Nanopore test circuit for single-strand DNA sequencing

C. Palego; J.C. Hwang; C. Merla; F. Apollonio; M. Liberti

doi:10.1109/SiRF.2012.6160154

Nanopore test circuit for single-strand DNA sequencing

C. Palego
, J.C. Hwang
, C. Merla
, F. Apollonio
, M. Liberti

Allbwn ymchwil: Cyfraniad at gynhadledd › Papur

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A nanopore test circuit is proposed for single-strand DNA sequencing, which allows real-time sensing of the electric conductance of individual sections of a DNA strand as it is pulled through the nanopore by an electric current at a controlled speed. The test circuit is based on a planar microchamber with a nanochannel drilled through its multilayer graphene electrode by an electron beam. The nanochannel is self-aligned with a nanopore created in the lipid bilayer membrane of liposomes by nanosecond electric pulses. Simulation shows that by carefully controlling the magnitude, period, and repetition rate of the pulses, the diameter of the nanopore can be optimized for the best speed the DNA is pulled through the nanopore.

Iaith wreiddiol	Saesneg
Tudalennau	101-104
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1109/SiRF.2012.6160154
Statws	Cyhoeddwyd - 16 Ion 2012
Digwyddiad	IEEE 12th Topical Meeting on Silicon Monolithic Integrated Circuits in RF Systems (SiRF), Santa Clara, USA, 16-18 Jan 2012 - Hyd: 3 Ion 0001 → …

Cynhadledd

Cynhadledd	IEEE 12th Topical Meeting on Silicon Monolithic Integrated Circuits in RF Systems (SiRF), Santa Clara, USA, 16-18 Jan 2012
Cyfnod	3/01/01 → …

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10.1109/SiRF.2012.6160154

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@conference{a992101500fb48588865e592c00eef1b,

title = "Nanopore test circuit for single-strand DNA sequencing",

abstract = "A nanopore test circuit is proposed for single-strand DNA sequencing, which allows real-time sensing of the electric conductance of individual sections of a DNA strand as it is pulled through the nanopore by an electric current at a controlled speed. The test circuit is based on a planar microchamber with a nanochannel drilled through its multilayer graphene electrode by an electron beam. The nanochannel is self-aligned with a nanopore created in the lipid bilayer membrane of liposomes by nanosecond electric pulses. Simulation shows that by carefully controlling the magnitude, period, and repetition rate of the pulses, the diameter of the nanopore can be optimized for the best speed the DNA is pulled through the nanopore.",

author = "C. Palego and J.C. Hwang and C. Merla and F. Apollonio and M. Liberti",

year = "2012",

month = jan,

day = "16",

doi = "10.1109/SiRF.2012.6160154",

language = "English",

pages = "101--104",

note = "IEEE 12th Topical Meeting on Silicon Monolithic Integrated Circuits in RF Systems (SiRF), Santa Clara, USA, 16-18 Jan 2012 ; Conference date: 03-01-0001",

}

TY - CONF

T1 - Nanopore test circuit for single-strand DNA sequencing

AU - Palego, C.

AU - Hwang, J.C.

AU - Merla, C.

AU - Apollonio, F.

AU - Liberti, M.

PY - 2012/1/16

Y1 - 2012/1/16

N2 - A nanopore test circuit is proposed for single-strand DNA sequencing, which allows real-time sensing of the electric conductance of individual sections of a DNA strand as it is pulled through the nanopore by an electric current at a controlled speed. The test circuit is based on a planar microchamber with a nanochannel drilled through its multilayer graphene electrode by an electron beam. The nanochannel is self-aligned with a nanopore created in the lipid bilayer membrane of liposomes by nanosecond electric pulses. Simulation shows that by carefully controlling the magnitude, period, and repetition rate of the pulses, the diameter of the nanopore can be optimized for the best speed the DNA is pulled through the nanopore.

AB - A nanopore test circuit is proposed for single-strand DNA sequencing, which allows real-time sensing of the electric conductance of individual sections of a DNA strand as it is pulled through the nanopore by an electric current at a controlled speed. The test circuit is based on a planar microchamber with a nanochannel drilled through its multilayer graphene electrode by an electron beam. The nanochannel is self-aligned with a nanopore created in the lipid bilayer membrane of liposomes by nanosecond electric pulses. Simulation shows that by carefully controlling the magnitude, period, and repetition rate of the pulses, the diameter of the nanopore can be optimized for the best speed the DNA is pulled through the nanopore.

U2 - 10.1109/SiRF.2012.6160154

DO - 10.1109/SiRF.2012.6160154

M3 - Paper

SP - 101

EP - 104

T2 - IEEE 12th Topical Meeting on Silicon Monolithic Integrated Circuits in RF Systems (SiRF), Santa Clara, USA, 16-18 Jan 2012

Y2 - 3 January 0001

ER -

Nanopore test circuit for single-strand DNA sequencing

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