UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

Dharmisha Chauhan; Cinzia Dello Russo; Jack Thompson; Dyfrig A. Hughes; Katherine Payne; Maria Tsakiroglou; Paul Ross; Rena Chauhan; Simon Jenkinson; Jessica Keen; Sophie Harding; Eleanor Lau; Michael Braun; Roshan Agarwal; Richard Adams; Elisabeth Rolf; Farah Al‐Sheikhli; Sarah Mitchell; Ruth Hammond; Rosie Roberts; Lorna Cairns; Shirley Heggarty; Janet Graham; Justin Mencel; Munir Pirmohamed

doi:10.1002/bcp.70659

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

Dharmisha Chauhan
, Cinzia Dello Russo
, Jack Thompson
, Dyfrig A. Hughes
, Katherine Payne
, Maria Tsakiroglou
, Paul Ross
, Rena Chauhan
, Simon Jenkinson
, Jessica Keen
, Sophie Harding
, Eleanor Lau
, Michael Braun
, Roshan Agarwal
, Richard Adams
, Elisabeth Rolf
, Farah Al‐Sheikhli
, Sarah Mitchell
, Ruth Hammond
, Rosie Roberts

Lorna Cairns, Shirley Heggarty, Janet Graham, Justin Mencel, Munir Pirmohamed

North Wales Medical School

Great Ormond Street Hospital for Children NHS Foundation Trust
University of Liverpool
Guy's and St Thomas' NHS Foundation Trust
University of Manchester
Royal Free London NHS Foundation Trust
Christie Hospital NHS Foundation Trust
University Hospital of Wales
Swansea Bay University Health Board
University Hospitals of Northamptonshire
Velindre University NHS Trust
Royal Marsden NHS Foundation Trust
Dorset County Hospital NHS Foundation Trust
Mount Alvernia Hospital
Western Health and Social Care Trust
Belfast Health and Social Care Trust, Belfast
West of Scotland Cancer Network

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	British Journal of Clinical Pharmacology
Early online date	2 Jul 2026
DOIs	https://doi.org/10.1002/bcp.70659
Publication status	E-pub ahead of print - 2 Jul 2026

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Embargoed Document

The UK Pharmacogenomics Guidelines for the use of IRINOTECAN UGT1A1_CERSIPGx v19 Final_
Accepted author manuscript, 509 KB
Embargo ends: 02/07/2027 00:00 BST

Cite this

Chauhan, D., Dello Russo, C., Thompson, J., Hughes, D. A., Payne, K., Tsakiroglou, M., Ross, P., Chauhan, R., Jenkinson, S., Keen, J., Harding, S., Lau, E., Braun, M., Agarwal, R., Adams, R., Rolf, E., Al‐Sheikhli, F., Mitchell, S., Hammond, R., ... Pirmohamed, M. (2026). UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx). British Journal of Clinical Pharmacology. Advance online publication. https://doi.org/10.1002/bcp.70659

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Chauhan, D, Dello Russo, C, Thompson, J, Hughes, DA, Payne, K, Tsakiroglou, M, Ross, P, Chauhan, R, Jenkinson, S, Keen, J, Harding, S, Lau, E, Braun, M, Agarwal, R, Adams, R, Rolf, E, Al‐Sheikhli, F, Mitchell, S, Hammond, R, Roberts, R, Cairns, L, Heggarty, S, Graham, J, Mencel, J & Pirmohamed, M 2026, 'UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)', British Journal of Clinical Pharmacology. https://doi.org/10.1002/bcp.70659

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AU - Chauhan, Dharmisha

AU - Dello Russo, Cinzia

AU - Thompson, Jack

AU - Hughes, Dyfrig A.

AU - Payne, Katherine

AU - Tsakiroglou, Maria

AU - Ross, Paul

AU - Chauhan, Rena

AU - Jenkinson, Simon

AU - Keen, Jessica

AU - Harding, Sophie

AU - Lau, Eleanor

AU - Braun, Michael

AU - Agarwal, Roshan

AU - Adams, Richard

AU - Rolf, Elisabeth

AU - Al‐Sheikhli, Farah

AU - Mitchell, Sarah

AU - Hammond, Ruth

AU - Roberts, Rosie

AU - Cairns, Lorna

AU - Heggarty, Shirley

AU - Graham, Janet

AU - Mencel, Justin

AU - Pirmohamed, Munir

PY - 2026/7/2

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SN - 0306-5251

JO - British Journal of Clinical Pharmacology

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