Fast, compact and label-free electrical detection of live and dead single cells

Y. Ning; C.R. Multari; X. Luo; C. Merla; C. Palego; X. Cheng; J.C. Hwang

doi:10.1109/IMWS-BIO.2013.6756250

Fast, compact and label-free electrical detection of live and dead single cells

Y. Ning, C.R. Multari, X. Luo, C. Merla, C. Palego, X. Cheng, J.C. Hwang

Research output: Contribution to conference › Paper

Abstract

Using a novel broadband microchamber, electrical detection of live and dead single cells was demonstrated. Tests on Jurkat cells showed that live cells had lower resistance but higher capacitance than that of dead cells. The test results were compared with the limited literature on broadband electrical detection of single cells and the discrepancies, both qualitative and quantitative, were discussed. These results indicate that, while broadband electrical detection at the single-cell level is becoming feasible, many challenges remain in impedance match, calibration, sensitivity, cell manipulation, solution effect and modeling.

Original language	English
DOIs	https://doi.org/10.1109/IMWS-BIO.2013.6756250
Publication status	Published - 9 Dec 2013
Event	Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013 IEEE MTT-S International, Singapore - Duration: 3 Jan 0001 → …

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Conference	Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013 IEEE MTT-S International, Singapore
Period	3/01/01 → …

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Ning, Y., Multari, C. R., Luo, X., Merla, C., Palego, C., Cheng, X., & Hwang, J. C. (2013). Fast, compact and label-free electrical detection of live and dead single cells. Paper presented at Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013 IEEE MTT-S International, Singapore. https://doi.org/10.1109/IMWS-BIO.2013.6756250

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Ning, Y, Multari, CR, Luo, X, Merla, C, Palego, C, Cheng, X & Hwang, JC 2013, 'Fast, compact and label-free electrical detection of live and dead single cells', Paper presented at Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013 IEEE MTT-S International, Singapore, 3/01/01. https://doi.org/10.1109/IMWS-BIO.2013.6756250

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T1 - Fast, compact and label-free electrical detection of live and dead single cells

AU - Ning, Y.

AU - Multari, C.R.

AU - Luo, X.

AU - Merla, C.

AU - Palego, C.

AU - Cheng, X.

AU - Hwang, J.C.

PY - 2013/12/9

Y1 - 2013/12/9

N2 - Using a novel broadband microchamber, electrical detection of live and dead single cells was demonstrated. Tests on Jurkat cells showed that live cells had lower resistance but higher capacitance than that of dead cells. The test results were compared with the limited literature on broadband electrical detection of single cells and the discrepancies, both qualitative and quantitative, were discussed. These results indicate that, while broadband electrical detection at the single-cell level is becoming feasible, many challenges remain in impedance match, calibration, sensitivity, cell manipulation, solution effect and modeling.

AB - Using a novel broadband microchamber, electrical detection of live and dead single cells was demonstrated. Tests on Jurkat cells showed that live cells had lower resistance but higher capacitance than that of dead cells. The test results were compared with the limited literature on broadband electrical detection of single cells and the discrepancies, both qualitative and quantitative, were discussed. These results indicate that, while broadband electrical detection at the single-cell level is becoming feasible, many challenges remain in impedance match, calibration, sensitivity, cell manipulation, solution effect and modeling.

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DO - 10.1109/IMWS-BIO.2013.6756250

M3 - Paper

T2 - Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013 IEEE MTT-S International, Singapore

Y2 - 3 January 0001

ER -

Fast, compact and label-free electrical detection of live and dead single cells

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