Improved broadband electrical detection of individual biological cells

Y. Ning; X. Ma; C. Multari; X. Luo; V. Gholizadeb; C. Palego; X. Cheng; J. Hwang

doi:10.1109/MWSYM.2015.7166722

Improved broadband electrical detection of individual biological cells

Y. Ning, X. Ma, C. Multari, X. Luo, V. Gholizadeb, C. Palego, X. Cheng, J. Hwang

Research output: Contribution to conference › Paper

Abstract

Based on a homemade probe station on top of an inverted microscope for simultaneous microwave measurement and visual validation, broadband detection of live Jurkat cells was successfully extended from 2-3.5 GHz to 0.5-20 GHz with comparable sensitivity and reproducibility. With a carefully optimized coplanar waveguide, closely spaced microwave probes, and frequent calibrations, reference planes were established next to the microfluidic channel, which resulted in smooth and well-behaved scattering parameters without spurious resonances. From the measured scattering parameters, the extracted cytoplasm resistance of 190 kΩ was consistent with the previously reported value but validated over a much wider bandwidth.

Original language	English
Pages	1-3
DOIs	https://doi.org/10.1109/MWSYM.2015.7166722
Publication status	Published - 17 May 2015
Event	IEEE International Microwave Symposium, Phoenix, USA, May 2015 - Duration: 3 Jan 0001 → …

Conference

Conference	IEEE International Microwave Symposium, Phoenix, USA, May 2015
Period	3/01/01 → …

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10.1109/MWSYM.2015.7166722

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abstract = "Based on a homemade probe station on top of an inverted microscope for simultaneous microwave measurement and visual validation, broadband detection of live Jurkat cells was successfully extended from 2-3.5 GHz to 0.5-20 GHz with comparable sensitivity and reproducibility. With a carefully optimized coplanar waveguide, closely spaced microwave probes, and frequent calibrations, reference planes were established next to the microfluidic channel, which resulted in smooth and well-behaved scattering parameters without spurious resonances. From the measured scattering parameters, the extracted cytoplasm resistance of 190 kΩ was consistent with the previously reported value but validated over a much wider bandwidth.",

author = "Y. Ning and X. Ma and C. Multari and X. Luo and V. Gholizadeb and C. Palego and X. Cheng and J. Hwang",

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AU - Ning, Y.

AU - Ma, X.

AU - Multari, C.

AU - Luo, X.

AU - Gholizadeb, V.

AU - Palego, C.

AU - Cheng, X.

AU - Hwang, J.

PY - 2015/5/17

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N2 - Based on a homemade probe station on top of an inverted microscope for simultaneous microwave measurement and visual validation, broadband detection of live Jurkat cells was successfully extended from 2-3.5 GHz to 0.5-20 GHz with comparable sensitivity and reproducibility. With a carefully optimized coplanar waveguide, closely spaced microwave probes, and frequent calibrations, reference planes were established next to the microfluidic channel, which resulted in smooth and well-behaved scattering parameters without spurious resonances. From the measured scattering parameters, the extracted cytoplasm resistance of 190 kΩ was consistent with the previously reported value but validated over a much wider bandwidth.

AB - Based on a homemade probe station on top of an inverted microscope for simultaneous microwave measurement and visual validation, broadband detection of live Jurkat cells was successfully extended from 2-3.5 GHz to 0.5-20 GHz with comparable sensitivity and reproducibility. With a carefully optimized coplanar waveguide, closely spaced microwave probes, and frequent calibrations, reference planes were established next to the microfluidic channel, which resulted in smooth and well-behaved scattering parameters without spurious resonances. From the measured scattering parameters, the extracted cytoplasm resistance of 190 kΩ was consistent with the previously reported value but validated over a much wider bandwidth.

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T2 - IEEE International Microwave Symposium, Phoenix, USA, May 2015

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ER -

Improved broadband electrical detection of individual biological cells

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