Social behavior and characteristics of autism spectrum disorder in Angelman, Cornelia de Lange, and Cri du Chat syndromes

Joanna Moss; Patricia Howlin; Richard Patrick Hastings; Sarah Beaumont; Gemma M Griffith; Jane Petty; Penny Tunnicliffe; Rachel Yates; Darrelle Villa; Chris Oliver

doi:10.1352/1944-7558-118.4.262

Social behavior and characteristics of autism spectrum disorder in Angelman, Cornelia de Lange, and Cri du Chat syndromes

Joanna Moss, Patricia Howlin, Richard Patrick Hastings, Sarah Beaumont, Gemma M Griffith, Jane Petty, Penny Tunnicliffe, Rachel Yates, Darrelle Villa, Chris Oliver

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; n = 19; mean age = 10.35 years), Cornelia de Lange (CdLS; n = 15; mean age = 12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; n = 19; mean age = 8.80 years) syndromes. The proportion of individuals meeting the ASD cutoff on the Social Communication Questionnaire was significantly higher in the AS and CdLS groups than in the CdCS group (p < .01). The groups demonstrated divergent social behavior profiles during social conditions in which adult availability, adult familiarity, and social demand were manipulated. Social enjoyment was significantly heightened in AS, whereas social approaches were heightened in individuals with CdCS. Social motivation, social communication, and enjoyment were significantly lower in CdLS. The findings highlight the importance of detailed observation when evaluating ASD and social behavior in genetic syndromes.

Original language	English
Pages (from-to)	262-83
Number of pages	22
Journal	American Journal on Intellectual and Developmental Disabilities
Volume	118
Issue number	4
DOIs	https://doi.org/10.1352/1944-7558-118.4.262
Publication status	Published - Jul 2013

Keywords

Adolescent
Adult
Angelman Syndrome
Child
Child Development Disorders, Pervasive
Child, Preschool
Comorbidity
Cri-du-Chat Syndrome
De Lange Syndrome
Female
Humans
Interpersonal Relations
Male
Phenotype
Psychiatric Status Rating Scales
Psychological Tests
Qualitative Research
Social Behavior
Surveys and Questionnaires
Young Adult
Comparative Study
Journal Article

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10.1352/1944-7558-118.4.262

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Moss, J., Howlin, P., Hastings, R. P., Beaumont, S., Griffith, G. M., Petty, J., Tunnicliffe, P., Yates, R., Villa, D., & Oliver, C. (2013). Social behavior and characteristics of autism spectrum disorder in Angelman, Cornelia de Lange, and Cri du Chat syndromes. American Journal on Intellectual and Developmental Disabilities, 118(4), 262-83. https://doi.org/10.1352/1944-7558-118.4.262

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title = "Social behavior and characteristics of autism spectrum disorder in Angelman, Cornelia de Lange, and Cri du Chat syndromes",

abstract = "We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; n = 19; mean age = 10.35 years), Cornelia de Lange (CdLS; n = 15; mean age = 12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; n = 19; mean age = 8.80 years) syndromes. The proportion of individuals meeting the ASD cutoff on the Social Communication Questionnaire was significantly higher in the AS and CdLS groups than in the CdCS group (p < .01). The groups demonstrated divergent social behavior profiles during social conditions in which adult availability, adult familiarity, and social demand were manipulated. Social enjoyment was significantly heightened in AS, whereas social approaches were heightened in individuals with CdCS. Social motivation, social communication, and enjoyment were significantly lower in CdLS. The findings highlight the importance of detailed observation when evaluating ASD and social behavior in genetic syndromes.",

keywords = "Adolescent, Adult, Angelman Syndrome, Child, Child Development Disorders, Pervasive, Child, Preschool, Comorbidity, Cri-du-Chat Syndrome, De Lange Syndrome, Female, Humans, Interpersonal Relations, Male, Phenotype, Psychiatric Status Rating Scales, Psychological Tests, Qualitative Research, Social Behavior, Surveys and Questionnaires, Young Adult, Comparative Study, Journal Article",

author = "Joanna Moss and Patricia Howlin and Hastings, \{Richard Patrick\} and Sarah Beaumont and Griffith, \{Gemma M\} and Jane Petty and Penny Tunnicliffe and Rachel Yates and Darrelle Villa and Chris Oliver",

year = "2013",

month = jul,

doi = "10.1352/1944-7558-118.4.262",

language = "English",

volume = "118",

pages = "262--83",

journal = "American Journal on Intellectual and Developmental Disabilities",

issn = "1944-7515",

publisher = "American Association on Intellectual and Developmental Disabilities",

number = "4",

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Moss, J, Howlin, P, Hastings, RP, Beaumont, S, Griffith, GM, Petty, J, Tunnicliffe, P, Yates, R, Villa, D & Oliver, C 2013, 'Social behavior and characteristics of autism spectrum disorder in Angelman, Cornelia de Lange, and Cri du Chat syndromes', American Journal on Intellectual and Developmental Disabilities, vol. 118, no. 4, pp. 262-83. https://doi.org/10.1352/1944-7558-118.4.262

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T1 - Social behavior and characteristics of autism spectrum disorder in Angelman, Cornelia de Lange, and Cri du Chat syndromes

AU - Moss, Joanna

AU - Howlin, Patricia

AU - Hastings, Richard Patrick

AU - Beaumont, Sarah

AU - Griffith, Gemma M

AU - Petty, Jane

AU - Tunnicliffe, Penny

AU - Yates, Rachel

AU - Villa, Darrelle

AU - Oliver, Chris

PY - 2013/7

Y1 - 2013/7

N2 - We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; n = 19; mean age = 10.35 years), Cornelia de Lange (CdLS; n = 15; mean age = 12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; n = 19; mean age = 8.80 years) syndromes. The proportion of individuals meeting the ASD cutoff on the Social Communication Questionnaire was significantly higher in the AS and CdLS groups than in the CdCS group (p < .01). The groups demonstrated divergent social behavior profiles during social conditions in which adult availability, adult familiarity, and social demand were manipulated. Social enjoyment was significantly heightened in AS, whereas social approaches were heightened in individuals with CdCS. Social motivation, social communication, and enjoyment were significantly lower in CdLS. The findings highlight the importance of detailed observation when evaluating ASD and social behavior in genetic syndromes.

AB - We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; n = 19; mean age = 10.35 years), Cornelia de Lange (CdLS; n = 15; mean age = 12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; n = 19; mean age = 8.80 years) syndromes. The proportion of individuals meeting the ASD cutoff on the Social Communication Questionnaire was significantly higher in the AS and CdLS groups than in the CdCS group (p < .01). The groups demonstrated divergent social behavior profiles during social conditions in which adult availability, adult familiarity, and social demand were manipulated. Social enjoyment was significantly heightened in AS, whereas social approaches were heightened in individuals with CdCS. Social motivation, social communication, and enjoyment were significantly lower in CdLS. The findings highlight the importance of detailed observation when evaluating ASD and social behavior in genetic syndromes.

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KW - Adult

KW - Angelman Syndrome

KW - Child

KW - Child Development Disorders, Pervasive

KW - Child, Preschool

KW - Comorbidity

KW - Cri-du-Chat Syndrome

KW - De Lange Syndrome

KW - Female

KW - Humans

KW - Interpersonal Relations

KW - Male

KW - Phenotype

KW - Psychiatric Status Rating Scales

KW - Psychological Tests

KW - Qualitative Research

KW - Social Behavior

KW - Surveys and Questionnaires

KW - Young Adult

KW - Comparative Study

KW - Journal Article

U2 - 10.1352/1944-7558-118.4.262

DO - 10.1352/1944-7558-118.4.262

M3 - Article

C2 - 23937369

SN - 1944-7515

VL - 118

SP - 262

EP - 283

JO - American Journal on Intellectual and Developmental Disabilities

JF - American Journal on Intellectual and Developmental Disabilities

IS - 4

ER -

Social behavior and characteristics of autism spectrum disorder in Angelman, Cornelia de Lange, and Cri du Chat syndromes

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Keywords

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