Randomised treatment of acute pancreatitis with infliximab: protocol for a double-blind, placebo-controlled, multi-centre, adaptive, phase 2 superiority trial (RAPID-I)

Juan Lin; Matt Smyth; Catherine Spowart; Michaela Brown; Ian Powell; Diane Latawiec; Di Wu; Wei Huang; Rajarshi Mukherjee; Peter Szatmary; Ryan Baron; Declan Dunne; Jonathan Evans; Sidharth Srinivas; Giles Bond-Smith; Jamie Cooper; Andrew Smith; Antonio Manzelli; Samer Elkhodair; David O’Reilly; Vikramjit Mitra; Richard Body; Ajith Kumar Siriwardena; Sreedhar Subramanian; Catrin Plumpton; Dyfrig A Hughes; Tor Mclaren; Amy Lucas; Carrol Gamble; Thomas Jaki; Robert Sutton

doi:10.1136/bmjopen-2026-118729

Randomised treatment of acute pancreatitis with infliximab: protocol for a double-blind, placebo-controlled, multi-centre, adaptive, phase 2 superiority trial (RAPID-I)

Juan Lin
, Matt Smyth
, Catherine Spowart
, Michaela Brown
, Ian Powell
, Diane Latawiec
, Di Wu
, Wei Huang
, Rajarshi Mukherjee
, Peter Szatmary
, Ryan Baron
, Declan Dunne
, Jonathan Evans
, Sidharth Srinivas
, Giles Bond-Smith
, Jamie Cooper
, Andrew Smith
, Antonio Manzelli
, Samer Elkhodair
, David O’Reilly

Vikramjit Mitra, Richard Body, Ajith Kumar Siriwardena, Sreedhar Subramanian, Catrin Plumpton, Dyfrig A Hughes, Tor Mclaren, Amy Lucas, Carrol Gamble, Thomas Jaki, Robert Sutton

North Wales Medical School

University of Liverpool
The First Affiliated Hospital With Nanjing Medical University
West China Hospital of Sichuan University
Liverpool University Hospitals NHS Foundation Trust
Oxford University Hospitals NHS Foundation Trust
Aberdeen Royal Infirmary
Leeds Teaching Hospitals NHS Trust
Royal Devon University Healthcare NHS Foundation Trust, Exeter
University College London Hospitals NHS Foundation Trust
University Hospital of Wales
North Tees and Hartlepool NHS Foundation Trust
The University of Manchester
Central Manchester University Hospitals NHS Foundation Trust
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	e118729
Journal	BMJ Open
Volume	16
Issue number	9
Early online date	18 Sept 2026
DOIs	https://doi.org/10.1136/bmjopen-2026-118729
Publication status	E-pub ahead of print - 18 Sept 2026

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Cite this

Lin, J., Smyth, M., Spowart, C., Brown, M., Powell, I., Latawiec, D., Wu, D., Huang, W., Mukherjee, R., Szatmary, P., Baron, R., Dunne, D., Evans, J., Srinivas, S., Bond-Smith, G., Cooper, J., Smith, A., Manzelli, A., Elkhodair, S., ... Sutton, R. (2026). Randomised treatment of acute pancreatitis with infliximab: protocol for a double-blind, placebo-controlled, multi-centre, adaptive, phase 2 superiority trial (RAPID-I). BMJ Open, 16(9), Article e118729. Advance online publication. https://doi.org/10.1136/bmjopen-2026-118729

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title = "Randomised treatment of acute pancreatitis with infliximab: protocol for a double-blind, placebo-controlled, multi-centre, adaptive, phase 2 superiority trial (RAPID-I)",

author = "Juan Lin and Matt Smyth and Catherine Spowart and Michaela Brown and Ian Powell and Diane Latawiec and Di Wu and Wei Huang and Rajarshi Mukherjee and Peter Szatmary and Ryan Baron and Declan Dunne and Jonathan Evans and Sidharth Srinivas and Giles Bond-Smith and Jamie Cooper and Andrew Smith and Antonio Manzelli and Samer Elkhodair and David O{\textquoteright}Reilly and Vikramjit Mitra and Richard Body and Siriwardena, \{Ajith Kumar\} and Sreedhar Subramanian and Catrin Plumpton and Hughes, \{Dyfrig A\} and Tor Mclaren and Amy Lucas and Carrol Gamble and Thomas Jaki and Robert Sutton",

year = "2026",

month = sep,

day = "18",

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language = "English",

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Lin, J, Smyth, M, Spowart, C, Brown, M, Powell, I, Latawiec, D, Wu, D, Huang, W, Mukherjee, R, Szatmary, P, Baron, R, Dunne, D, Evans, J, Srinivas, S, Bond-Smith, G, Cooper, J, Smith, A, Manzelli, A, Elkhodair, S, O’Reilly, D, Mitra, V, Body, R, Siriwardena, AK, Subramanian, S, Plumpton, C , Hughes, DA, Mclaren, T, Lucas, A, Gamble, C, Jaki, T & Sutton, R 2026, 'Randomised treatment of acute pancreatitis with infliximab: protocol for a double-blind, placebo-controlled, multi-centre, adaptive, phase 2 superiority trial (RAPID-I)', BMJ Open, vol. 16, no. 9, e118729. https://doi.org/10.1136/bmjopen-2026-118729

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T1 - Randomised treatment of acute pancreatitis with infliximab: protocol for a double-blind, placebo-controlled, multi-centre, adaptive, phase 2 superiority trial (RAPID-I)

AU - Lin, Juan

AU - Smyth, Matt

AU - Spowart, Catherine

AU - Brown, Michaela

AU - Powell, Ian

AU - Latawiec, Diane

AU - Wu, Di

AU - Huang, Wei

AU - Mukherjee, Rajarshi

AU - Szatmary, Peter

AU - Baron, Ryan

AU - Dunne, Declan

AU - Evans, Jonathan

AU - Srinivas, Sidharth

AU - Bond-Smith, Giles

AU - Cooper, Jamie

AU - Smith, Andrew

AU - Manzelli, Antonio

AU - Elkhodair, Samer

AU - O’Reilly, David

AU - Mitra, Vikramjit

AU - Body, Richard

AU - Siriwardena, Ajith Kumar

AU - Subramanian, Sreedhar

AU - Plumpton, Catrin

AU - Hughes, Dyfrig A

AU - Mclaren, Tor

AU - Lucas, Amy

AU - Gamble, Carrol

AU - Jaki, Thomas

AU - Sutton, Robert

PY - 2026/9/18

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DO - 10.1136/bmjopen-2026-118729

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SN - 2044-6055

VL - 16

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JF - BMJ Open

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