Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway

P.J. Murphy; D.M. Evans; P.N. Horton; M.B. Hursthouse

doi:10.1039/C4RA03031A

Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway

P.J. Murphy
, D.M. Evans
, P.N. Horton
, M.B. Hursthouse

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

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Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	20744-20751
Cyfnodolyn	RSC Advances
Cyfrol	4
Rhif cyhoeddi	40
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1039/C4RA03031A
Statws	Cyhoeddwyd - 28 Ebr 2014

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10.1039/C4RA03031A

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@article{0a80f879b429435ca49d38e8fe91d462,

title = "Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway",

abstract = "Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24.",

author = "P.J. Murphy and D.M. Evans and P.N. Horton and M.B. Hursthouse",

year = "2014",

month = apr,

day = "28",

doi = "10.1039/C4RA03031A",

language = "English",

volume = "4",

pages = "20744--20751",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "40",

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T1 - Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway

AU - Murphy, P.J.

AU - Evans, D.M.

AU - Horton, P.N.

AU - Hursthouse, M.B.

PY - 2014/4/28

Y1 - 2014/4/28

N2 - Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24.

AB - Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24.

U2 - 10.1039/C4RA03031A

DO - 10.1039/C4RA03031A

M3 - Article

SN - 2046-2069

VL - 4

SP - 20744

EP - 20751

JO - RSC Advances

JF - RSC Advances

IS - 40

ER -

Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway

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