The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM)

C. G. Walklin; Hannah M.L Young; E. Asghari; S. Bhandari; R. E. Billany; N. Bishop; K. Bramham; J. Briggs; J. O. Burton; J. Campbell; E. M. Castle; J. Chilcot; N. Cooper; V. Deelchand; M. P.M Graham-Brown; A. Hamilton; M. Jesky; P. A. Kalra; P. Koufaki; K. McCafferty; A. C. Nixon; H. Noble; Z. L. Saynor; C. Sothinathan; M. W. Taal; J. Tollitt; D.C Wheeler; T. J. Wilkinson; J.H Macdonald; S. A. Greenwood

doi:10.1186/s12882-023-03173-7

The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM)

C. G. Walklin
, Hannah M.L Young
, E. Asghari
, S. Bhandari
, R. E. Billany
, N. Bishop
, K. Bramham
, J. Briggs
, J. O. Burton
, J. Campbell
, E. M. Castle
, J. Chilcot
, N. Cooper
, V. Deelchand
, M. P.M Graham-Brown
, A. Hamilton
, M. Jesky
, P. A. Kalra
, P. Koufaki
, K. McCafferty

A. C. Nixon, H. Noble, Z. L. Saynor, C. Sothinathan, M. W. Taal, J. Tollitt, D.C Wheeler, T. J. Wilkinson, J.H Macdonald, S. A. Greenwood

Motor Nerve Clinic, Academic Neurosciences Centre, King’s College Hospital NHS Foundation Trust
Leicester General Hospital
Guy’s and St Thomas’ NHS Trust
Hull University Teaching Hospitals NHS
King's College London

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

47 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Background
Physical activity and emotional self-management has the potential to enhance health-related quality of life (HRQoL), but few people with chronic kidney disease (CKD) have access to resources and support. The Kidney BEAM trial aims to evaluate whether an evidence-based physical activity and emotional wellbeing self-management programme (Kidney BEAM) leads to improvements in HRQoL in people with CKD.

Methods
This was a prospective, multicentre, randomised waitlist-controlled trial, with health economic analysis and nested qualitative studies. In total, three hundred and four adults with established CKD were recruited from 11 UK kidney units. Participants were randomly assigned to the intervention (Kidney BEAM) or a wait list control group (1:1). The primary outcome was the between-group difference in Kidney Disease Quality of Life (KDQoL) mental component summary score (MCS) at 12 weeks. Secondary outcomes included the KDQoL physical component summary score, kidney-specific scores, fatigue, life participation, depression and anxiety, physical function, clinical chemistry, healthcare utilisation and harms. All outcomes were measured at baseline and 12 weeks, with long-term HRQoL and adherence also collected at six months follow-up. A nested qualitative study explored experience and impact of using Kidney BEAM.

Results
340 participants were randomised to Kidney BEAM (n = 173) and waiting list (n = 167) groups. There were 96 (55%) and 89 (53%) males in the intervention and waiting list groups respectively, and the mean (SD) age was 53 (14) years in both groups. Ethnicity, body mass, CKD stage, and history of diabetes and hypertension were comparable across groups. The mean (SD) of the MCS was similar in both groups, 44.7 (10.8) and 45.9 (10.6) in the intervention and waiting list groups respectively.

Conclusion
Results from this trial will establish whether the Kidney BEAM self management programme is a cost-effective method of enhancing mental and physical wellbeing of people with CKD.

Iaith wreiddiol	Saesneg
Rhif yr erthygl	122
Nifer y tudalennau	17
Cyfnodolyn	BMC Nephrology
Cyfrol	24
Rhif cyhoeddi	1
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1186/s12882-023-03173-7
Statws	Cyhoeddwyd - 2 Mai 2023

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

NDC 3 Iechyd a Llesiant Da

Mynediad at Ddogfen

10.1186/s12882-023-03173-7Trwydded: CC BY

Walklin 2023Fersiwn derfynol wedi’i chyhoeddi, 1.7 MBTrwydded: CC BY

Ôl bys

Gweld gwybodaeth am bynciau ymchwil 'The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM)'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

Dyfynnu hyn

Walklin, C. G., Young, H. M. L., Asghari, E., Bhandari, S., Billany, R. E., Bishop, N., Bramham, K., Briggs, J., Burton, J. O., Campbell, J., Castle, E. M., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M. P. M., Hamilton, A., Jesky, M., Kalra, P. A., Koufaki, P., ... Greenwood, S. A. (2023). The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM). BMC Nephrology, 24(1), erthygl 122. https://doi.org/10.1186/s12882-023-03173-7

Walklin, C. G. ; Young, Hannah M.L ; Asghari, E. et al. / The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM). Yn: BMC Nephrology. 2023 ; Cyfrol 24, Rhif 1.

@article{ff62eebc45a240a191304e5cbd419f70,

title = "The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM)",

abstract = "Background Physical activity and emotional self-management has the potential to enhance health-related quality of life (HRQoL), but few people with chronic kidney disease (CKD) have access to resources and support. The Kidney BEAM trial aims to evaluate whether an evidence-based physical activity and emotional wellbeing self-management programme (Kidney BEAM) leads to improvements in HRQoL in people with CKD. Methods This was a prospective, multicentre, randomised waitlist-controlled trial, with health economic analysis and nested qualitative studies. In total, three hundred and four adults with established CKD were recruited from 11 UK kidney units. Participants were randomly assigned to the intervention (Kidney BEAM) or a wait list control group (1:1). The primary outcome was the between-group difference in Kidney Disease Quality of Life (KDQoL) mental component summary score (MCS) at 12 weeks. Secondary outcomes included the KDQoL physical component summary score, kidney-specific scores, fatigue, life participation, depression and anxiety, physical function, clinical chemistry, healthcare utilisation and harms. All outcomes were measured at baseline and 12 weeks, with long-term HRQoL and adherence also collected at six months follow-up. A nested qualitative study explored experience and impact of using Kidney BEAM. Results 340 participants were randomised to Kidney BEAM (n = 173) and waiting list (n = 167) groups. There were 96 (55\%) and 89 (53\%) males in the intervention and waiting list groups respectively, and the mean (SD) age was 53 (14) years in both groups. Ethnicity, body mass, CKD stage, and history of diabetes and hypertension were comparable across groups. The mean (SD) of the MCS was similar in both groups, 44.7 (10.8) and 45.9 (10.6) in the intervention and waiting list groups respectively. Conclusion Results from this trial will establish whether the Kidney BEAM self management programme is a cost-effective method of enhancing mental and physical wellbeing of people with CKD.",

keywords = "Adult, Exercise, Female, Humans, Male, Middle Aged, Prospective Studies, Quality of Life, Renal Insufficiency, Chronic/therapy, Telemedicine, Waiting Lists",

author = "Walklin, \{C. G.\} and Young, \{Hannah M.L\} and E. Asghari and S. Bhandari and Billany, \{R. E.\} and N. Bishop and K. Bramham and J. Briggs and Burton, \{J. O.\} and J. Campbell and Castle, \{E. M.\} and J. Chilcot and N. Cooper and V. Deelchand and Graham-Brown, \{M. P.M\} and A. Hamilton and M. Jesky and Kalra, \{P. A.\} and P. Koufaki and K. McCafferty and Nixon, \{A. C.\} and H. Noble and Saynor, \{Z. L.\} and C. Sothinathan and Taal, \{M. W.\} and J. Tollitt and D.C Wheeler and Wilkinson, \{T. J.\} and J.H Macdonald and Greenwood, \{S. A.\}",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

month = may,

day = "2",

doi = "10.1186/s12882-023-03173-7",

language = "English",

volume = "24",

journal = "BMC Nephrology",

issn = "1471-2369",

publisher = "BioMed Central",

number = "1",

}

Walklin, CG, Young, HML, Asghari, E, Bhandari, S, Billany, RE, Bishop, N, Bramham, K, Briggs, J, Burton, JO, Campbell, J, Castle, EM, Chilcot, J, Cooper, N, Deelchand, V, Graham-Brown, MPM, Hamilton, A, Jesky, M, Kalra, PA, Koufaki, P, McCafferty, K, Nixon, AC, Noble, H, Saynor, ZL, Sothinathan, C, Taal, MW, Tollitt, J, Wheeler, DC, Wilkinson, TJ, Macdonald, JH & Greenwood, SA 2023, 'The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM)', BMC Nephrology, cyfrol. 24, rhif 1, 122. https://doi.org/10.1186/s12882-023-03173-7

The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM). / Walklin, C. G.; Young, Hannah M.L; Asghari, E. et al.
Yn: BMC Nephrology, Cyfrol 24, Rhif 1, 122, 02.05.2023.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

TY - JOUR

T1 - The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM)

AU - Walklin, C. G.

AU - Young, Hannah M.L

AU - Asghari, E.

AU - Bhandari, S.

AU - Billany, R. E.

AU - Bishop, N.

AU - Bramham, K.

AU - Briggs, J.

AU - Burton, J. O.

AU - Campbell, J.

AU - Castle, E. M.

AU - Chilcot, J.

AU - Cooper, N.

AU - Deelchand, V.

AU - Graham-Brown, M. P.M

AU - Hamilton, A.

AU - Jesky, M.

AU - Kalra, P. A.

AU - Koufaki, P.

AU - McCafferty, K.

AU - Nixon, A. C.

AU - Noble, H.

AU - Saynor, Z. L.

AU - Sothinathan, C.

AU - Taal, M. W.

AU - Tollitt, J.

AU - Wheeler, D.C

AU - Wilkinson, T. J.

AU - Macdonald, J.H

AU - Greenwood, S. A.

PY - 2023/5/2

Y1 - 2023/5/2

N2 - Background Physical activity and emotional self-management has the potential to enhance health-related quality of life (HRQoL), but few people with chronic kidney disease (CKD) have access to resources and support. The Kidney BEAM trial aims to evaluate whether an evidence-based physical activity and emotional wellbeing self-management programme (Kidney BEAM) leads to improvements in HRQoL in people with CKD. Methods This was a prospective, multicentre, randomised waitlist-controlled trial, with health economic analysis and nested qualitative studies. In total, three hundred and four adults with established CKD were recruited from 11 UK kidney units. Participants were randomly assigned to the intervention (Kidney BEAM) or a wait list control group (1:1). The primary outcome was the between-group difference in Kidney Disease Quality of Life (KDQoL) mental component summary score (MCS) at 12 weeks. Secondary outcomes included the KDQoL physical component summary score, kidney-specific scores, fatigue, life participation, depression and anxiety, physical function, clinical chemistry, healthcare utilisation and harms. All outcomes were measured at baseline and 12 weeks, with long-term HRQoL and adherence also collected at six months follow-up. A nested qualitative study explored experience and impact of using Kidney BEAM. Results 340 participants were randomised to Kidney BEAM (n = 173) and waiting list (n = 167) groups. There were 96 (55%) and 89 (53%) males in the intervention and waiting list groups respectively, and the mean (SD) age was 53 (14) years in both groups. Ethnicity, body mass, CKD stage, and history of diabetes and hypertension were comparable across groups. The mean (SD) of the MCS was similar in both groups, 44.7 (10.8) and 45.9 (10.6) in the intervention and waiting list groups respectively. Conclusion Results from this trial will establish whether the Kidney BEAM self management programme is a cost-effective method of enhancing mental and physical wellbeing of people with CKD.

AB - Background Physical activity and emotional self-management has the potential to enhance health-related quality of life (HRQoL), but few people with chronic kidney disease (CKD) have access to resources and support. The Kidney BEAM trial aims to evaluate whether an evidence-based physical activity and emotional wellbeing self-management programme (Kidney BEAM) leads to improvements in HRQoL in people with CKD. Methods This was a prospective, multicentre, randomised waitlist-controlled trial, with health economic analysis and nested qualitative studies. In total, three hundred and four adults with established CKD were recruited from 11 UK kidney units. Participants were randomly assigned to the intervention (Kidney BEAM) or a wait list control group (1:1). The primary outcome was the between-group difference in Kidney Disease Quality of Life (KDQoL) mental component summary score (MCS) at 12 weeks. Secondary outcomes included the KDQoL physical component summary score, kidney-specific scores, fatigue, life participation, depression and anxiety, physical function, clinical chemistry, healthcare utilisation and harms. All outcomes were measured at baseline and 12 weeks, with long-term HRQoL and adherence also collected at six months follow-up. A nested qualitative study explored experience and impact of using Kidney BEAM. Results 340 participants were randomised to Kidney BEAM (n = 173) and waiting list (n = 167) groups. There were 96 (55%) and 89 (53%) males in the intervention and waiting list groups respectively, and the mean (SD) age was 53 (14) years in both groups. Ethnicity, body mass, CKD stage, and history of diabetes and hypertension were comparable across groups. The mean (SD) of the MCS was similar in both groups, 44.7 (10.8) and 45.9 (10.6) in the intervention and waiting list groups respectively. Conclusion Results from this trial will establish whether the Kidney BEAM self management programme is a cost-effective method of enhancing mental and physical wellbeing of people with CKD.

KW - Adult

KW - Exercise

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Quality of Life

KW - Renal Insufficiency, Chronic/therapy

KW - Telemedicine

KW - Waiting Lists

U2 - 10.1186/s12882-023-03173-7

DO - 10.1186/s12882-023-03173-7

M3 - Article

C2 - 37131125

SN - 1471-2369

VL - 24

JO - BMC Nephrology

JF - BMC Nephrology

IS - 1

M1 - 122

ER -

Walklin CG, Young HML, Asghari E, Bhandari S, Billany RE, Bishop N et al. The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM). BMC Nephrology. 2023 Mai 2;24(1):122. doi: 10.1186/s12882-023-03173-7