2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

R. Wilson; R. Ainscough; K. Anderson; C. Baynes; M. Berks; J. Bonfield; J. Burton; M. Connell; T. Copsey; J. Cooper; A. Coulson; M. Craxton; S. Dear; Z. Du; R. Durbin; A. Favello; A. Fraser; L. Fulton; A. Gardner; P. Green; T. Hawkins; L. Hillier; M. Jier; L Johnston; M. Jones; J. Kershaw; J. Kirsten; N. Laisstert; P. Latreille; J. Lightning; C. Lloyd; B. Mortimore; M. O'Callaghan; J. Parsons; C. Percy; L. Rifken; A. Roopra; D. Saunders; R. Shownkeen; M. Sims; N. Smaldon; A. Smith; M. Smith; E. Sonnhammer; R. Staden; J. Sulston; J. Thierry-Mieg; K. Thomas; M. Vaudin; K. Vaughan; R. Waterston; A. Watson; L. Weinstock; J. Wilkinson-Sproatt; P. Wohldman

doi:10.1038/368032a0

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

R. Wilson
, R. Ainscough
, K. Anderson
, C. Baynes
, M. Berks
, J. Bonfield
, J. Burton
, M. Connell
, T. Copsey
, J. Cooper
, A. Coulson
, M. Craxton
, S. Dear
, Z. Du
, R. Durbin
, A. Favello
, A. Fraser
, L. Fulton
, A. Gardner
, P. Green

T. Hawkins, L. Hillier, M. Jier, L Johnston, M. Jones, J. Kershaw, J. Kirsten, N. Laisstert, P. Latreille, J. Lightning, C. Lloyd, B. Mortimore, M. O'Callaghan, J. Parsons, C. Percy , L. Rifken, A. Roopra, D. Saunders, R. Shownkeen, M. Sims, N. Smaldon, A. Smith, M. Smith, E. Sonnhammer, R. Staden, J. Sulston, J. Thierry-Mieg, K. Thomas, M. Vaudin, K. Vaughan, R. Waterston, A. Watson, L. Weinstock, J. Wilkinson-Sproatt, P. Wohldman

School of Environmental & Natural Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

As part of our effort to sequence the 100-megabase (Mb) genome of the nematode Caenorhabditis elegans, we have completed the nucleotide sequence of a contiguous 2,181,032 base pairs in the central gene cluster of chromosome III. Analysis of the finished sequence has indicated an average density of about one gene per five kilobases; comparison with the public sequence databases reveals similarities to previously known genes for about one gene in three. In addition, the genomic sequence contains several intriguing features, including putative gene duplications and a variety of other repeats with potential evolutionary implications.

Original language	English
Pages (from-to)	32-8
Number of pages	7
Journal	Nature
Volume	368
Issue number	6466
DOIs	https://doi.org/10.1038/368032a0
Publication status	Published - 3 Mar 1994

Keywords

Animals
Caenorhabditis elegans/genetics
Chromosome Mapping
Databases, Factual
Genes, Helminth
Genes, Homeobox
Molecular Sequence Data
Multigene Family
RNA, Transfer/genetics
Repetitive Sequences, Nucleic Acid
Sequence Analysis, DNA

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10.1038/368032a0

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Wilson, R., Ainscough, R., Anderson, K., Baynes, C., Berks, M., Bonfield, J., Burton, J., Connell, M., Copsey, T., Cooper, J., Coulson, A., Craxton, M., Dear, S., Du, Z., Durbin, R., Favello, A., Fraser, A., Fulton , L., Gardner, A., ... Wohldman, P. (1994). 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature, 368(6466), 32-8. https://doi.org/10.1038/368032a0

@article{330622c6d6a846c498936547587502fd,

title = "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans",

abstract = "As part of our effort to sequence the 100-megabase (Mb) genome of the nematode Caenorhabditis elegans, we have completed the nucleotide sequence of a contiguous 2,181,032 base pairs in the central gene cluster of chromosome III. Analysis of the finished sequence has indicated an average density of about one gene per five kilobases; comparison with the public sequence databases reveals similarities to previously known genes for about one gene in three. In addition, the genomic sequence contains several intriguing features, including putative gene duplications and a variety of other repeats with potential evolutionary implications.",

keywords = "Animals, Caenorhabditis elegans/genetics, Chromosome Mapping, Databases, Factual, Genes, Helminth, Genes, Homeobox, Molecular Sequence Data, Multigene Family, RNA, Transfer/genetics, Repetitive Sequences, Nucleic Acid, Sequence Analysis, DNA",

author = "R. Wilson and R. Ainscough and K. Anderson and C. Baynes and M. Berks and J. Bonfield and J. Burton and M. Connell and T. Copsey and J. Cooper and A. Coulson and M. Craxton and S. Dear and Z. Du and R. Durbin and A. Favello and A. Fraser and L. Fulton and A. Gardner and P. Green and T. Hawkins and L. Hillier and M. Jier and L Johnston and M. Jones and J. Kershaw and J. Kirsten and N. Laisstert and P. Latreille and J. Lightning and C. Lloyd and B. Mortimore and M. O'Callaghan and J. Parsons and C. Percy and L. Rifken and A. Roopra and D. Saunders and R. Shownkeen and M. Sims and N. Smaldon and A. Smith and M. Smith and E. Sonnhammer and R. Staden and J. Sulston and J. Thierry-Mieg and K. Thomas and M. Vaudin and K. Vaughan and R. Waterston and A. Watson and L. Weinstock and J. Wilkinson-Sproatt and P. Wohldman",

year = "1994",

month = mar,

day = "3",

doi = "10.1038/368032a0",

language = "English",

volume = "368",

pages = "32--8",

journal = "Nature",

issn = "0028-0836",

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number = "6466",

}

Wilson, R, Ainscough, R, Anderson, K, Baynes, C, Berks, M, Bonfield, J, Burton, J, Connell, M, Copsey, T, Cooper, J, Coulson, A, Craxton, M, Dear, S, Du, Z, Durbin, R, Favello, A, Fraser, A, Fulton , L, Gardner, A, Green, P, Hawkins, T, Hillier, L, Jier, M, Johnston, L, Jones, M, Kershaw, J, Kirsten, J, Laisstert, N, Latreille, P, Lightning, J, Lloyd, C, Mortimore, B, O'Callaghan, M, Parsons, J, Percy , C, Rifken, L, Roopra, A, Saunders, D, Shownkeen, R, Sims, M, Smaldon, N, Smith, A, Smith, M, Sonnhammer, E, Staden, R, Sulston, J, Thierry-Mieg, J, Thomas, K, Vaudin, M, Vaughan, K, Waterston, R, Watson, A, Weinstock, L, Wilkinson-Sproatt, J & Wohldman, P 1994, '2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans', Nature, vol. 368, no. 6466, pp. 32-8. https://doi.org/10.1038/368032a0

TY - JOUR

T1 - 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

AU - Wilson, R.

AU - Ainscough, R.

AU - Anderson, K.

AU - Baynes, C.

AU - Berks, M.

AU - Bonfield, J.

AU - Burton, J.

AU - Connell, M.

AU - Copsey, T.

AU - Cooper, J.

AU - Coulson, A.

AU - Craxton, M.

AU - Dear, S.

AU - Du, Z.

AU - Durbin, R.

AU - Favello, A.

AU - Fraser, A.

AU - Fulton , L.

AU - Gardner, A.

AU - Green, P.

AU - Hawkins, T.

AU - Hillier, L.

AU - Jier, M.

AU - Johnston, L

AU - Jones, M.

AU - Kershaw, J.

AU - Kirsten, J.

AU - Laisstert, N.

AU - Latreille, P.

AU - Lightning, J.

AU - Lloyd, C.

AU - Mortimore, B.

AU - O'Callaghan, M.

AU - Parsons, J.

AU - Percy , C.

AU - Rifken, L.

AU - Roopra, A.

AU - Saunders, D.

AU - Shownkeen, R.

AU - Sims, M.

AU - Smaldon, N.

AU - Smith, A.

AU - Smith, M.

AU - Sonnhammer, E.

AU - Staden, R.

AU - Sulston, J.

AU - Thierry-Mieg, J.

AU - Thomas, K.

AU - Vaudin, M.

AU - Vaughan, K.

AU - Waterston, R.

AU - Watson, A.

AU - Weinstock, L.

AU - Wilkinson-Sproatt, J.

AU - Wohldman, P.

PY - 1994/3/3

Y1 - 1994/3/3

N2 - As part of our effort to sequence the 100-megabase (Mb) genome of the nematode Caenorhabditis elegans, we have completed the nucleotide sequence of a contiguous 2,181,032 base pairs in the central gene cluster of chromosome III. Analysis of the finished sequence has indicated an average density of about one gene per five kilobases; comparison with the public sequence databases reveals similarities to previously known genes for about one gene in three. In addition, the genomic sequence contains several intriguing features, including putative gene duplications and a variety of other repeats with potential evolutionary implications.

AB - As part of our effort to sequence the 100-megabase (Mb) genome of the nematode Caenorhabditis elegans, we have completed the nucleotide sequence of a contiguous 2,181,032 base pairs in the central gene cluster of chromosome III. Analysis of the finished sequence has indicated an average density of about one gene per five kilobases; comparison with the public sequence databases reveals similarities to previously known genes for about one gene in three. In addition, the genomic sequence contains several intriguing features, including putative gene duplications and a variety of other repeats with potential evolutionary implications.

KW - Animals

KW - Caenorhabditis elegans/genetics

KW - Chromosome Mapping

KW - Databases, Factual

KW - Genes, Helminth

KW - Genes, Homeobox

KW - Molecular Sequence Data

KW - Multigene Family

KW - RNA, Transfer/genetics

KW - Repetitive Sequences, Nucleic Acid

KW - Sequence Analysis, DNA

U2 - 10.1038/368032a0

DO - 10.1038/368032a0

M3 - Article

C2 - 7906398

SN - 0028-0836

VL - 368

SP - 32

EP - 38

JO - Nature

JF - Nature

IS - 6466

ER -

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

Abstract

Keywords

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