The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters

Hanan Ali; Gani Koza; Rwoaa Hameed; Richard Rowles; Carys Davies; Juma'a R. Al-Dulayymi; Christopher Gwenin; Mark Baird

doi:10.1016/j.tet.2016.08.089

The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters

Hanan Ali
, Gani Koza
, Rwoaa Hameed
, Richard Rowles
, Carys Davies
, Juma'a R. Al-Dulayymi
, Christopher Gwenin
, Mark Baird

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

260 Wedi eu Llwytho i Lawr (Pure)

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Routes to single enantiomers of hydroxy, methoxy and ketomycolic acids containing an α-methyl-trans-alkene unit as well as related trehalose, glucose, arabinose and glycerol esters are described. In serodiagnostic assays to detect antibodies to mycobacterial lipids, the trehalose esters give higher responses to the serum of patients with culture positive tuberculosis than to that of culture negative patients.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	7143-7158
Nifer y tudalennau	15
Cyfnodolyn	Tetrahedron
Cyfrol	72
Rhif cyhoeddi	45
Dyddiad ar-lein cynnar	14 Medi 2016
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.tet.2016.08.089
Statws	Cyhoeddwyd - 10 Tach 2016

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10.1016/j.tet.2016.08.089

1-s2 0-S0040402016308845-mainProflen, 848 KB

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title = "The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters",

abstract = "Routes to single enantiomers of hydroxy, methoxy and ketomycolic acids containing an α-methyl-trans-alkene unit as well as related trehalose, glucose, arabinose and glycerol esters are described. In serodiagnostic assays to detect antibodies to mycobacterial lipids, the trehalose esters give higher responses to the serum of patients with culture positive tuberculosis than to that of culture negative patients.",

author = "Hanan Ali and Gani Koza and Rwoaa Hameed and Richard Rowles and Carys Davies and Al-Dulayymi, \{Juma'a R.\} and Christopher Gwenin and Mark Baird",

year = "2016",

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doi = "10.1016/j.tet.2016.08.089",

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T1 - The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters

AU - Ali, Hanan

AU - Koza, Gani

AU - Hameed, Rwoaa

AU - Rowles, Richard

AU - Davies, Carys

AU - Al-Dulayymi, Juma'a R.

AU - Gwenin, Christopher

AU - Baird, Mark

PY - 2016/11/10

Y1 - 2016/11/10

N2 - Routes to single enantiomers of hydroxy, methoxy and ketomycolic acids containing an α-methyl-trans-alkene unit as well as related trehalose, glucose, arabinose and glycerol esters are described. In serodiagnostic assays to detect antibodies to mycobacterial lipids, the trehalose esters give higher responses to the serum of patients with culture positive tuberculosis than to that of culture negative patients.

AB - Routes to single enantiomers of hydroxy, methoxy and ketomycolic acids containing an α-methyl-trans-alkene unit as well as related trehalose, glucose, arabinose and glycerol esters are described. In serodiagnostic assays to detect antibodies to mycobacterial lipids, the trehalose esters give higher responses to the serum of patients with culture positive tuberculosis than to that of culture negative patients.

U2 - 10.1016/j.tet.2016.08.089

DO - 10.1016/j.tet.2016.08.089

M3 - Article

SN - 0040-4020

VL - 72

SP - 7143

EP - 7158

JO - Tetrahedron

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IS - 45

ER -

The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters

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Mynediad at Ddogfen

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