities. Interventions promoting exercise and activity may slow decline. We developed a novel intervention to promote activity and independence and prevent falls in people with mild cognitive impairment (MCI) or early dementia. We successfully undertook a feasibility randomised controlled trial (RCT) to refine the intervention and research delivery. We are now delivering a multi-centred RCT to evaluate its clinical and cost-effectiveness.METHODS: We will recruit 368 people with MCI or early dementia (Montreal Cognitive Assessment score 13-25) and a family member or carer from memory assessment clinics, other community health or social care venues or an online register (the National Institute for Health Research Join Dementia Research). Participants will be randomised to an individually tailored activity and exercise programme delivered using motivational theory to promote adherence and continued engagement, with up to 50 supervised sessions over one year, or a brief falls prevention assessment (control). The intervention will be delivered in participants' homes by trained physiotherapists, occupational therapists and therapy assistants. We will measure disabilities in activities of daily living, physical activity, balance, cognition, mood, quality of life, falls, carer strain and healthcare and social care use. We will use a mixed methods approach to conduct a process evaluation to assess staff training and delivery of the intervention, and to identify individual- and context-level mechanisms affecting intervention engagement and activity maintenance. We will undertake a health economic evaluation to determine if the intervention is cost-effective.DISCUSSION: We describe the protocol for a multi-centre RCT that will evaluate the clinical and cost-effectiveness of a therapy programme designed to promote activity and independence amongst people living with dementia.TRIAL REGISTRATION: ISRCTN, ISRCTN15320670. Registered on 4 September 2018.

U2 - 10.1186/s13063-019-3871-9

DO - 10.1186/s13063-019-3871-9

M3 - Article

C2 - 31888709

SN - 1745-6215

VL - 20

JO - Trials

JF - Trials

IS - 1

M1 - 815

ER -