Personal profile
Overview
My research focuses on the biology of squamous carcinomas, a group of diseases with similar genetic origin and, conceivably, similar vulnerabilities. I am particularly interested in identifying the origins of the heterogeneity that is so prominent in lung squamous cell carcinomas (LUSC), modelling and investigating precancerous stages and identifying vulnerabilities associated to the different LUSC subtypes.
In addition, I have a special interest in developing human models of cancer to reduce the number of animals in research. To do that, we use human cells and organoids to model squamous carcinomas.
Education/Academic qualification
Postgraduate, PhD, Involvement of polyamine metabolism in mouse pregnancy, University of Murcia
1 Oct 2002 → 16 Mar 2007
Award Date: 16 Mar 2007
Undergraduate, BSc, Pharmacy, University of Valencia
1 Oct 1995 → 1 Sept 1998
Award Date: 1 Sept 1998
External positions
Institute Fellow, Cancer Research UK Manchester Institute
4 Mar 2019 → 28 Feb 2025
Research Associate, National Heart and Lung Research Institute, Imperial College London
1 Feb 2017 → 28 Feb 2019
Postdoctoral Scientist, The Francis Crick Institute
12 Jul 2011 → 31 Jan 2017
Postdoctoral Fellow, University of Murcia
1 Jul 2010 → 30 Jun 2011
Postdoctoral Fellow, Cancer Research UK Cambridge Institute, University of Cambridge
7 May 2007 → 30 Jun 2010
Keywords
- QH301 Biology
- Cancer biology
- Colorectal cancer
- Lung Cancer
- Cancer genetics
Fingerprint
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Collaborations and top research areas from the last five years
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A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma
Ogden, J., Sellers, R., Sahoo, S., Oojageer, A., Chaturvedi, A., Dive, C. & Lopez-Garcia, C., 4 Apr 2025, In: Nature Communications. 16, 1, p. 3215Research output: Contribution to journal › Article › peer-review
Open Access -
Studying a human genetic model of lung squamous cell carcinoma with organotypic cultures and xenografts uncovers distinct advantages of each system and implicates NOTCH1 loss in tumour development
Ogden, J., Sellers, R., Oojageer, A., Sahoo, S., Dive, C. & Lopez-Garcia, C., 1 Sept 2025, (Accepted/In press) In: bioRxiv.Research output: Contribution to journal › Article
Open AccessFile2 Downloads (Pure) -
Interrogating the precancerous evolution of pathway dysfunction in lung squamous cell carcinoma using XTABLE
Roberts, M., Ogden, J., Hossain, A. S. M., Chaturvedi, A., Kerr, A. R. W., Dive, C., Beane, J. E. & Lopez-Garcia, C., 24 Mar 2023, In: Elife. 12Research output: Contribution to journal › Article › peer-review
Open Access -
Antizyme Inhibitor 2-Deficient Mice Exhibit Altered Brain Polyamine Levels and Reduced Locomotor Activity
Lambertos, A., Nuñez-Sanchez, M. A., López-García, C., López-Contreras, A. J., Ramos-Molina, B. & Peñafiel, R., 21 Dec 2022, In: Biomolecules. 13, 1Research output: Contribution to journal › Article › peer-review
Open Access -
CEACAM5 is an IL-13-regulated epithelial gene that mediates transcription in type-2 (T2) high severe asthma
Mumby, S., Kermani, N. Z., Garnett, J. P., Pavlidis, S., Wilson, S. J., Howarth, P. J., Thomas, M. J., Adcock, I. M. & López-García, C., 1 Nov 2022, In: Allergy. 77, 11, p. 3463-3466 4 p.Research output: Contribution to journal › Article › peer-review
Open Access
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Oncologie (Journal)
Lopez-Garcia, C. (Editorial board member)
2025Activity: Publication peer-review and editorial work › Publication peer-review