BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation

Cristiano Palego

doi:10.1109/MWSYM.2016.7540266

BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation

Cristiano Palego

Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Cyfraniad i Gynhadledd › adolygiad gan gymheiriaid

272 Wedi eu Llwytho i Lawr (Pure)

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A novel microfluidic biosensing platform based on Bipolar-Complementary Oxide Semiconductor (BiCMOS) technology is presented. The device relies on a quadruple electrode system and a microfluidic channel that are directly integrated into the back-end-of-line (BEOL) of the BiCMOS stack. For proof of concept repeatable electrical trapping of single SW620 (colon cancer) cells in the quadruple electrode system is initially demonstrated. Additionally, for the first time a microwave intermodulation technique is used for high sensitivity dielectric spectroscopy, which could pave the way to label-free monitoring of intracellular processes and manipulation such as electroporation.

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Teitl	Microwave Symposium (IMS), 2016 IEEE MTT-S International
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1109/MWSYM.2016.7540266
Statws	Cyhoeddwyd - 11 Awst 2016

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10.1109/MWSYM.2016.7540266

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@inproceedings{9b9e68a29cca412e876290774181e863,

title = "BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation",

abstract = "A novel microfluidic biosensing platform based on Bipolar-Complementary Oxide Semiconductor (BiCMOS) technology is presented. The device relies on a quadruple electrode system and a microfluidic channel that are directly integrated into the back-end-of-line (BEOL) of the BiCMOS stack. For proof of concept repeatable electrical trapping of single SW620 (colon cancer) cells in the quadruple electrode system is initially demonstrated. Additionally, for the first time a microwave intermodulation technique is used for high sensitivity dielectric spectroscopy, which could pave the way to label-free monitoring of intracellular processes and manipulation such as electroporation.",

keywords = "Microfluidics, Microwave theory and techniques, Charge carrier processes, BiCMOS integrated circuits, Electrodes, Monitoring, Radio frequency",

author = "Cristiano Palego",

year = "2016",

month = aug,

day = "11",

doi = "10.1109/MWSYM.2016.7540266",

language = "English",

booktitle = "Microwave Symposium (IMS), 2016 IEEE MTT-S International",

}

TY - GEN

T1 - BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation

AU - Palego, Cristiano

PY - 2016/8/11

Y1 - 2016/8/11

N2 - A novel microfluidic biosensing platform based on Bipolar-Complementary Oxide Semiconductor (BiCMOS) technology is presented. The device relies on a quadruple electrode system and a microfluidic channel that are directly integrated into the back-end-of-line (BEOL) of the BiCMOS stack. For proof of concept repeatable electrical trapping of single SW620 (colon cancer) cells in the quadruple electrode system is initially demonstrated. Additionally, for the first time a microwave intermodulation technique is used for high sensitivity dielectric spectroscopy, which could pave the way to label-free monitoring of intracellular processes and manipulation such as electroporation.

AB - A novel microfluidic biosensing platform based on Bipolar-Complementary Oxide Semiconductor (BiCMOS) technology is presented. The device relies on a quadruple electrode system and a microfluidic channel that are directly integrated into the back-end-of-line (BEOL) of the BiCMOS stack. For proof of concept repeatable electrical trapping of single SW620 (colon cancer) cells in the quadruple electrode system is initially demonstrated. Additionally, for the first time a microwave intermodulation technique is used for high sensitivity dielectric spectroscopy, which could pave the way to label-free monitoring of intracellular processes and manipulation such as electroporation.

KW - Microfluidics, Microwave theory and techniques, Charge carrier processes, BiCMOS integrated circuits, Electrodes, Monitoring, Radio frequency

U2 - 10.1109/MWSYM.2016.7540266

DO - 10.1109/MWSYM.2016.7540266

M3 - Conference contribution

BT - Microwave Symposium (IMS), 2016 IEEE MTT-S International

ER -

BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation

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