On the ancestral recruitment of metalloproteinases into the venom of snakes

N.R. Casewell

doi:10.1016/j.toxicon.2012.02.006

On the ancestral recruitment of metalloproteinases into the venom of snakes

N.R. Casewell

Prifysgol Bangor

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

Crynodeb

Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	449-454
Cyfnodolyn	Toxicon
Cyfrol	60
Rhif cyhoeddi	4
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.toxicon.2012.02.006
Statws	Cyhoeddwyd - 15 Medi 2012

Mynediad at Ddogfen

10.1016/j.toxicon.2012.02.006

Dyfynnu hyn

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title = "On the ancestral recruitment of metalloproteinases into the venom of snakes",

abstract = "Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.",

author = "N.R. Casewell",

year = "2012",

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AB - Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.

U2 - 10.1016/j.toxicon.2012.02.006

DO - 10.1016/j.toxicon.2012.02.006

M3 - Article

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VL - 60

SP - 449

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JO - Toxicon

JF - Toxicon

IS - 4

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On the ancestral recruitment of metalloproteinases into the venom of snakes

Crynodeb

Mynediad at Ddogfen

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Dyfynnu hyn