Integrative crosstalk between hypoxia and the cold: old data and new opportunities

Hendrik Mugele, Sam Oliver, Daniel Gagnon, Justin Lawley

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    Abstract

    Cold stress and hypoxia have been the subject of research for decades; however, humans often encounter these stressors together, such as in the alpine environment. Therefore, this review summarizes previous data with respect to the influence of hypoxia on thermoregulatory and cardiovascular control in the cold and presents new ideas for the future. Altogether, little to no evidence is available on the integrative and adaptive mechanisms about how the human body regulates heat conservation, oxygen delivery, and maintenance of blood pressure.
    Original languageEnglish
    Pages (from-to)350-358
    JournalExperimental Physiology
    Volume106
    Issue number1
    Early online date30 Jun 2020
    DOIs
    Publication statusPublished - 1 Jan 2021

    Keywords

    • cardiovascular physiology
    • cold and hypoxia
    • cutaneous vasoconstriction
    • thermogenesis

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