Approaches to methylcyclopropanes and a new route to methylenecyclopropanes

Abstract

Mycolic acids show an unusual variety of structural features including the a-methyl-trans-cyclopropane (61), which is thought to be a key factor in stopping drugs getting into the cells of Mycobacterium tuberculosis.
The synthesis of an optically pure cyclopropane as an intermediate for the synthesis of the trans-a-methyl mycolic acid was achieved as part of this work by preparation of (88).

Date of Award	Jul 2004
Original language	English
Awarding Institution	Bangor University
Supervisor	Mark Baird (Supervisor)