Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

Lin Zhou; Chen Liu; Zhengbo Sun; Hongju Mao; Lin Zhang; Xuefeng Yu; Jianlong Zhao; Xianfeng Chen

doi:10.1016/j.bios.2019.04.044

Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

Lin Zhou, Chen Liu, Zhengbo Sun, Hongju Mao, Lin Zhang, Xuefeng Yu, Jianlong Zhao, Xianfeng Chen

School of Computer Science & Engineering

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Abstract

We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating
ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.

Original language	English
Pages (from-to)	140-147
Number of pages	8
Journal	Biosensors and Bioelectronics
Volume	137
Early online date	25 Apr 2019
DOIs	https://doi.org/10.1016/j.bios.2019.04.044
Publication status	Published - 15 Jul 2019

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2019-Black phosphorus based fiber opticAccepted author manuscript, 1.17 MBLicence: CC BY-NC-ND

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@article{22a4ee73c8984564ba925072b90fb695,

title = "Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis",

abstract = "We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.",

author = "Lin Zhou and Chen Liu and Zhengbo Sun and Hongju Mao and Lin Zhang and Xuefeng Yu and Jianlong Zhao and Xianfeng Chen",

note = "Supplementary data related to this article can be found at https://doi.org/10.1016/j.bios.2019.04.044. The authors acknowledge support from the projects of EU FP7 PIRSES-GA-2013-612267 (iPhoto Bio, European Commission); the S{\^e}r Cymru NRN Fund (NRN097, United Kingdom); the National Natural Science Foundation of China (No. 61571429 and 61801464, China).",

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doi = "10.1016/j.bios.2019.04.044",

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AU - Zhou, Lin

AU - Liu, Chen

AU - Sun, Zhengbo

AU - Mao, Hongju

AU - Zhang, Lin

AU - Yu, Xuefeng

AU - Zhao, Jianlong

AU - Chen, Xianfeng

N1 - Supplementary data related to this article can be found at https://doi.org/10.1016/j.bios.2019.04.044. The authors acknowledge support from the projects of EU FP7 PIRSES-GA-2013-612267 (iPhoto Bio, European Commission); the Sêr Cymru NRN Fund (NRN097, United Kingdom); the National Natural Science Foundation of China (No. 61571429 and 61801464, China).

PY - 2019/7/15

Y1 - 2019/7/15

N2 - We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.

AB - We propose the first black phosphorus (BP) – fiber optic biosensor for ultrasensitive diagnosis of human neuronspecific enolase (NSE) cancer biomarkers. A novel optical-nano configuration has been exploited by integrating BP nanosheets with a largely tilted fiber grating (BP-TFG), where the BP is bio-functionalized by the poly-Llysine acting as a critical cross-linker to facilitate bio-nano-photonic interface with extremely enhanced lightmatter interaction. BP nanosheets are synthesized by a liquid ultrasonication-based exfoliation and deposited on fiber device by an in-situ layer-by-layer method. The BP-induced optical modulation effects in terms of thicknesstunable feature, polarization-dependence and enhanced light-matter interaction are experimentally investigated. The anti-NSE immobilized BP-TFG biosensor has been implemented to detect NSE biomarkers demonstrating ultrahigh sensitivity with limit of detection down to 1.0 pg/mL, which is 4 orders magnitude lower than NSE cutoff value of small cell lung cancer. The enhanced sensitivity of BP-TFG is 100-fold higher than graphene oxide or AuNPs based biosensors. We believe that BP-fiber optic configuration opens a new bio-nano-photonic platform for the applications in healthcare, biomedical, food safety and environmental monitoring.

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JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

ER -

Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis

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