TY - JOUR
T1 - Meta-analysis of cancer microarray data sets reveals a germ line expression profile in ovarian cancers: new biomarkers and potential drug targets
AU - Mcfarlane, R.J.
AU - McFarlane, R.
PY - 2015/8/15
Y1 - 2015/8/15
N2 - One of the main challenges facing oncology is the identification of highly restricted, cancer-specific biomarkers for use in early diagnostics, prognostics, patient stratification and as potential therapeutic targets, including immunotherapeutic and small drug targets. Germ line genes are normally only expressed in the reproductive organs and meiosis-specific genes are normally only activated within the foetal oocytes and/or the spermatocytes in adult males. Our work has been based on the hypothesis that these germ line genes become activated in cancers, driving the oncogenic process and serving as clinically relevant biomarkers / targets.
AB - One of the main challenges facing oncology is the identification of highly restricted, cancer-specific biomarkers for use in early diagnostics, prognostics, patient stratification and as potential therapeutic targets, including immunotherapeutic and small drug targets. Germ line genes are normally only expressed in the reproductive organs and meiosis-specific genes are normally only activated within the foetal oocytes and/or the spermatocytes in adult males. Our work has been based on the hypothesis that these germ line genes become activated in cancers, driving the oncogenic process and serving as clinically relevant biomarkers / targets.
U2 - 10.1158/1557-3265.OVCASYMP14-POSTER-TECH-1118
DO - 10.1158/1557-3265.OVCASYMP14-POSTER-TECH-1118
M3 - Article
SN - 1078-0432
VL - 21
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 16
ER -
