Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

Paul G Mullins; David J McGonigle; Ruth L O'Gorman; Nicolaas A J Puts; Rishma Vidyasagar; C John Evans; Richard A E Edden; Cardiff Symposium on MRS of GABA

doi:10.1016/j.neuroimage.2012.12.004

Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

Paul G Mullins
, David J McGonigle
, Ruth L O'Gorman
, Nicolaas A J Puts
, Rishma Vidyasagar
, C John Evans
, Richard A E Edden
, Cardiff Symposium on MRS of GABA

Cardiff University
University Children's Hospital, Zurich
University of Zürich
Johns Hopkins University
Kennedy Krieger Institute
Manchester University

Research output: Contribution to journal › Article › peer-review

Abstract

There is increasing interest in the use of edited proton magnetic resonance spectroscopy for the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a number of spectroscopy groups met to discuss the acquisition, analysis and interpretation of GABA-edited MR spectra. This paper aims to set out the issues discussed at this meeting, reporting areas of consensus around parameters and procedures in the field and highlighting those areas where differences remain. It is hoped that this paper can fulfill two needs, providing a summary of the current ‘state-of-the-art’ in the field of GABA-edited MRS at 3 T using MEGA-PRESS and a basic guide to help researchers new to the field to avoid some of the pitfalls inherent in the acquisition and processing of edited MRS for GABA.

Original language	English
Pages (from-to)	43-52
Number of pages	10
Journal	Neuroimage
Volume	86
Early online date	13 Dec 2012
DOIs	https://doi.org/10.1016/j.neuroimage.2012.12.004
Publication status	Published - 1 Feb 2014

Keywords

Algorithms
Brain
Humans
Magnetic Resonance Spectroscopy
Reproducibility of Results
Sensitivity and Specificity
gamma-Aminobutyric Acid
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Access to Document

10.1016/j.neuroimage.2012.12.004

Editing School
Mullins, P. (Speaker)
3 Dec 2018 → 6 Dec 2018
Activity: Participating in or organising an event › Participation in Academic conference

Bangor Imaging UNit - 3 T MRI scanner
Mullins, P. (Manager), Binney, R. (Other), Bestelmeyer, P. (Other), Downing, P. (Other), Kornysheva, E. (Other), Valyear, K. (Other), Koldewyn, K. (Other), Ramsey, R. (Other), d'Avossa, G. (Other), Carey, D. (Other), Henderson, R. (Other), Rossetti, G. (Other), Oliver, S. (Other) & Macdonald, J. (Other)
Facility/equipment: Facility

Cite this

@article{64bb031a87a94cf0ab7776ddb79268cd,

title = "Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA",

abstract = "There is increasing interest in the use of edited proton magnetic resonance spectroscopy for the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a number of spectroscopy groups met to discuss the acquisition, analysis and interpretation of GABA-edited MR spectra. This paper aims to set out the issues discussed at this meeting, reporting areas of consensus around parameters and procedures in the field and highlighting those areas where differences remain. It is hoped that this paper can fulfill two needs, providing a summary of the current {\textquoteleft}state-of-the-art{\textquoteright} in the field of GABA-edited MRS at 3 T using MEGA-PRESS and a basic guide to help researchers new to the field to avoid some of the pitfalls inherent in the acquisition and processing of edited MRS for GABA.",

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author = "Mullins, \{Paul G\} and McGonigle, \{David J\} and O'Gorman, \{Ruth L\} and Puts, \{Nicolaas A J\} and Rishma Vidyasagar and Evans, \{C John\} and Edden, \{Richard A E\} and \{Cardiff Symposium on MRS of GABA\}",

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doi = "10.1016/j.neuroimage.2012.12.004",

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AU - Mullins, Paul G

AU - McGonigle, David J

AU - O'Gorman, Ruth L

AU - Puts, Nicolaas A J

AU - Vidyasagar, Rishma

AU - Evans, C John

AU - Edden, Richard A E

AU - Cardiff Symposium on MRS of GABA

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AB - There is increasing interest in the use of edited proton magnetic resonance spectroscopy for the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a number of spectroscopy groups met to discuss the acquisition, analysis and interpretation of GABA-edited MR spectra. This paper aims to set out the issues discussed at this meeting, reporting areas of consensus around parameters and procedures in the field and highlighting those areas where differences remain. It is hoped that this paper can fulfill two needs, providing a summary of the current ‘state-of-the-art’ in the field of GABA-edited MRS at 3 T using MEGA-PRESS and a basic guide to help researchers new to the field to avoid some of the pitfalls inherent in the acquisition and processing of edited MRS for GABA.

KW - Algorithms

KW - Brain

KW - Humans

KW - Magnetic Resonance Spectroscopy

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - gamma-Aminobutyric Acid

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Review

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SN - 1053-8119

VL - 86

SP - 43

EP - 52

JO - Neuroimage

JF - Neuroimage

ER -

Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

Abstract

Keywords

Access to Document

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Activities

Editing School

Equipment

Bangor Imaging UNit - 3 T MRI scanner

Cite this