Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels

Qian Xu; Manon Venet; Wei WAng; Jack Creagh-Flynn; Xi Wang; Xiaolin Li; Yongshenng Gao; Dezhong Zhou; Ming Zeng; Irene Lara-Saez; Sigen A; Hongyun Tai; Wenxin Wang

doi:10.1021/acsami.8b15006

Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels

Qian Xu, Manon Venet, Wei WAng, Jack Creagh-Flynn, Xi Wang, Xiaolin Li, Yongshenng Gao, Dezhong Zhou, Ming Zeng, Irene Lara-Saez, Sigen A, Hongyun Tai, Wenxin Wang

School of Environmental & Natural Sciences

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Abstract

Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful platform for regu-lating critical aspects of ROS-induced pathologies and can improve such hostile microenvironments. Here, we report a se-ries of new hyperbranched poly(β-hydrazide ester) macromers (HB-PBHEs) with disulfide moieties synthesized via an “A2+B4” Michael addition approach. The three-dimensional structure of HB-PBHEs with multi-acrylate end groups endows the macromers with rapid gelation capabilities to form (1) injectable hydrogels via crosslinking with thiolated hyaluronic acid, and (2) robust UV-crosslinked hydrogels. The disulfide containing macromers and hydrogels exhibit H2O2-responsive degradation compared to the counterparts synthesized by a dihydrazide monomer without disulfide moieties. The cell via-bility under a high ROS environment can be well-maintained under the protection of the disulfide containing hydrogels.

Original language	English
Pages (from-to)	39494-39504
Journal	ACS Applied materials and interfaces
Volume	10
Issue number	46
DOIs	https://doi.org/10.1021/acsami.8b15006
Publication status	Published - 30 Oct 2018

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10.1021/acsami.8b15006

Maintext - Prof Wenxin Wang - clean versionAccepted author manuscript, 1.82 MBLicence: CC BY-NC
Supporting Information - Prof Wenxin WangAccepted author manuscript, 1.4 MBLicence: CC BY-NC

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title = "Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels",

abstract = "Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful platform for regu-lating critical aspects of ROS-induced pathologies and can improve such hostile microenvironments. Here, we report a se-ries of new hyperbranched poly(β-hydrazide ester) macromers (HB-PBHEs) with disulfide moieties synthesized via an “A2+B4” Michael addition approach. The three-dimensional structure of HB-PBHEs with multi-acrylate end groups endows the macromers with rapid gelation capabilities to form (1) injectable hydrogels via crosslinking with thiolated hyaluronic acid, and (2) robust UV-crosslinked hydrogels. The disulfide containing macromers and hydrogels exhibit H2O2-responsive degradation compared to the counterparts synthesized by a dihydrazide monomer without disulfide moieties. The cell via-bility under a high ROS environment can be well-maintained under the protection of the disulfide containing hydrogels.",

author = "Qian Xu and Manon Venet and Wei WAng and Jack Creagh-Flynn and Xi Wang and Xiaolin Li and Yongshenng Gao and Dezhong Zhou and Ming Zeng and Irene Lara-Saez and Sigen A and Hongyun Tai and Wenxin Wang",

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AU - Xu, Qian

AU - Venet, Manon

AU - WAng, Wei

AU - Creagh-Flynn, Jack

AU - Wang, Xi

AU - Li, Xiaolin

AU - Gao, Yongshenng

AU - Zhou, Dezhong

AU - Zeng, Ming

AU - Lara-Saez, Irene

AU - A, Sigen

AU - Tai, Hongyun

AU - Wang, Wenxin

PY - 2018/10/30

Y1 - 2018/10/30

N2 - Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful platform for regu-lating critical aspects of ROS-induced pathologies and can improve such hostile microenvironments. Here, we report a se-ries of new hyperbranched poly(β-hydrazide ester) macromers (HB-PBHEs) with disulfide moieties synthesized via an “A2+B4” Michael addition approach. The three-dimensional structure of HB-PBHEs with multi-acrylate end groups endows the macromers with rapid gelation capabilities to form (1) injectable hydrogels via crosslinking with thiolated hyaluronic acid, and (2) robust UV-crosslinked hydrogels. The disulfide containing macromers and hydrogels exhibit H2O2-responsive degradation compared to the counterparts synthesized by a dihydrazide monomer without disulfide moieties. The cell via-bility under a high ROS environment can be well-maintained under the protection of the disulfide containing hydrogels.

AB - Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful platform for regu-lating critical aspects of ROS-induced pathologies and can improve such hostile microenvironments. Here, we report a se-ries of new hyperbranched poly(β-hydrazide ester) macromers (HB-PBHEs) with disulfide moieties synthesized via an “A2+B4” Michael addition approach. The three-dimensional structure of HB-PBHEs with multi-acrylate end groups endows the macromers with rapid gelation capabilities to form (1) injectable hydrogels via crosslinking with thiolated hyaluronic acid, and (2) robust UV-crosslinked hydrogels. The disulfide containing macromers and hydrogels exhibit H2O2-responsive degradation compared to the counterparts synthesized by a dihydrazide monomer without disulfide moieties. The cell via-bility under a high ROS environment can be well-maintained under the protection of the disulfide containing hydrogels.

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JO - ACS Applied materials and interfaces

JF - ACS Applied materials and interfaces

IS - 46

ER -

Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels

Abstract

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