Translin-Trax: Considerations for Oncological Therapeutic Targeting

Ramsay J. McFarlane; Jane A. Wakeman

doi:10.1016/j.trecan.2020.02.014

Translin-Trax: Considerations for Oncological Therapeutic Targeting

Research output: Contribution to journal › Article › peer-review

Abstract

Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consider how this complexity could influence therapeutic design strategies.

Original language	English
Pages (from-to)	450-453
Number of pages	4
Journal	Trends in Cancer
Volume	6
Issue number	6
Early online date	16 Mar 2020
DOIs	https://doi.org/10.1016/j.trecan.2020.02.014
Publication status	Published - Jun 2020

Keywords

Translin-Trax
Dicer
drug development
miRNA
DNA repair

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.trecan.2020.02.014

https://www.sciencedirect.com/science/article/pii/S2405803320300753

Cite this

@article{2c064c143ded440bb9d20fb6f456b7f2,

title = "Translin-Trax: Considerations for Oncological Therapeutic Targeting",

abstract = "Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consider how this complexity could influence therapeutic design strategies.",

keywords = "Translin-Trax, Dicer, drug development, miRNA, DNA repair",

author = "McFarlane, \{Ramsay J.\} and Wakeman, \{Jane A.\}",

year = "2020",

month = jun,

doi = "10.1016/j.trecan.2020.02.014",

language = "English",

volume = "6",

pages = "450--453",

journal = "Trends in Cancer",

issn = "2405-8033",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Translin-Trax: Considerations for Oncological Therapeutic Targeting

AU - McFarlane, Ramsay J.

AU - Wakeman, Jane A.

PY - 2020/6

Y1 - 2020/6

N2 - Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consider how this complexity could influence therapeutic design strategies.

AB - Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn-Tx functions in an array of biological processes, and here we consider how this complexity could influence therapeutic design strategies.

KW - Translin-Trax

KW - Dicer

KW - drug development

KW - miRNA

KW - DNA repair

U2 - 10.1016/j.trecan.2020.02.014

DO - 10.1016/j.trecan.2020.02.014

M3 - Article

SN - 2405-8033

VL - 6

SP - 450

EP - 453

JO - Trends in Cancer

JF - Trends in Cancer

IS - 6

ER -

Translin-Trax: Considerations for Oncological Therapeutic Targeting

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this