Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis

Charlotte Van Netten; Kirtana Vallabhaneni; Ben  Hardwick; Dilly Anumba; Anette Briley; Peter Collins; Rachel Collins; Elizabeth Deja; Efstathia Gkioni; Gillian Gyte; Helen  Hickey; Kim Hinshaw; Dyfrig Hughes; Sion Kenyon; Tina Lavender; Shireen Meher; Catrin Plumpton; Stephen Robson; Anna Rosala-Hallas; Egle Saviciute; Andrew Shennan; Dimitrios Siassakos; Jim Thornton; Elaine Willis; Kerry Woolfall; Carrol Gamble; Andrew  Weeks

doi:10.1136/bmjopen-2025-101255

Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis

Charlotte Van Netten
, Kirtana Vallabhaneni
, Ben Hardwick
, Dilly Anumba
, Anette Briley
, Peter Collins
, Rachel Collins
, Elizabeth Deja
, Efstathia Gkioni
, Gillian Gyte
, Helen Hickey
, Kim Hinshaw
, Dyfrig Hughes
, Sion Kenyon
, Tina Lavender
, Shireen Meher
, Catrin Plumpton
, Stephen Robson
, Anna Rosala-Hallas
, Egle Saviciute

Andrew Shennan, Dimitrios Siassakos, Jim Thornton, Elaine Willis, Kerry Woolfall, Carrol Gamble, Andrew Weeks

North Wales Medical School

Liverpool Clinical Trials Research Centre
University of Liverpool
University of Liverpool
University of Sheffield
Flinders University, Adelaide
Cardiff University
University Hospital of Wales
National Childbirth Trust
Sunderland Royal Hospital
Liverpool School of Tropical Medicine
University of Sydney
Newcastle University
Kings College London
University College London
University of Nottingham
Liverpool Womens Hospital Foundation Trust

Research output: Contribution to journal › Article › peer-review

30 Downloads (Pure)

Original language	English
Article number	e101255
Journal	BMJ Open
Volume	15
Issue number	5
Early online date	8 May 2025
DOIs	https://doi.org/10.1136/bmjopen-2025-101255
Publication status	Published - 8 May 2025

Access to Document

10.1136/bmjopen-2025-101255

e101255.fullFinal published version, 949 KBLicence: CC BY

Cite this

Van Netten, C., Vallabhaneni, K., Hardwick, B., Anumba, D., Briley, A., Collins, P., Collins, R., Deja, E., Gkioni, E., Gyte, G., Hickey, H., Hinshaw, K., Hughes, D., Kenyon, S., Lavender, T., Meher, S., Plumpton, C., Robson, S., Rosala-Hallas, A., ... Weeks , A. (2025). Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis. BMJ Open, 15(5), Article e101255. https://doi.org/10.1136/bmjopen-2025-101255

@article{3aae5d3953e04cfeac5de0b53df18aa2,

title = "Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis",

author = "\{Van Netten\}, Charlotte and Kirtana Vallabhaneni and Ben Hardwick and Dilly Anumba and Anette Briley and Peter Collins and Rachel Collins and Elizabeth Deja and Efstathia Gkioni and Gillian Gyte and Helen Hickey and Kim Hinshaw and Dyfrig Hughes and Sion Kenyon and Tina Lavender and Shireen Meher and Catrin Plumpton and Stephen Robson and Anna Rosala-Hallas and Egle Saviciute and Andrew Shennan and Dimitrios Siassakos and Jim Thornton and Elaine Willis and Kerry Woolfall and Carrol Gamble and Andrew Weeks",

year = "2025",

month = may,

day = "8",

doi = "10.1136/bmjopen-2025-101255",

language = "English",

volume = "15",

journal = "BMJ Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

number = "5",

}

Van Netten, C, Vallabhaneni, K, Hardwick, B, Anumba, D, Briley, A, Collins, P, Collins, R, Deja, E, Gkioni, E, Gyte, G, Hickey, H, Hinshaw, K, Hughes, D, Kenyon, S, Lavender, T, Meher, S, Plumpton, C, Robson, S, Rosala-Hallas, A, Saviciute, E, Shennan, A, Siassakos, D, Thornton, J, Willis, E, Woolfall, K, Gamble, C & Weeks , A 2025, 'Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis', BMJ Open, vol. 15, no. 5, e101255. https://doi.org/10.1136/bmjopen-2025-101255

Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis. / Van Netten, Charlotte; Vallabhaneni, Kirtana; Hardwick, Ben et al.
In: BMJ Open, Vol. 15, No. 5, e101255, 08.05.2025.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Carboprost versus Oxytocin as the first-line treatment of primary postpartum haemorrhage (COPE): protocol for a phase IV, double-blind, double-dummy, randomised controlled trial and economic analysis

AU - Van Netten, Charlotte

AU - Vallabhaneni, Kirtana

AU - Hardwick, Ben

AU - Anumba, Dilly

AU - Briley, Anette

AU - Collins, Peter

AU - Collins, Rachel

AU - Deja, Elizabeth

AU - Gkioni, Efstathia

AU - Gyte, Gillian

AU - Hickey, Helen

AU - Hinshaw, Kim

AU - Hughes, Dyfrig

AU - Kenyon, Sion

AU - Lavender, Tina

AU - Meher, Shireen

AU - Plumpton, Catrin

AU - Robson, Stephen

AU - Rosala-Hallas, Anna

AU - Saviciute, Egle

AU - Shennan, Andrew

AU - Siassakos, Dimitrios

AU - Thornton, Jim

AU - Willis, Elaine

AU - Woolfall, Kerry

AU - Gamble, Carrol

AU - Weeks , Andrew

PY - 2025/5/8

Y1 - 2025/5/8

U2 - 10.1136/bmjopen-2025-101255

DO - 10.1136/bmjopen-2025-101255

M3 - Article

SN - 2044-6055

VL - 15

JO - BMJ Open

JF - BMJ Open

IS - 5

M1 - e101255

ER -