Thiol modified mycolic acids

Mohammed O Balogun, Enlli H Huws, Muthana M Sirhan, Ahmed D Saleh, Juma'a R Al Dulayymi, Lynne Pilcher, Jan A Verschoor, Mark S Baird

Research output: Contribution to journalArticlepeer-review

Abstract

Patient serum antibodies to mycolic acids have the potential to be surrogate markers of active tuberculosis (TB) when they can be distinguished from the ubiquitously present cross-reactive antibodies to cholesterol. Mycolic acids are known to interact more strongly with antibodies present in the serum of patients with active TB than in patients with latent TB or no TB. Examples of single stereoisomers of mycolic acids with chain lengths corresponding to major homologues of those present in Mycobacterium tuberculosis have now been synthesised with a sulfur substituent on the terminal position of the α-chain; initial studies have established that one of these binds to a gold electrode surface, offering the potential to develop second generation sensors for diagnostic patient antibody detection.
Original languageEnglish
Pages (from-to)40-57
Number of pages16
JournalChemistry and Physics of Lipids
Volume172-173
Issue numberJuly-August
Early online date18 Apr 2013
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Antibodies/immunology
  • Electrochemical Techniques
  • Electrodes
  • Humans
  • Mycolic Acids/chemical synthesis
  • Stereoisomerism
  • Sulfhydryl Compounds/chemistry
  • Tuberculosis/immunology

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