Engineering biology applications for environmental solutions: potential and challenges

David J. Lea-Smith; Francis Hassard; Frederic Coulon; Natalie Partridge; Louise Horsfall; Kyle D. J. Parker; Robert D. J. Smith; Ronan R. McCarty; Boyd McKew; Tony Guttierrez; Vinod Kumar; Gabriella Dotro; Zhugen Yang; Peter Golyshin; Natalio Krasnogor

doi:10.1038/s41467-025-58492-0

Engineering biology applications for environmental solutions: potential and challenges

David J. Lea-Smith
, Francis Hassard
, Frederic Coulon
, Natalie Partridge
, Louise Horsfall
, Kyle D. J. Parker
, Robert D. J. Smith
, Ronan R. McCarty
, Boyd McKew
, Tony Guttierrez
, Vinod Kumar
, Gabriella Dotro
, Zhugen Yang
, Peter Golyshin
, Natalio Krasnogor

Ysgol Gwyddorau Amgylcheddol a Naturiol

University of East Anglia
Cranfield University, Cranfield, UK
GitLife Biotech Ltd, Newcastle Upon Tyne, UK
University of Edinburgh
Brunel University
University of Essex
Heriot-Watt University, Edinburgh
EBIC Partners

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

43 Wedi eu Llwytho i Lawr (Pure)

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Engineering biology applies synthetic biology to address global environmental challenges like bioremediation, biosequestration, pollutant monitoring, and resource recovery. This perspective outlines innovations in engineering biology, its integration with other technologies (e.g., nanotechnology, IoT, AI), and commercial ventures leveraging these advancements. We also discuss commercialisation and scaling challenges, biosafety and biosecurity considerations including biocontainment strategies, social and political dimensions, and governance issues that must be addressed for successful real-world implementation. Finally, we highlight future perspectives and propose strategies to overcome existing hurdles, aiming to accelerate the adoption of engineering biology for environmental solutions.

Iaith wreiddiol	Saesneg
Rhif yr erthygl	3538
Cyfnodolyn	Nature Communications
Cyfrol	16
Dyddiad ar-lein cynnar	14 Ebr 2025
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1038/s41467-025-58492-0
Statws	E-gyhoeddi cyn argraffu - 14 Ebr 2025

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10.1038/s41467-025-58492-0Trwydded: CC BY

s41467-025-58492-0Fersiwn derfynol wedi’i chyhoeddi, 2.44 MBTrwydded: CC BY

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Lea-Smith, D. J., Hassard, F., Coulon, F., Partridge, N., Horsfall, L., Parker, K. D. J., Smith, R. D. J., McCarty, R. R., McKew, B., Guttierrez, T., Kumar, V., Dotro, G., Yang, Z., Golyshin, P., & Krasnogor, N. (2025). Engineering biology applications for environmental solutions: potential and challenges. Nature Communications, 16, erthygl 3538. Cyhoeddiad ar-lein ymlaen llaw. https://doi.org/10.1038/s41467-025-58492-0

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AU - Parker, Kyle D. J.

AU - Smith, Robert D. J.

AU - McCarty, Ronan R.

AU - McKew, Boyd

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AB - Engineering biology applies synthetic biology to address global environmental challenges like bioremediation, biosequestration, pollutant monitoring, and resource recovery. This perspective outlines innovations in engineering biology, its integration with other technologies (e.g., nanotechnology, IoT, AI), and commercial ventures leveraging these advancements. We also discuss commercialisation and scaling challenges, biosafety and biosecurity considerations including biocontainment strategies, social and political dimensions, and governance issues that must be addressed for successful real-world implementation. Finally, we highlight future perspectives and propose strategies to overcome existing hurdles, aiming to accelerate the adoption of engineering biology for environmental solutions.

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KW - Humans

KW - Nanotechnology

KW - Synthetic Biology/methods

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Engineering biology applications for environmental solutions: potential and challenges

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