3D Pattern of brain abnormalisiteis in William syndrome visualized using tensor-based morphometry

  • Ming-Chang Chiang
  • , Allan Reiss
  • , Agatha D Lee
  • , Ursula Bellugi
  • , Albert M. Galaburda
  • , Julie R. Korenberg
  • , Debra Mills
  • , Arthur W. Toga
  • , Paul M. Thompson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Williams syndrome (WS) is a neurodevelopmental disorder associated with deletion of ∼ 20 contiguous genes in chromosome band 7q11.23. Individuals with WS exhibit mild to moderate mental retardation, but are relatively more proficient in specific language and musical abilities. We used tensor-based morphometry (TBM) to visualize the complex pattern of gray/white matter reductions in WS, based on fluid registration of structural brain images.
    Original languageEnglish
    Pages (from-to)1096-1109
    Number of pages16
    JournalNeuroimage
    Volume36
    Issue number4
    DOIs
    Publication statusPublished - 2007

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