New insights into the genetic etiology of Alzheimer’s disease and related dementias

EADB; GR@ACE; DEGESCO; EADI; GERAD; Demgene; FinnGen; ADGC; CHARGE; Céline Bellenguez; Catherine A. MacLeod; Gill Windle; Bob Woods; Lindsay A. Farrer; Bruce M. Psaty; Mohsen Ghanbari; Towfique Raj; Perminder  Sachdev; Karen Mather; Frank Jessen; M. Arfan Ikram; Alexandre de Mendonça; Jakub Hort; Magda Tsolaki; Margaret A. Pericak-Vance; Philippe Amouyel; Julie Williams; Ruth Frikke-Schmidt; Jordi Clarimón; Jean-François Deleuze; Giacomina Rossi; Sudha Seshadri; Ole A. Andreassen; Martin Ingelsson; Mikko Hiltunen; Kristel Sleegers; Gerard D. Schellenberg; Cornelia M. van Duijn; Rebecca Sims; Wiesje M. van der Flier; Agustín Ruiz; Alfredo Ramirez; Jean-Charles Lambert

doi:10.1038/s41588-022-01024-z

New insights into the genetic etiology of Alzheimer’s disease and related dementias

EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE, Céline Bellenguez, Catherine A. MacLeod, Gill Windle, Bob Woods, Lindsay A. Farrer, Bruce M. Psaty, Mohsen Ghanbari, Towfique Raj, Perminder Sachdev, Karen Mather, Frank JessenM. Arfan Ikram, Alexandre de Mendonça, Jakub Hort, Magda Tsolaki, Margaret A. Pericak-Vance, Philippe Amouyel, Julie Williams, Ruth Frikke-Schmidt, Jordi Clarimón, Jean-François Deleuze, Giacomina Rossi, Sudha Seshadri, Ole A. Andreassen, Martin Ingelsson, Mikko Hiltunen, Kristel Sleegers, Gerard D. Schellenberg, Cornelia M. van Duijn, Rebecca Sims, Wiesje M. van der Flier, Agustín Ruiz, Alfredo Ramirez, Jean-Charles Lambert

School of Health Sciences

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Original language	English
Pages (from-to)	412-436
Number of pages	25
Journal	Nature Genetics
Volume	54
Issue number	4
Early online date	4 Apr 2022
DOIs	https://doi.org/10.1038/s41588-022-01024-z
Publication status	Published - Apr 2022

Keywords

Alzheimer's disease
Genome-Wide Association Study

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10.1038/s41588-022-01024-zLicence: CC BY

s41588-022-01024-zFinal published version, 4.92 MBLicence: CC BY

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EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE, Bellenguez, C., MacLeod, C. A., Windle, G., Woods, B., Farrer, L. A., Psaty, B. M., Ghanbari, M., Raj, T., Sachdev, P., Mather, K., ... Lambert, J.-C. (2022). New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nature Genetics, 54(4), 412-436. https://doi.org/10.1038/s41588-022-01024-z

@article{2f01cf6ee40d4d2f9d781aa7b1ee0042,

title = "New insights into the genetic etiology of Alzheimer{\textquoteright}s disease and related dementias",

keywords = "Alzheimer's disease, Genome-Wide Association Study",

author = "EADB and GR@ACE and DEGESCO and EADI and GERAD and Demgene and FinnGen and ADGC and CHARGE and C{\'e}line Bellenguez and Fahri K{\"u}{\c c}{\"u}kali and Jansen, \{Iris E.\} and Luca Kleineidam and Sonia Moreno-Grau and Najaf Amin and Naj, \{Adam C.\} and Rafael Campos-Martin and Benjamin Grenier-Boley and Victor Andrade and Holmans, \{Peter A.\} and Anne Boland and Vincent Damotte and \{van der Lee\}, \{Sven J.\} and Costa, \{Marcos R.\} and Teemu Kuulasmaa and Qiong Yang and \{de Rojas\}, Itziar and Bis, \{Joshua C.\} and Amber Yaqub and Ivana Prokic and Julien Chapuis and Shahzad Ahmad and Vilmantas Giedraitis and Dag Aarsland and Pablo Garcia-Gonzalez and Carla Abdelnour and Emilio Alarc{\'o}n-Mart{\'i}n and Daniel Alcolea and Montserrat Alegret and Ignacio Alvarez and Victoria {\'A}lvarez and Armstrong, \{Nicola J.\} and Anthoula Tsolaki and Carmen Ant{\'u}nez and Ildebrando Appollonio and Marina Arcaro and Silvana Archetti and Pastor, \{Alfonso Arias\} and Beatrice Arosio and Lavinia Athanasiu and Henri Bailly and Nerisa Banaj and Miquel Baquero and Sandra Barral and Alexa Beiser and Pastor, \{Ana Bel{\'e}n\} and MacLeod, \{Catherine A.\} and Gill Windle and Bob Woods and Farrer, \{Lindsay A.\} and Psaty, \{Bruce M.\} and Mohsen Ghanbari and Towfique Raj and Perminder Sachdev and Karen Mather and Frank Jessen and Ikram, \{M. Arfan\} and \{de Mendon{\c c}a\}, Alexandre and Jakub Hort and Magda Tsolaki and Pericak-Vance, \{Margaret A.\} and Philippe Amouyel and Julie Williams and Ruth Frikke-Schmidt and Jordi Clarim{\'o}n and Jean-Fran{\c c}ois Deleuze and Giacomina Rossi and Sudha Seshadri and Andreassen, \{Ole A.\} and Martin Ingelsson and Mikko Hiltunen and Kristel Sleegers and Schellenberg, \{Gerard D.\} and \{van Duijn\}, \{Cornelia M.\} and Rebecca Sims and \{van der Flier\}, \{Wiesje M.\} and Agust{\'i}n Ruiz and Alfredo Ramirez and Jean-Charles Lambert",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

month = apr,

doi = "10.1038/s41588-022-01024-z",

language = "English",

volume = "54",

pages = "412--436",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Research",

number = "4",

}

EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE, Bellenguez, C, MacLeod, CA, Windle, G , Woods, B, Farrer, LA, Psaty, BM, Ghanbari, M, Raj, T, Sachdev, P, Mather, K, Jessen, F, Ikram, MA, de Mendonça, A, Hort, J, Tsolaki, M, Pericak-Vance, MA, Amouyel, P, Williams, J, Frikke-Schmidt, R, Clarimón, J, Deleuze, J-F, Rossi, G, Seshadri, S, Andreassen, OA, Ingelsson, M, Hiltunen, M, Sleegers, K, Schellenberg, GD, van Duijn, CM, Sims, R, van der Flier, WM, Ruiz, A, Ramirez, A & Lambert, J-C 2022, 'New insights into the genetic etiology of Alzheimer’s disease and related dementias', Nature Genetics, vol. 54, no. 4, pp. 412-436. https://doi.org/10.1038/s41588-022-01024-z

TY - JOUR

T1 - New insights into the genetic etiology of Alzheimer’s disease and related dementias

AU - EADB

AU - GR@ACE

AU - DEGESCO

AU - EADI

AU - GERAD

AU - Demgene

AU - FinnGen

AU - ADGC

AU - CHARGE

AU - Bellenguez, Céline

AU - Küçükali, Fahri

AU - Jansen, Iris E.

AU - Kleineidam, Luca

AU - Moreno-Grau, Sonia

AU - Amin, Najaf

AU - Naj, Adam C.

AU - Campos-Martin, Rafael

AU - Grenier-Boley, Benjamin

AU - Andrade, Victor

AU - Holmans, Peter A.

AU - Boland, Anne

AU - Damotte, Vincent

AU - van der Lee, Sven J.

AU - Costa, Marcos R.

AU - Kuulasmaa, Teemu

AU - Yang, Qiong

AU - de Rojas, Itziar

AU - Bis, Joshua C.

AU - Yaqub, Amber

AU - Prokic, Ivana

AU - Chapuis, Julien

AU - Ahmad, Shahzad

AU - Giedraitis, Vilmantas

AU - Aarsland, Dag

AU - Garcia-Gonzalez, Pablo

AU - Abdelnour, Carla

AU - Alarcón-Martín, Emilio

AU - Alcolea, Daniel

AU - Alegret, Montserrat

AU - Alvarez, Ignacio

AU - Álvarez, Victoria

AU - Armstrong, Nicola J.

AU - Tsolaki, Anthoula

AU - Antúnez, Carmen

AU - Appollonio, Ildebrando

AU - Arcaro, Marina

AU - Archetti, Silvana

AU - Pastor, Alfonso Arias

AU - Arosio, Beatrice

AU - Athanasiu, Lavinia

AU - Bailly, Henri

AU - Banaj, Nerisa

AU - Baquero, Miquel

AU - Barral, Sandra

AU - Beiser, Alexa

AU - Pastor, Ana Belén

AU - MacLeod, Catherine A.

AU - Windle, Gill

AU - Woods, Bob

AU - Farrer, Lindsay A.

AU - Psaty, Bruce M.

AU - Ghanbari, Mohsen

AU - Raj, Towfique

AU - Sachdev, Perminder

AU - Mather, Karen

AU - Jessen, Frank

AU - Ikram, M. Arfan

AU - de Mendonça, Alexandre

AU - Hort, Jakub

AU - Tsolaki, Magda

AU - Pericak-Vance, Margaret A.

AU - Amouyel, Philippe

AU - Williams, Julie

AU - Frikke-Schmidt, Ruth

AU - Clarimón, Jordi

AU - Deleuze, Jean-François

AU - Rossi, Giacomina

AU - Seshadri, Sudha

AU - Andreassen, Ole A.

AU - Ingelsson, Martin

AU - Hiltunen, Mikko

AU - Sleegers, Kristel

AU - Schellenberg, Gerard D.

AU - van Duijn, Cornelia M.

AU - Sims, Rebecca

AU - van der Flier, Wiesje M.

AU - Ruiz, Agustín

AU - Ramirez, Alfredo

AU - Lambert, Jean-Charles

PY - 2022/4

Y1 - 2022/4

KW - Alzheimer's disease

KW - Genome-Wide Association Study

U2 - 10.1038/s41588-022-01024-z

DO - 10.1038/s41588-022-01024-z

M3 - Article

C2 - 35379992

SN - 1546-1718

VL - 54

SP - 412

EP - 436

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Keywords

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