Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target

Helena Robinson; Ramsay J McFarlane; Jane A Wakeman

doi:10.1016/j.trecan.2020.01.014

Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target

Helena Robinson, Ramsay J McFarlane, Jane A Wakeman

School of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here, recent advances targeting Brachyury in chordoma are discussed and how these might open doors to the targeting of other, more common cancer types.

Original language	English
Pages (from-to)	271-273
Number of pages	3
Journal	Trends in cancer
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.trecan.2020.01.014
Publication status	Published - Apr 2020

Keywords

Antineoplastic Agents/pharmacology
Biomarkers, Tumor/analysis
Bone Neoplasms/diagnosis
Chordoma/diagnosis
Computer Simulation
Crystallography, X-Ray
Drug Discovery
Fetal Proteins/analysis
Humans
Models, Molecular
Protein Domains
T-Box Domain Proteins/analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trecan.2020.01.014

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title = "Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target",

abstract = "New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here, recent advances targeting Brachyury in chordoma are discussed and how these might open doors to the targeting of other, more common cancer types.",

keywords = "Antineoplastic Agents/pharmacology, Biomarkers, Tumor/analysis, Bone Neoplasms/diagnosis, Chordoma/diagnosis, Computer Simulation, Crystallography, X-Ray, Drug Discovery, Fetal Proteins/analysis, Humans, Models, Molecular, Protein Domains, T-Box Domain Proteins/analysis",

author = "Helena Robinson and McFarlane, {Ramsay J} and Wakeman, {Jane A}",

year = "2020",

month = apr,

doi = "10.1016/j.trecan.2020.01.014",

language = "English",

volume = "6",

pages = "271--273",

journal = "Trends in cancer",

issn = "2405-8033",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target

AU - Robinson, Helena

AU - McFarlane, Ramsay J

AU - Wakeman, Jane A

PY - 2020/4

Y1 - 2020/4

N2 - New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here, recent advances targeting Brachyury in chordoma are discussed and how these might open doors to the targeting of other, more common cancer types.

AB - New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here, recent advances targeting Brachyury in chordoma are discussed and how these might open doors to the targeting of other, more common cancer types.

KW - Antineoplastic Agents/pharmacology

KW - Biomarkers, Tumor/analysis

KW - Bone Neoplasms/diagnosis

KW - Chordoma/diagnosis

KW - Computer Simulation

KW - Crystallography, X-Ray

KW - Drug Discovery

KW - Fetal Proteins/analysis

KW - Humans

KW - Models, Molecular

KW - Protein Domains

KW - T-Box Domain Proteins/analysis

U2 - 10.1016/j.trecan.2020.01.014

DO - 10.1016/j.trecan.2020.01.014

M3 - Article

C2 - 32209441

SN - 2405-8033

VL - 6

SP - 271

EP - 273

JO - Trends in cancer

JF - Trends in cancer

IS - 4

ER -

Brachyury: Strategies for Drugging an Intractable Cancer Therapeutic Target

Abstract

Keywords

UN SDGs

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