I am a molecular neurobiologist interested in understanding ­the mechanisms that underlie aging and neurodegeneration. My work uses the power of Drosophila melanogaster genetics coupled with an array of molecular, cellular, behavioural, imaging and bioinformatics approaches to better understand the molecular processes that define normal aging and identify how these processes are altered in pathological aging and neurodegenerative diseases.

Molecular Biology | Animal models | Neurodegeneration |Aging | Alzheimer's Disease

We are interested in understanding selective vulnerability of neurons to pathogenic proteins such as the tangle-forming protein, tau, in Alzheimer's Disease.  This involves characterising neuronal vulnerability to tau variants and identifying genes that may mediate vulnerability or resistance to tau.