BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation

Cristiano Palego

doi:10.1109/MWSYM.2016.7540266

BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation

Cristiano Palego

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Abstract

A novel microfluidic biosensing platform based on Bipolar-Complementary Oxide Semiconductor (BiCMOS) technology is presented. The device relies on a quadruple electrode system and a microfluidic channel that are directly integrated into the back-end-of-line (BEOL) of the BiCMOS stack. For proof of concept repeatable electrical trapping of single SW620 (colon cancer) cells in the quadruple electrode system is initially demonstrated. Additionally, for the first time a microwave intermodulation technique is used for high sensitivity dielectric spectroscopy, which could pave the way to label-free monitoring of intracellular processes and manipulation such as electroporation.

Original language	English
Title of host publication	Microwave Symposium (IMS), 2016 IEEE MTT-S International
DOIs	https://doi.org/10.1109/MWSYM.2016.7540266
Publication status	Published - 11 Aug 2016

Keywords

Microfluidics, Microwave theory and techniques, Charge carrier processes, BiCMOS integrated circuits, Electrodes, Monitoring, Radio frequency

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/MWSYM.2016.7540266

IMS2016_Bangor7Accepted author manuscript, 956 KB

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title = "BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation",

abstract = "A novel microfluidic biosensing platform based on Bipolar-Complementary Oxide Semiconductor (BiCMOS) technology is presented. The device relies on a quadruple electrode system and a microfluidic channel that are directly integrated into the back-end-of-line (BEOL) of the BiCMOS stack. For proof of concept repeatable electrical trapping of single SW620 (colon cancer) cells in the quadruple electrode system is initially demonstrated. Additionally, for the first time a microwave intermodulation technique is used for high sensitivity dielectric spectroscopy, which could pave the way to label-free monitoring of intracellular processes and manipulation such as electroporation.",

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doi = "10.1109/MWSYM.2016.7540266",

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N2 - A novel microfluidic biosensing platform based on Bipolar-Complementary Oxide Semiconductor (BiCMOS) technology is presented. The device relies on a quadruple electrode system and a microfluidic channel that are directly integrated into the back-end-of-line (BEOL) of the BiCMOS stack. For proof of concept repeatable electrical trapping of single SW620 (colon cancer) cells in the quadruple electrode system is initially demonstrated. Additionally, for the first time a microwave intermodulation technique is used for high sensitivity dielectric spectroscopy, which could pave the way to label-free monitoring of intracellular processes and manipulation such as electroporation.

AB - A novel microfluidic biosensing platform based on Bipolar-Complementary Oxide Semiconductor (BiCMOS) technology is presented. The device relies on a quadruple electrode system and a microfluidic channel that are directly integrated into the back-end-of-line (BEOL) of the BiCMOS stack. For proof of concept repeatable electrical trapping of single SW620 (colon cancer) cells in the quadruple electrode system is initially demonstrated. Additionally, for the first time a microwave intermodulation technique is used for high sensitivity dielectric spectroscopy, which could pave the way to label-free monitoring of intracellular processes and manipulation such as electroporation.

KW - Microfluidics, Microwave theory and techniques, Charge carrier processes, BiCMOS integrated circuits, Electrodes, Monitoring, Radio frequency

U2 - 10.1109/MWSYM.2016.7540266

DO - 10.1109/MWSYM.2016.7540266

M3 - Conference contribution

BT - Microwave Symposium (IMS), 2016 IEEE MTT-S International

ER -

BiCMOS microfluidic sensor for single cell label-free monitoring through microwave intermodulation

Abstract

Keywords

UN SDGs

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