Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

Lin Zhou; Chen Liu; Zhengbo Sun; Hongju Mao; Lin Zhang; Xuefeng Yu; Jianlong Zhao; Xianfeng Chen

doi:10.1016/j.bios.2019.04.044

Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

Lin Zhou
, Chen Liu
, Zhengbo Sun
, Hongju Mao
, Lin Zhang
, Xuefeng Yu
, Jianlong Zhao
, Xianfeng Chen

Ysgol Cyfrifiadureg a Pheirianneg

Chinese Academy of Sciences, Shanghai
Chinese Academy of Sciences, Shenzhen
Aston University

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

144 Wedi eu Llwytho i Lawr (Pure)

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We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating
ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	140-147
Nifer y tudalennau	8
Cyfnodolyn	Biosensors and Bioelectronics
Cyfrol	137
Dyddiad ar-lein cynnar	25 Ebr 2019
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.bios.2019.04.044
Statws	Cyhoeddwyd - 15 Gorff 2019

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10.1016/j.bios.2019.04.044

2019-Black phosphorus based fiber opticLlawysgrif awdur wedi’i dderbyn, 1.17 MBTrwydded: CC BY-NC-ND

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@article{22a4ee73c8984564ba925072b90fb695,

title = "Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis",

abstract = "We propose the first black phosphorus (BP) {\textendash} fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.",

author = "Lin Zhou and Chen Liu and Zhengbo Sun and Hongju Mao and Lin Zhang and Xuefeng Yu and Jianlong Zhao and Xianfeng Chen",

note = "Supplementary data related to this article can be found at https://doi.org/10.1016/j.bios.2019.04.044. The authors acknowledge support from the projects of EU FP7 PIRSES-GA-2013-612267 (iPhoto Bio, European Commission); the S{\^e}r Cymru NRN Fund (NRN097, United Kingdom); the National Natural Science Foundation of China (No. 61571429 and 61801464, China).",

year = "2019",

month = jul,

day = "15",

doi = "10.1016/j.bios.2019.04.044",

language = "English",

volume = "137",

pages = "140--147",

journal = "Biosensors and Bioelectronics",

issn = "0956-5663",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

AU - Zhou, Lin

AU - Liu, Chen

AU - Sun, Zhengbo

AU - Mao, Hongju

AU - Zhang, Lin

AU - Yu, Xuefeng

AU - Zhao, Jianlong

AU - Chen, Xianfeng

N1 - Supplementary data related to this article can be found at https://doi.org/10.1016/j.bios.2019.04.044. The authors acknowledge support from the projects of EU FP7 PIRSES-GA-2013-612267 (iPhoto Bio, European Commission); the Sêr Cymru NRN Fund (NRN097, United Kingdom); the National Natural Science Foundation of China (No. 61571429 and 61801464, China).

PY - 2019/7/15

Y1 - 2019/7/15

N2 - We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.

AB - We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.

U2 - 10.1016/j.bios.2019.04.044

DO - 10.1016/j.bios.2019.04.044

M3 - Article

SN - 0956-5663

VL - 137

SP - 140

EP - 147

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

ER -

Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

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