n 2017 we reported a paradoxical decrease in cerebral blood flow (CBF) in response to hypoxia within the posterior cingulate cortex, and then in 2021 we found an apparent hypoxia induced reversal of neurovascular coupling within this region. Since then we have been further investigating this phenomenon, using magnetic resonance spectroscopy based techniques. I will describe three recent experiments by my PhD Student Matthew Rogan further exploring the neurometabolic alterations associated with this decrease in CBF the PCC during hypoxia.