Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway

P.J. Murphy; D.M. Evans; P.N. Horton; M.B. Hursthouse

doi:10.1039/C4RA03031A

Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway

P.J. Murphy, D.M. Evans, P.N. Horton, M.B. Hursthouse

Research output: Contribution to journal › Article › peer-review

Abstract

Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24.

Original language	English
Pages (from-to)	20744-20751
Journal	RSC Advances
Volume	4
Issue number	40
DOIs	https://doi.org/10.1039/C4RA03031A
Publication status	Published - 28 Apr 2014

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title = "Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway",

abstract = "Two tricyclic guanidine model compounds 28 and 29 have been prepared in 12 steps from 1,5-pentanediol using a biomimetic synthetic approach. The pivotal reaction in the sequence is a tethered Biginelli condensation between 21/22 and β-keto esters 23 and 24.",

author = "P.J. Murphy and D.M. Evans and P.N. Horton and M.B. Hursthouse",

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Preparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway

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