Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma

David J. Duffy; Aleksandar Krstic; Melinda Halasz; Thomas Schwarzl; Dirk Fey; Kristiina Iljin; Jai Prakash Mehta; Kate Killick; Jenny Whilde; Benedetta Turriziani; Saija Haapa-Paananen; Vidal Fey; Matthias Fischer; Frank Westermann; Kai-Oliver Henrich; Steffen Bannert; Desmond G. Higgins; Walter Kolch

Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma

David J. Duffy, Aleksandar Krstic, Melinda Halasz, Thomas Schwarzl, Dirk Fey, Kristiina Iljin, Jai Prakash Mehta, Kate Killick, Jenny Whilde, Benedetta Turriziani, Saija Haapa-Paananen, Vidal Fey, Matthias Fischer, Frank Westermann, Kai-Oliver Henrich, Steffen Bannert, Desmond G. Higgins, Walter Kolch

University College Dublin

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	43182-43201
Journal	Oncotarget
Volume	6
Issue number	41
Publication status	Published - 22 Dec 2015
Externally published	Yes

Keywords

MYC (c-MYC)
neuroblastoma
transcriptional regulation
mRNA sequencing (mRNA-seq)
4sU-seq

Cite this

Duffy, D. J., Krstic, A., Halasz, M., Schwarzl, T., Fey, D., Iljin, K., Mehta, J. P., Killick, K., Whilde, J., Turriziani, B., Haapa-Paananen, S., Fey, V., Fischer, M., Westermann, F., Henrich, K.-O., Bannert, S., Higgins, D. G., & Kolch, W. (2015). Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma. Oncotarget, 6(41), 43182-43201.

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title = "Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma",

keywords = "MYC (c-MYC), neuroblastoma, transcriptional regulation, mRNA sequencing (mRNA-seq), 4sU-seq",

author = "Duffy, \{David J.\} and Aleksandar Krstic and Melinda Halasz and Thomas Schwarzl and Dirk Fey and Kristiina Iljin and Mehta, \{Jai Prakash\} and Kate Killick and Jenny Whilde and Benedetta Turriziani and Saija Haapa-Paananen and Vidal Fey and Matthias Fischer and Frank Westermann and Kai-Oliver Henrich and Steffen Bannert and Higgins, \{Desmond G.\} and Walter Kolch",

year = "2015",

month = dec,

day = "22",

language = "English",

volume = "6",

pages = "43182--43201",

journal = "Oncotarget",

issn = "1949-2553",

publisher = "Impact Journals",

number = "41",

}

Duffy, DJ, Krstic, A, Halasz, M, Schwarzl, T, Fey, D, Iljin, K, Mehta, JP, Killick, K, Whilde, J, Turriziani, B, Haapa-Paananen, S, Fey, V, Fischer, M, Westermann, F, Henrich, K-O, Bannert, S, Higgins, DG & Kolch, W 2015, 'Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma', Oncotarget, vol. 6, no. 41, pp. 43182-43201.

TY - JOUR

T1 - Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma

AU - Duffy, David J.

AU - Krstic, Aleksandar

AU - Halasz, Melinda

AU - Schwarzl, Thomas

AU - Fey, Dirk

AU - Iljin, Kristiina

AU - Mehta, Jai Prakash

AU - Killick, Kate

AU - Whilde, Jenny

AU - Turriziani, Benedetta

AU - Haapa-Paananen, Saija

AU - Fey, Vidal

AU - Fischer, Matthias

AU - Westermann, Frank

AU - Henrich, Kai-Oliver

AU - Bannert, Steffen

AU - Higgins, Desmond G.

AU - Kolch, Walter

PY - 2015/12/22

Y1 - 2015/12/22

KW - MYC (c-MYC)

KW - neuroblastoma

KW - transcriptional regulation

KW - mRNA sequencing (mRNA-seq)

KW - 4sU-seq

M3 - Article

SN - 1949-2553

VL - 6

SP - 43182

EP - 43201

JO - Oncotarget

JF - Oncotarget

IS - 41

ER -