Synthesis of (+)-(R)-Tiruchanduramine

Zahraa S. Al-Taie; Barbara Bartholomew; Christopher  Cartmell; Richard Froom; Russell G. Kerr; Rolf Kraehenbuehl; Paddy Murphy; Robert J. Nash; Yana B. Penkova; Alexander  van Teijlingen

doi:10.3390/molecules27041338

Synthesis of (+)-(R)-Tiruchanduramine

Zahraa S. Al-Taie, Barbara Bartholomew, Christopher Cartmell, Richard Froom, Russell G. Kerr, Rolf Kraehenbuehl, Paddy Murphy, Robert J. Nash, Yana B. Penkova, Alexander van Teijlingen

School of Environmental & Natural Sciences

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Abstract

The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5% overall yield from Fmoc-D-Dab(Boc)-OH.

Original language	English
Journal	Molecules
Volume	27
Issue number	4
DOIs	https://doi.org/10.3390/molecules27041338
Publication status	Published - 16 Feb 2022

Keywords

Synoicum macroglossum
beta-carboline
guanidines
tiruchanduramine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules27041338Licence: CC BY

molecules-27-01338Final published version, 1.71 MBLicence: CC BY

Cite this

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title = "Synthesis of (+)-(R)-Tiruchanduramine",

abstract = "The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5\% overall yield from Fmoc-D-Dab(Boc)-OH. ",

keywords = "Synoicum macroglossum, beta-carboline, guanidines, tiruchanduramine",

author = "Al-Taie, \{Zahraa S.\} and Barbara Bartholomew and Christopher Cartmell and Richard Froom and Kerr, \{Russell G.\} and Rolf Kraehenbuehl and Paddy Murphy and Nash, \{Robert J.\} and Penkova, \{Yana B.\} and \{van Teijlingen\}, Alexander",

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language = "English",

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AU - Al-Taie, Zahraa S.

AU - Bartholomew, Barbara

AU - Cartmell, Christopher

AU - Froom, Richard

AU - Kerr, Russell G.

AU - Kraehenbuehl, Rolf

AU - Murphy, Paddy

AU - Nash, Robert J.

AU - Penkova, Yana B.

AU - van Teijlingen, Alexander

PY - 2022/2/16

Y1 - 2022/2/16

N2 - The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5% overall yield from Fmoc-D-Dab(Boc)-OH.

AB - The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5% overall yield from Fmoc-D-Dab(Boc)-OH.

KW - Synoicum macroglossum

KW - beta-carboline

KW - guanidines

KW - tiruchanduramine

U2 - 10.3390/molecules27041338

DO - 10.3390/molecules27041338

M3 - Article

SN - 1420-3049

VL - 27

JO - Molecules

JF - Molecules

IS - 4

ER -

Synthesis of (+)-(R)-Tiruchanduramine

Abstract

Keywords

UN SDGs

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