TY - JOUR
T1 - Scaling-up Engineering Biology for Enhanced Environmental Solutions
AU - Hassard, Francis
AU - Curtis, Thomas P
AU - Dotro, Gabriela C
AU - Golyshin, Peter
AU - Gutierrez, Tony
AU - Heaven, Sonia
AU - Horsfall, Louise
AU - Jefferson, Bruce
AU - Jones, Davey L
AU - Krasnogor, Natalio
AU - Kumar, Vinod
AU - Lea-Smith, David J
AU - Le Corre Pidou, Kristell
AU - Liu, Yongqiang
AU - Lyu, Tao
AU - McCarthy, Ronan R
AU - McKew, Boyd
AU - Smith, Cindy
AU - Yakunin, Alexander
AU - Yang, Zhugen
AU - Zhang, Yue
AU - Coulon, Frederic
PY - 2024/6/21
Y1 - 2024/6/21
N2 - Synthetic biology (SynBio) offers transformative solutions for addressing environmental challenges by engineering organisms capable of degrading pollutants, enhancing carbon sequestration, and valorizing waste (Figure 1). These innovations hold the potential to revolutionize bioremediation strategies, ecosystem restoration, and sustainable environmental management. (1) Advances in SynBio, including automation, precise manipulation of genetic material, (2) and design of semisynthetic organisms with enhanced capabilities, can improve the efficiency of microbes for eliminating pollutants such as hydrocarbons and plastics or extracting valuable resources from the environment. (3) Genome editing technologies, such as CRISPR-Cas9, allows the editing of genomes with unprecedented accuracy, facilitating the development of organisms with desired traits or functions. (4) Furthermore, SynBio encompasses the engineering of metabolic enzymes within organisms, leading to the design of microbial factories capable of degrading complex and persistent chemicals, and converting waste to valuable resources. (5) These advancements also facilitate the manipulation of bacterial social behaviors, offering the capacity for tunable control at the multicellular level and engineered biofilms. (5)
AB - Synthetic biology (SynBio) offers transformative solutions for addressing environmental challenges by engineering organisms capable of degrading pollutants, enhancing carbon sequestration, and valorizing waste (Figure 1). These innovations hold the potential to revolutionize bioremediation strategies, ecosystem restoration, and sustainable environmental management. (1) Advances in SynBio, including automation, precise manipulation of genetic material, (2) and design of semisynthetic organisms with enhanced capabilities, can improve the efficiency of microbes for eliminating pollutants such as hydrocarbons and plastics or extracting valuable resources from the environment. (3) Genome editing technologies, such as CRISPR-Cas9, allows the editing of genomes with unprecedented accuracy, facilitating the development of organisms with desired traits or functions. (4) Furthermore, SynBio encompasses the engineering of metabolic enzymes within organisms, leading to the design of microbial factories capable of degrading complex and persistent chemicals, and converting waste to valuable resources. (5) These advancements also facilitate the manipulation of bacterial social behaviors, offering the capacity for tunable control at the multicellular level and engineered biofilms. (5)
KW - Synthetic Biology/methods
U2 - 10.1021/acssynbio.4c00292
DO - 10.1021/acssynbio.4c00292
M3 - Article
C2 - 38903005
SN - 2161-5063
VL - 13
SP - 1586
EP - 1588
JO - ACS synthetic biology
JF - ACS synthetic biology
IS - 6
ER -