Kidney Beam-A Cost-Effective Digital Intervention to Improve Mental Health

Sharlene A Greenwood; Juliet Briggs; Christy Walklin; Emmanuel Mangahis; Hannah M L Young; Ellen M Castle; Roseanne E Billany; Elham Asgari; Sunil Bhandari; Nicolette Bishop; Kate Bramham; James O Burton; Jackie Campbell; Joseph Chilcot; Nicola Cooper; Vashist Deelchand; Matthew P M Graham-Brown; Lynda Haggis; Alexander Hamilton; Mark Jesky; Philip A Kalra; Pelagia Koufaki; Kieran McCafferty; Andrew C Nixon; Helen Noble; Zoe L Saynor; Maarten W Taal; James Tollitt; David C Wheeler; Thomas J Wilkinson; Hannah Worboys; Jamie Macdonald

doi:10.1016/j.ekir.2024.08.030

Kidney Beam-A Cost-Effective Digital Intervention to Improve Mental Health

Sharlene A Greenwood
, Juliet Briggs
, Christy Walklin
, Emmanuel Mangahis
, Hannah M L Young
, Ellen M Castle
, Roseanne E Billany
, Elham Asgari
, Sunil Bhandari
, Nicolette Bishop
, Kate Bramham
, James O Burton
, Jackie Campbell
, Joseph Chilcot
, Nicola Cooper
, Vashist Deelchand
, Matthew P M Graham-Brown
, Lynda Haggis
, Alexander Hamilton
, Mark Jesky

Philip A Kalra, Pelagia Koufaki, Kieran McCafferty, Andrew C Nixon, Helen Noble, Zoe L Saynor, Maarten W Taal, James Tollitt, David C Wheeler, Thomas J Wilkinson, Hannah Worboys, Jamie Macdonald

Motor Nerve Clinic, Academic Neurosciences Centre, King’s College Hospital NHS Foundation Trust
University Hospitals of Leicester NHS Trust
Brunel University
University of Leicester
Guys and St Thomas's Hospital
Hull University Teaching Hospitals NHS
Loughborough University
King's College London
University of Northampton
Department of Nephrology Royal Free Hospital
Dept of Nephrology
Department of Nephrology Instituto Nacional de Cardiologia Ignacio Chávez
Department of Nephrology Royal Hospital
Queen Margaret University
Lancashire Teaching Hospitals NHS Foundation Trust
Queen's University, Belfast
University of Southampton
University of Nottingham
University College London
National Institute of Health Research Leicester Biomedical Research Centre

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

18 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Introduction
There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD.
Methods
In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention.
Results
At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained.
Conclusion
The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933).
Keywords: chronic kidney disease; cost-effectiveness; digital health intervention; physical activity; quality of life

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	3204-3217
Nifer y tudalennau	14
Cyfnodolyn	Kidney International Reports
Cyfrol	9
Rhif cyhoeddi	11
Dyddiad ar-lein cynnar	2 Medi 2024
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.ekir.2024.08.030
Statws	Cyhoeddwyd - 4 Tach 2024

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

NDC 3 Iechyd a Llesiant Da

Mynediad at Ddogfen

10.1016/j.ekir.2024.08.030Trwydded: CC BY

1-s2.0-S2468024924019156-mainFersiwn derfynol wedi’i chyhoeddi, 464 KBTrwydded: CC BY

Dyfynnu hyn

Greenwood, S. A., Briggs, J., Walklin, C., Mangahis, E., Young, H. M. L., Castle, E. M., Billany, R. E., Asgari, E., Bhandari, S., Bishop, N., Bramham, K., Burton, J. O., Campbell, J., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M. P. M., Haggis, L., Hamilton, A., ... Macdonald, J. (2024). Kidney Beam-A Cost-Effective Digital Intervention to Improve Mental Health. Kidney International Reports, 9(11), 3204-3217. https://doi.org/10.1016/j.ekir.2024.08.030

@article{4ff9ff9cf0634ee78f8c5ec0dbf5f4e3,

title = "Kidney Beam-A Cost-Effective Digital Intervention to Improve Mental Health",

abstract = "Introduction There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD. Methods In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention. Results At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95\% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93\% and 98\% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. Conclusion The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933). Keywords: chronic kidney disease; cost-effectiveness; digital health intervention; physical activity; quality of life ",

author = "Greenwood, \{Sharlene A\} and Juliet Briggs and Christy Walklin and Emmanuel Mangahis and Young, \{Hannah M L\} and Castle, \{Ellen M\} and Billany, \{Roseanne E\} and Elham Asgari and Sunil Bhandari and Nicolette Bishop and Kate Bramham and Burton, \{James O\} and Jackie Campbell and Joseph Chilcot and Nicola Cooper and Vashist Deelchand and Graham-Brown, \{Matthew P M\} and Lynda Haggis and Alexander Hamilton and Mark Jesky and Kalra, \{Philip A\} and Pelagia Koufaki and Kieran McCafferty and Nixon, \{Andrew C\} and Helen Noble and Saynor, \{Zoe L\} and Taal, \{Maarten W\} and James Tollitt and Wheeler, \{David C\} and Wilkinson, \{Thomas J\} and Hannah Worboys and Jamie Macdonald",

note = "Crown Copyright {\textcopyright} 2024 Published by Elsevier Inc. on behalf of the International Society of Nephrology.",

year = "2024",

month = nov,

day = "4",

doi = "10.1016/j.ekir.2024.08.030",

language = "English",

volume = "9",

pages = "3204--3217",

journal = "Kidney International Reports",

issn = "2468-0249",

publisher = "Elsevier Inc.",

number = "11",

}

Greenwood, SA, Briggs, J, Walklin, C, Mangahis, E, Young, HML, Castle, EM, Billany, RE, Asgari, E, Bhandari, S, Bishop, N, Bramham, K, Burton, JO, Campbell, J, Chilcot, J, Cooper, N, Deelchand, V, Graham-Brown, MPM, Haggis, L, Hamilton, A, Jesky, M, Kalra, PA, Koufaki, P, McCafferty, K, Nixon, AC, Noble, H, Saynor, ZL, Taal, MW, Tollitt, J, Wheeler, DC, Wilkinson, TJ, Worboys, H & Macdonald, J 2024, 'Kidney Beam-A Cost-Effective Digital Intervention to Improve Mental Health', Kidney International Reports, cyfrol. 9, rhif 11, tt. 3204-3217. https://doi.org/10.1016/j.ekir.2024.08.030

TY - JOUR

T1 - Kidney Beam-A Cost-Effective Digital Intervention to Improve Mental Health

AU - Greenwood, Sharlene A

AU - Briggs, Juliet

AU - Walklin, Christy

AU - Mangahis, Emmanuel

AU - Young, Hannah M L

AU - Castle, Ellen M

AU - Billany, Roseanne E

AU - Asgari, Elham

AU - Bhandari, Sunil

AU - Bishop, Nicolette

AU - Bramham, Kate

AU - Burton, James O

AU - Campbell, Jackie

AU - Chilcot, Joseph

AU - Cooper, Nicola

AU - Deelchand, Vashist

AU - Graham-Brown, Matthew P M

AU - Haggis, Lynda

AU - Hamilton, Alexander

AU - Jesky, Mark

AU - Kalra, Philip A

AU - Koufaki, Pelagia

AU - McCafferty, Kieran

AU - Nixon, Andrew C

AU - Noble, Helen

AU - Saynor, Zoe L

AU - Taal, Maarten W

AU - Tollitt, James

AU - Wheeler, David C

AU - Wilkinson, Thomas J

AU - Worboys, Hannah

AU - Macdonald, Jamie

PY - 2024/11/4

Y1 - 2024/11/4

N2 - Introduction There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD. Methods In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention. Results At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. Conclusion The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933). Keywords: chronic kidney disease; cost-effectiveness; digital health intervention; physical activity; quality of life

AB - Introduction There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD. Methods In a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention. Results At 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained. Conclusion The Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933). Keywords: chronic kidney disease; cost-effectiveness; digital health intervention; physical activity; quality of life

U2 - 10.1016/j.ekir.2024.08.030

DO - 10.1016/j.ekir.2024.08.030

M3 - Article

C2 - 39534205

SN - 2468-0249

VL - 9

SP - 3204

EP - 3217

JO - Kidney International Reports

JF - Kidney International Reports

IS - 11

ER -

Kidney Beam-A Cost-Effective Digital Intervention to Improve Mental Health

Crynodeb

NDC y CU

Mynediad at Ddogfen

Ôl bys

Dyfynnu hyn