Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial

Juliet Briggs; Elizabeth Ralston; Thomas J Wilkinson; Christy Walklin; Emmanuel Mangahis; Hannah M L Young; Ellen M Castle; Roseanne E Billany; Elham Asgari; Sunil Bhandari; Kate Bramham; James O Burton; Jackie Campbell; Joseph Chilcot; Vashist Deelchand; Alexander Hamilton; Mark Jesky; Philip A Kalra; Kieran McCafferty; Andrew C Nixon; Zoe L Saynor; Maarten W Taal; James Tollitt; David C Wheeler; Jamie Macdonald; Sharlene A Greenwood

doi:10.1093/ckj/sfaf041

Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial

Juliet Briggs
, Elizabeth Ralston
, Thomas J Wilkinson
, Christy Walklin
, Emmanuel Mangahis
, Hannah M L Young
, Ellen M Castle
, Roseanne E Billany
, Elham Asgari
, Sunil Bhandari
, Kate Bramham
, James O Burton
, Jackie Campbell
, Joseph Chilcot
, Vashist Deelchand
, Alexander Hamilton
, Mark Jesky
, Philip A Kalra
, Kieran McCafferty
, Andrew C Nixon

Zoe L Saynor, Maarten W Taal, James Tollitt, David C Wheeler, Jamie Macdonald, Sharlene A Greenwood

Ysgol Seicoleg a Gwyddor Chwaraeon

Motor Nerve Clinic, Academic Neurosciences Centre, King’s College Hospital NHS Foundation Trust
King's College London
National Institute of Health Research Leicester Biomedical Research Centre
University Hospitals of Leicester NHS Trust
Curtin University
University of Leicester
Guys and St Thomas's Hospital
Hull University Teaching Hospitals NHS
University of Northampton
Department of Nephrology Royal Free Hospital
Department of Nephrology Royal Hospital
Department of Nephrology Salford Royal Hospital
Lancashire Teaching Hospitals NHS Foundation Trust
University of Southampton
University of Nottingham
University College London

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

24 Wedi eu Llwytho i Lawr (Pure)

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Background
In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD.

Methods
This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews.

Results
All 60 individuals (mean 53 years, 37% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95% confidence interval 1.0–7.4) arbitrary units, P = .012]. Significant between-group differences in KDQoL subscales—burden of kidney disease (P = .034), emotional wellbeing (P = .001) and energy/fatigue (P = .001)—were also achieved. There was no significant between-group difference in KDQoL PCS scores (P = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (P = .010) and body mass (P = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management.

Conclusion
A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour.

Iaith wreiddiol	Saesneg
Rhif yr erthygl	sfaf041
Cyfnodolyn	Clinical Kidney Journal
Cyfrol	18
Rhif cyhoeddi	3
Dyddiad ar-lein cynnar	12 Chwef 2025
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1093/ckj/sfaf041
Statws	Cyhoeddwyd - 10 Maw 2025

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10.1093/ckj/sfaf041Trwydded: CC BY

sfaf041Fersiwn derfynol wedi’i chyhoeddi, 1.14 MBTrwydded: CC BY

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Briggs, J., Ralston, E., Wilkinson, T. J., Walklin, C., Mangahis, E., Young, H. M. L., Castle, E. M., Billany, R. E., Asgari, E., Bhandari, S., Bramham, K., Burton, J. O., Campbell, J., Chilcot, J., Deelchand, V., Hamilton, A., Jesky, M., Kalra, P. A., McCafferty, K., ... Greenwood, S. A. (2025). Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial. Clinical Kidney Journal, 18(3), erthygl sfaf041. https://doi.org/10.1093/ckj/sfaf041

@article{1b7fffd06eb546d7974f3c42a9c664d5,

title = "Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial",

abstract = "Background In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD. Methods This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews. Results All 60 individuals (mean 53 years, 37\% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95\% confidence interval 1.0–7.4) arbitrary units, P = .012]. Significant between-group differences in KDQoL subscales—burden of kidney disease (P = .034), emotional wellbeing (P = .001) and energy/fatigue (P = .001)—were also achieved. There was no significant between-group difference in KDQoL PCS scores (P = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (P = .010) and body mass (P = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management. Conclusion A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour.",

author = "Juliet Briggs and Elizabeth Ralston and Wilkinson, \{Thomas J\} and Christy Walklin and Emmanuel Mangahis and Young, \{Hannah M L\} and Castle, \{Ellen M\} and Billany, \{Roseanne E\} and Elham Asgari and Sunil Bhandari and Kate Bramham and Burton, \{James O\} and Jackie Campbell and Joseph Chilcot and Vashist Deelchand and Alexander Hamilton and Mark Jesky and Kalra, \{Philip A\} and Kieran McCafferty and Nixon, \{Andrew C\} and Saynor, \{Zoe L\} and Taal, \{Maarten W\} and James Tollitt and Wheeler, \{David C\} and Jamie Macdonald and Greenwood, \{Sharlene A\}",

note = "{\textcopyright} The Author(s) 2025. Published by Oxford University Press on behalf of the ERA.",

year = "2025",

month = mar,

day = "10",

doi = "10.1093/ckj/sfaf041",

language = "English",

volume = "18",

journal = "Clinical Kidney Journal",

issn = "2048-8513",

publisher = "Oxford University Press",

number = "3",

}

Briggs, J, Ralston, E, Wilkinson, TJ, Walklin, C, Mangahis, E, Young, HML, Castle, EM, Billany, RE, Asgari, E, Bhandari, S, Bramham, K, Burton, JO, Campbell, J, Chilcot, J, Deelchand, V, Hamilton, A, Jesky, M, Kalra, PA, McCafferty, K, Nixon, AC, Saynor, ZL, Taal, MW, Tollitt, J, Wheeler, DC, Macdonald, J & Greenwood, SA 2025, 'Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial', Clinical Kidney Journal, cyfrol. 18, rhif 3, sfaf041. https://doi.org/10.1093/ckj/sfaf041

TY - JOUR

T1 - Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial

AU - Briggs, Juliet

AU - Ralston, Elizabeth

AU - Wilkinson, Thomas J

AU - Walklin, Christy

AU - Mangahis, Emmanuel

AU - Young, Hannah M L

AU - Castle, Ellen M

AU - Billany, Roseanne E

AU - Asgari, Elham

AU - Bhandari, Sunil

AU - Bramham, Kate

AU - Burton, James O

AU - Campbell, Jackie

AU - Chilcot, Joseph

AU - Deelchand, Vashist

AU - Hamilton, Alexander

AU - Jesky, Mark

AU - Kalra, Philip A

AU - McCafferty, Kieran

AU - Nixon, Andrew C

AU - Saynor, Zoe L

AU - Taal, Maarten W

AU - Tollitt, James

AU - Wheeler, David C

AU - Macdonald, Jamie

AU - Greenwood, Sharlene A

PY - 2025/3/10

Y1 - 2025/3/10

N2 - Background In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD. Methods This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews. Results All 60 individuals (mean 53 years, 37% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95% confidence interval 1.0–7.4) arbitrary units, P = .012]. Significant between-group differences in KDQoL subscales—burden of kidney disease (P = .034), emotional wellbeing (P = .001) and energy/fatigue (P = .001)—were also achieved. There was no significant between-group difference in KDQoL PCS scores (P = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (P = .010) and body mass (P = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management. Conclusion A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour.

AB - Background In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD. Methods This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews. Results All 60 individuals (mean 53 years, 37% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95% confidence interval 1.0–7.4) arbitrary units, P = .012]. Significant between-group differences in KDQoL subscales—burden of kidney disease (P = .034), emotional wellbeing (P = .001) and energy/fatigue (P = .001)—were also achieved. There was no significant between-group difference in KDQoL PCS scores (P = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (P = .010) and body mass (P = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management. Conclusion A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour.

U2 - 10.1093/ckj/sfaf041

DO - 10.1093/ckj/sfaf041

M3 - Article

C2 - 40065847

SN - 2048-8513

VL - 18

JO - Clinical Kidney Journal

JF - Clinical Kidney Journal

IS - 3

M1 - sfaf041

ER -

Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial

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