Compact Nanosecond Bipolar Pulse Generator for On-chip Modulation of Biological Response

Ilan Davies; Nissar Karim; Amira Eltokhy; Lynn Carr; Chris Hancock; Cristiano Palego; Emre C. Durmaz; Canan Baristiran Kaynak; Mehmet Kaynak; Arnaud Pothier; Delia Arnaud-Cosmos; Philippe Leveque

Compact Nanosecond Bipolar Pulse Generator for On-chip Modulation of Biological Response

Ilan Davies
, Nissar Karim
, Amira Eltokhy
, Lynn Carr
, Chris Hancock
, Cristiano Palego
, Emre C. Durmaz
, Canan Baristiran Kaynak
, Mehmet Kaynak
, Arnaud Pothier
, Delia Arnaud-Cosmos
, Philippe Leveque

School of Computer Science & Engineering

IHP Microelectronics
University of Limoges

Research output: Contribution to conference › Paper › peer-review

Abstract

The SUMCASTEC project aims to isolate and neutralize
brain cancer stem-like cells (CSC) using electromagnetic
stimulation [1]. We present a new compact nanosecond
pulse electric field generator that can deliver 500 V, 10 ns
bipolar pulses that was developed in the frame of the
project. The generator is optimized for driving
miniaturized lab-on-chip (LOC) applicators thus
supporting modulation of cell response, with relatively
lower input voltage, and higher field uniformity than in
conventional dish-based or cuvette applicators. The
preliminary experimental results demonstrate modulation
of CSCs response to nanosecond pulses through field
reversal are presented.

Original language	English
Publication status	Published - 28 Aug 2021
Event	URSI GASS 2021 - Rome, Italy Duration: 28 Aug 2021 → 4 Sept 2021

Conference

Conference	URSI GASS 2021
Country/Territory	Italy
City	Rome
Period	28/08/21 → 4/09/21

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

High Voltage Nanosecond Pulsed Electric Field (nsPEF) Electroporation Systems
Davies, I. (Author), Hancock, C. (Supervisor) & Palego, C. (Supervisor), 20 Mar 2023
Student thesis: Doctor of Philosophy

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Cite this

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title = "Compact Nanosecond Bipolar Pulse Generator for On-chip Modulation of Biological Response",

abstract = "The SUMCASTEC project aims to isolate and neutralize brain cancer stem-like cells (CSC) using electromagnetic stimulation [1]. We present a new compact nanosecond pulse electric field generator that can deliver 500 V, 10 ns bipolar pulses that was developed in the frame of the project. The generator is optimized for driving miniaturized lab-on-chip (LOC) applicators thus supporting modulation of cell response, with relatively lower input voltage, and higher field uniformity than in conventional dish-based or cuvette applicators. The preliminary experimental results demonstrate modulation of CSCs response to nanosecond pulses through field reversal are presented.",

author = "Ilan Davies and Nissar Karim and Amira Eltokhy and Lynn Carr and Chris Hancock and Cristiano Palego and Durmaz, \{Emre C.\} and Kaynak, \{Canan Baristiran\} and Mehmet Kaynak and Arnaud Pothier and Delia Arnaud-Cosmos and Philippe Leveque",

year = "2021",

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day = "28",

language = "English",

note = "URSI GASS 2021 ; Conference date: 28-08-2021 Through 04-09-2021",

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TY - CONF

T1 - Compact Nanosecond Bipolar Pulse Generator for On-chip Modulation of Biological Response

AU - Davies, Ilan

AU - Karim, Nissar

AU - Eltokhy, Amira

AU - Carr, Lynn

AU - Hancock, Chris

AU - Palego, Cristiano

AU - Durmaz, Emre C.

AU - Kaynak, Canan Baristiran

AU - Kaynak, Mehmet

AU - Pothier, Arnaud

AU - Arnaud-Cosmos, Delia

AU - Leveque, Philippe

PY - 2021/8/28

Y1 - 2021/8/28

N2 - The SUMCASTEC project aims to isolate and neutralize brain cancer stem-like cells (CSC) using electromagnetic stimulation [1]. We present a new compact nanosecond pulse electric field generator that can deliver 500 V, 10 ns bipolar pulses that was developed in the frame of the project. The generator is optimized for driving miniaturized lab-on-chip (LOC) applicators thus supporting modulation of cell response, with relatively lower input voltage, and higher field uniformity than in conventional dish-based or cuvette applicators. The preliminary experimental results demonstrate modulation of CSCs response to nanosecond pulses through field reversal are presented.

AB - The SUMCASTEC project aims to isolate and neutralize brain cancer stem-like cells (CSC) using electromagnetic stimulation [1]. We present a new compact nanosecond pulse electric field generator that can deliver 500 V, 10 ns bipolar pulses that was developed in the frame of the project. The generator is optimized for driving miniaturized lab-on-chip (LOC) applicators thus supporting modulation of cell response, with relatively lower input voltage, and higher field uniformity than in conventional dish-based or cuvette applicators. The preliminary experimental results demonstrate modulation of CSCs response to nanosecond pulses through field reversal are presented.

M3 - Paper

T2 - URSI GASS 2021

Y2 - 28 August 2021 through 4 September 2021

ER -

Compact Nanosecond Bipolar Pulse Generator for On-chip Modulation of Biological Response

Abstract

Conference

UN SDGs

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Student theses

High Voltage Nanosecond Pulsed Electric Field (nsPEF) Electroporation Systems

Cite this