TY - JOUR
T1 - Navigating Zoonotic Landscapes: From Genomic Insights to Ethical Frontiers
AU - Aljabali, Alaa A A
AU - Alqudah, Abdelrahim
AU - Bashatwah, Rasha M.
AU - Alsharedeh, Rawan
AU - Qnais, Esam
AU - Gammoh, Omar
AU - Mishra, Vijay
AU - Mishra, Yachana
AU - El-Tanani, Mohamed
AU - Hatahet, Taher
PY - 2025/11/13
Y1 - 2025/11/13
N2 - Viral zoonoses represent a critical intersection of global health, ecology, and ethical issues. Pathogens that pass from animals to humans. This review examines the complex landscape of viral zoonoses, including their mechanisms, impact, and mitigation strategies. We begin with insights into the historical context and significance of these diseases and then explore spillover mechanisms influenced by genetic, ecological, and anthropogenic factors. This review covers the host range, transmission dynamics, and immunological barriers, including viral detection, adaptation, and immune evasion. Genomic insights have revealed the genetic determinants of host switching and adaptation, illuminating the dynamics of viral spillover events. We emphasize the anticipation and prevention of zoonotic events, highlighting surveillance, early warning systems, and the “One Health” approach. Using case studies of outbreaks such as Ebola, avian influenza, and COVID-19, this review examines the real-world consequences of zoonotic diseases. We then discuss interventions, including mitigation strategies and vaccination, and their ethical and social implications. Drawing on past outbreaks, we provide recommendations for the future, aiming to balance human health, conservation, and animal welfare. This review aims to inform professionals, academics, and policymakers by offering a multidisciplinary perspective on the complex world of viral zoonoses and strategies to protect global health.
AB - Viral zoonoses represent a critical intersection of global health, ecology, and ethical issues. Pathogens that pass from animals to humans. This review examines the complex landscape of viral zoonoses, including their mechanisms, impact, and mitigation strategies. We begin with insights into the historical context and significance of these diseases and then explore spillover mechanisms influenced by genetic, ecological, and anthropogenic factors. This review covers the host range, transmission dynamics, and immunological barriers, including viral detection, adaptation, and immune evasion. Genomic insights have revealed the genetic determinants of host switching and adaptation, illuminating the dynamics of viral spillover events. We emphasize the anticipation and prevention of zoonotic events, highlighting surveillance, early warning systems, and the “One Health” approach. Using case studies of outbreaks such as Ebola, avian influenza, and COVID-19, this review examines the real-world consequences of zoonotic diseases. We then discuss interventions, including mitigation strategies and vaccination, and their ethical and social implications. Drawing on past outbreaks, we provide recommendations for the future, aiming to balance human health, conservation, and animal welfare. This review aims to inform professionals, academics, and policymakers by offering a multidisciplinary perspective on the complex world of viral zoonoses and strategies to protect global health.
KW - zoonotic diseases
KW - spillover mechanisms
KW - one health approach
KW - genomic in- sights
KW - pandemic preparedness
KW - ethical implications
KW - disease mitigation
U2 - 10.3390/zoonoticdis5040035
DO - 10.3390/zoonoticdis5040035
M3 - Review article
SN - 2813-0227
VL - 5
JO - Zoonotic Diseases
JF - Zoonotic Diseases
IS - 4
M1 - 35
ER -
