Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Ali Kermanizadeh; Trine Berthing; Ewa Guzniczak; Melanie Wheeldon; Graeme Whyte; Ulla Vogel; Wolfgang Moritz; Vicki Stone

doi:10.1186/s12989-019-0326-0

Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Ali Kermanizadeh
, Trine Berthing
, Ewa Guzniczak
, Melanie Wheeldon
, Graeme Whyte
, Ulla Vogel
, Wolfgang Moritz
, Vicki Stone

Heriot-Watt University, Edinburgh
National Research Centre for the Working Environment, Copenhagen
InSphero AG, Schlieren

Research output: Contribution to journal › Article › peer-review

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Original language	English
Article number	42
Journal	Particle and fibre toxicology
Volume	16
Issue number	1
Early online date	19 Nov 2019
DOIs	https://doi.org/10.1186/s12989-019-0326-0
Publication status	Published - 19 Nov 2019
Externally published	Yes

Keywords

3D primary human multi-cellular liver microtissue
In vitro hepatotoxicology
In vitro vs
Kupffer cells
in vivo comparisons

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10.1186/s12989-019-0326-0Licence: CC BY

2020 Assessment of nanomaterialFinal published version, 1.95 MBLicence: CC BY

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Kermanizadeh, A., Berthing, T., Guzniczak, E., Wheeldon, M., Whyte, G., Vogel, U., Moritz, W., & Stone, V. (2019). Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate. Particle and fibre toxicology, 16(1), Article 42. https://doi.org/10.1186/s12989-019-0326-0

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keywords = "3D primary human multi-cellular liver microtissue, In vitro hepatotoxicology, In vitro vs, Kupffer cells, in vivo comparisons",

author = "Ali Kermanizadeh and Trine Berthing and Ewa Guzniczak and Melanie Wheeldon and Graeme Whyte and Ulla Vogel and Wolfgang Moritz and Vicki Stone",

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Kermanizadeh, A, Berthing, T, Guzniczak, E, Wheeldon, M, Whyte, G, Vogel, U, Moritz, W & Stone, V 2019, 'Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate', Particle and fibre toxicology, vol. 16, no. 1, 42. https://doi.org/10.1186/s12989-019-0326-0

Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate. / Kermanizadeh, Ali; Berthing, Trine; Guzniczak, Ewa et al.
In: Particle and fibre toxicology, Vol. 16, No. 1, 42, 19.11.2019.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

AU - Kermanizadeh, Ali

AU - Berthing, Trine

AU - Guzniczak, Ewa

AU - Wheeldon, Melanie

AU - Whyte, Graeme

AU - Vogel, Ulla

AU - Moritz, Wolfgang

AU - Stone, Vicki

PY - 2019/11/19

Y1 - 2019/11/19

KW - 3D primary human multi-cellular liver microtissue

KW - In vitro hepatotoxicology

KW - In vitro vs

KW - Kupffer cells

KW - in vivo comparisons

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DO - 10.1186/s12989-019-0326-0

M3 - Article

C2 - 31739797

SN - 1743-8977

VL - 16

JO - Particle and fibre toxicology

JF - Particle and fibre toxicology

IS - 1

M1 - 42

ER -

Kermanizadeh A, Berthing T, Guzniczak E, Wheeldon M, Whyte G, Vogel U et al. Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate. Particle and fibre toxicology. 2019 Nov 19;16(1):42. Epub 2019 Nov 19. doi: 10.1186/s12989-019-0326-0

Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

Keywords

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