Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance

T Dimitroulas; A Sandoo; J J J C S Veldhuijzen van Zanten; J P Smith; J Hodson; G S Metsios; A Stavropoulos-Kalinoglou; G D Kitas

doi:10.3109/03009742.2012.747627

Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance

T Dimitroulas, A Sandoo, J J J C S Veldhuijzen van Zanten, J P Smith, J Hodson, G S Metsios, A Stavropoulos-Kalinoglou, G D Kitas

Dudley Group NHS, Dudley

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To determine whether demographic, inflammatory, and metabolic factors predict elevated asymmetric dimethylarginine (ADMA) levels in rheumatoid arthritis (RA).

METHOD: A total of 67 RA patients [mean age 56 ± 12 years, median disease duration 8 (3-15) years] were assessed. Routine biochemistry tests, lipid profile, glycaemic profile [glucose, insulin, homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI)], and inflammatory markers were measured in all patients. ADMA levels were measured by enzyme-linked immunosorbent assay (ELISA). Regression analyses were performed to identify predictors of ADMA in RA.

RESULTS: Regression analysis revealed that HOMA (β = 0.149, p = 0.003) was an independent predictor of ADMA in RA. From the drug factors, anti-hypertensive medication use was associated with lower ADMA levels (β = -0.081, p = 0.004). ADMA was not associated with RA disease-related parameters or any of the other cardiovascular risk factors that were assessed.

CONCLUSIONS: HOMA, a strong indicator of insulin resistance, seems to be the main predictor of elevated ADMA levels in RA patients; ADMA may reflect an important pathway linking abnormal insulin metabolism with endothelial dysfunction in RA.

Original language	English
Pages (from-to)	176-81
Number of pages	6
Journal	Scandinavian Journal of Rheumatology
Volume	42
Issue number	3
DOIs	https://doi.org/10.3109/03009742.2012.747627
Publication status	Published - 2013
Externally published	Yes

Keywords

Adult
Aged
Arginine
Arthritis, Rheumatoid
Female
Homeostasis
Humans
Insulin Resistance
Male
Middle Aged
Journal Article
Research Support, Non-U.S. Gov't

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10.3109/03009742.2012.747627

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Dimitroulas, T., Sandoo, A., Veldhuijzen van Zanten, J. J. J. C. S., Smith, J. P., Hodson, J., Metsios, G. S., Stavropoulos-Kalinoglou, A., & Kitas, G. D. (2013). Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance. Scandinavian Journal of Rheumatology, 42(3), 176-81. https://doi.org/10.3109/03009742.2012.747627

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title = "Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance",

abstract = "OBJECTIVE: To determine whether demographic, inflammatory, and metabolic factors predict elevated asymmetric dimethylarginine (ADMA) levels in rheumatoid arthritis (RA).METHOD: A total of 67 RA patients [mean age 56 ± 12 years, median disease duration 8 (3-15) years] were assessed. Routine biochemistry tests, lipid profile, glycaemic profile [glucose, insulin, homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI)], and inflammatory markers were measured in all patients. ADMA levels were measured by enzyme-linked immunosorbent assay (ELISA). Regression analyses were performed to identify predictors of ADMA in RA.RESULTS: Regression analysis revealed that HOMA (β = 0.149, p = 0.003) was an independent predictor of ADMA in RA. From the drug factors, anti-hypertensive medication use was associated with lower ADMA levels (β = -0.081, p = 0.004). ADMA was not associated with RA disease-related parameters or any of the other cardiovascular risk factors that were assessed.CONCLUSIONS: HOMA, a strong indicator of insulin resistance, seems to be the main predictor of elevated ADMA levels in RA patients; ADMA may reflect an important pathway linking abnormal insulin metabolism with endothelial dysfunction in RA.",

keywords = "Adult, Aged, Arginine, Arthritis, Rheumatoid, Female, Homeostasis, Humans, Insulin Resistance, Male, Middle Aged, Journal Article, Research Support, Non-U.S. Gov't",

author = "T Dimitroulas and A Sandoo and \{Veldhuijzen van Zanten\}, \{J J J C S\} and Smith, \{J P\} and J Hodson and Metsios, \{G S\} and A Stavropoulos-Kalinoglou and Kitas, \{G D\}",

year = "2013",

doi = "10.3109/03009742.2012.747627",

language = "English",

volume = "42",

pages = "176--81",

journal = "Scandinavian Journal of Rheumatology",

issn = "0300-9742",

publisher = "Taylor \& Francis",

number = "3",

}

Dimitroulas, T, Sandoo, A, Veldhuijzen van Zanten, JJJCS, Smith, JP, Hodson, J, Metsios, GS, Stavropoulos-Kalinoglou, A & Kitas, GD 2013, 'Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance', Scandinavian Journal of Rheumatology, vol. 42, no. 3, pp. 176-81. https://doi.org/10.3109/03009742.2012.747627

TY - JOUR

T1 - Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis

T2 - the role of insulin resistance

AU - Dimitroulas, T

AU - Sandoo, A

AU - Veldhuijzen van Zanten, J J J C S

AU - Smith, J P

AU - Hodson, J

AU - Metsios, G S

AU - Stavropoulos-Kalinoglou, A

AU - Kitas, G D

PY - 2013

Y1 - 2013

N2 - OBJECTIVE: To determine whether demographic, inflammatory, and metabolic factors predict elevated asymmetric dimethylarginine (ADMA) levels in rheumatoid arthritis (RA).METHOD: A total of 67 RA patients [mean age 56 ± 12 years, median disease duration 8 (3-15) years] were assessed. Routine biochemistry tests, lipid profile, glycaemic profile [glucose, insulin, homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI)], and inflammatory markers were measured in all patients. ADMA levels were measured by enzyme-linked immunosorbent assay (ELISA). Regression analyses were performed to identify predictors of ADMA in RA.RESULTS: Regression analysis revealed that HOMA (β = 0.149, p = 0.003) was an independent predictor of ADMA in RA. From the drug factors, anti-hypertensive medication use was associated with lower ADMA levels (β = -0.081, p = 0.004). ADMA was not associated with RA disease-related parameters or any of the other cardiovascular risk factors that were assessed.CONCLUSIONS: HOMA, a strong indicator of insulin resistance, seems to be the main predictor of elevated ADMA levels in RA patients; ADMA may reflect an important pathway linking abnormal insulin metabolism with endothelial dysfunction in RA.

AB - OBJECTIVE: To determine whether demographic, inflammatory, and metabolic factors predict elevated asymmetric dimethylarginine (ADMA) levels in rheumatoid arthritis (RA).METHOD: A total of 67 RA patients [mean age 56 ± 12 years, median disease duration 8 (3-15) years] were assessed. Routine biochemistry tests, lipid profile, glycaemic profile [glucose, insulin, homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI)], and inflammatory markers were measured in all patients. ADMA levels were measured by enzyme-linked immunosorbent assay (ELISA). Regression analyses were performed to identify predictors of ADMA in RA.RESULTS: Regression analysis revealed that HOMA (β = 0.149, p = 0.003) was an independent predictor of ADMA in RA. From the drug factors, anti-hypertensive medication use was associated with lower ADMA levels (β = -0.081, p = 0.004). ADMA was not associated with RA disease-related parameters or any of the other cardiovascular risk factors that were assessed.CONCLUSIONS: HOMA, a strong indicator of insulin resistance, seems to be the main predictor of elevated ADMA levels in RA patients; ADMA may reflect an important pathway linking abnormal insulin metabolism with endothelial dysfunction in RA.

KW - Adult

KW - Aged

KW - Arginine

KW - Arthritis, Rheumatoid

KW - Female

KW - Homeostasis

KW - Humans

KW - Insulin Resistance

KW - Male

KW - Middle Aged

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.3109/03009742.2012.747627

DO - 10.3109/03009742.2012.747627

M3 - Article

C2 - 23311682

SN - 0300-9742

VL - 42

SP - 176

EP - 181

JO - Scandinavian Journal of Rheumatology

JF - Scandinavian Journal of Rheumatology

IS - 3

ER -

Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance

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Keywords

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