Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation

Emma Bedson; Diana Bell; Daniel Carr; Ben Carter; Dyfrig Hughes; Andrea Jorgensen; Helen Lewis; Keith Lloyd; Andrew McCaddon; Stuart Moat; Joshua Pink; Munir Pirmohamed; Seren Roberts; Ian Russell; Yvonne Sylvestre; Richard Tranter; Rhiannon Whitaker; Clare Wilkinson; Nefyn Williams

doi:10.3310/hta18480

Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation

Emma Bedson
, Diana Bell
, Daniel Carr
, Ben Carter
, Dyfrig Hughes
, Andrea Jorgensen
, Helen Lewis
, Keith Lloyd
, Andrew McCaddon
, Stuart Moat
, Joshua Pink
, Munir Pirmohamed
, Seren Roberts
, Ian Russell
, Yvonne Sylvestre
, Richard Tranter
, Rhiannon Whitaker
, Clare Wilkinson
, Nefyn Williams

The North Wales School of Education

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract Background Folate deficiency is associated with depression. Despite the biological plausibility of a causal link, the evidence that adding folate enhances antidepressant treatment is weak. Objectives (1) Estimate the clinical effectiveness and cost-effectiveness of folic acid as adjunct to antidepressant medication (ADM). (2) Explore whether baseline folate and homocysteine predict response to treatment. (3) Investigate whether response to treatment depends on genetic polymorphisms related to folate metabolism.

Original language	English
Pages (from-to)	1-159
Journal	Health Technology Assessment
Volume	18
Issue number	48
DOIs	https://doi.org/10.3310/hta18480
Publication status	Published - Jul 2014

Keywords

Adult
Antidepressive Agents
Cost-Benefit Analysis
Depression
Female
Folic Acid
Humans
Male
Polymorphism, Genetic
Risk Factors
Treatment Outcome
Wales
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

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10.3310/hta18480

Cite this

Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., Lewis, H., Lloyd, K., McCaddon, A., Moat, S., Pink, J., Pirmohamed, M., Roberts, S., Russell, I., Sylvestre, Y., Tranter, R., Whitaker, R., Wilkinson, C., & Williams, N. (2014). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation. Health Technology Assessment, 18(48), 1-159. https://doi.org/10.3310/hta18480

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title = "Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation",

abstract = "Abstract Background Folate deficiency is associated with depression. Despite the biological plausibility of a causal link, the evidence that adding folate enhances antidepressant treatment is weak. Objectives (1) Estimate the clinical effectiveness and cost-effectiveness of folic acid as adjunct to antidepressant medication (ADM). (2) Explore whether baseline folate and homocysteine predict response to treatment. (3) Investigate whether response to treatment depends on genetic polymorphisms related to folate metabolism.",

keywords = "Adult, Antidepressive Agents, Cost-Benefit Analysis, Depression, Female, Folic Acid, Humans, Male, Polymorphism, Genetic, Risk Factors, Treatment Outcome, Wales, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",

author = "Emma Bedson and Diana Bell and Daniel Carr and Ben Carter and Dyfrig Hughes and Andrea Jorgensen and Helen Lewis and Keith Lloyd and Andrew McCaddon and Stuart Moat and Joshua Pink and Munir Pirmohamed and Seren Roberts and Ian Russell and Yvonne Sylvestre and Richard Tranter and Rhiannon Whitaker and Clare Wilkinson and Nefyn Williams",

year = "2014",

month = jul,

doi = "10.3310/hta18480",

language = "English",

volume = "18",

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journal = "Health Technology Assessment",

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Bedson, E, Bell, D, Carr, D, Carter, B, Hughes, D, Jorgensen, A, Lewis, H, Lloyd, K, McCaddon, A, Moat, S, Pink, J, Pirmohamed, M, Roberts, S, Russell, I, Sylvestre, Y, Tranter, R, Whitaker, R, Wilkinson, C & Williams, N 2014, 'Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation', Health Technology Assessment, vol. 18, no. 48, pp. 1-159. https://doi.org/10.3310/hta18480

TY - JOUR

T1 - Folate Augmentation of Treatment-Evaluation for Depression (FolATED)

T2 - randomised trial and economic evaluation

AU - Bedson, Emma

AU - Bell, Diana

AU - Carr, Daniel

AU - Carter, Ben

AU - Hughes, Dyfrig

AU - Jorgensen, Andrea

AU - Lewis, Helen

AU - Lloyd, Keith

AU - McCaddon, Andrew

AU - Moat, Stuart

AU - Pink, Joshua

AU - Pirmohamed, Munir

AU - Roberts, Seren

AU - Russell, Ian

AU - Sylvestre, Yvonne

AU - Tranter, Richard

AU - Whitaker, Rhiannon

AU - Wilkinson, Clare

AU - Williams, Nefyn

PY - 2014/7

Y1 - 2014/7

N2 - Abstract Background Folate deficiency is associated with depression. Despite the biological plausibility of a causal link, the evidence that adding folate enhances antidepressant treatment is weak. Objectives (1) Estimate the clinical effectiveness and cost-effectiveness of folic acid as adjunct to antidepressant medication (ADM). (2) Explore whether baseline folate and homocysteine predict response to treatment. (3) Investigate whether response to treatment depends on genetic polymorphisms related to folate metabolism.

AB - Abstract Background Folate deficiency is associated with depression. Despite the biological plausibility of a causal link, the evidence that adding folate enhances antidepressant treatment is weak. Objectives (1) Estimate the clinical effectiveness and cost-effectiveness of folic acid as adjunct to antidepressant medication (ADM). (2) Explore whether baseline folate and homocysteine predict response to treatment. (3) Investigate whether response to treatment depends on genetic polymorphisms related to folate metabolism.

KW - Adult

KW - Antidepressive Agents

KW - Cost-Benefit Analysis

KW - Depression

KW - Female

KW - Folic Acid

KW - Humans

KW - Male

KW - Polymorphism, Genetic

KW - Risk Factors

KW - Treatment Outcome

KW - Wales

KW - Journal Article

KW - Multicenter Study

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.3310/hta18480

DO - 10.3310/hta18480

M3 - Article

C2 - 25052890

SN - 1366-5278

VL - 18

SP - 1

EP - 159

JO - Health Technology Assessment

JF - Health Technology Assessment

IS - 48

ER -

Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation

Abstract

Keywords

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