Guanidine glycomimetics

Abstract

This thesis describes the investigation of methodologies towards the synthesis and
purification of 5-, 6- and 7- membered guanidine heterocycles. Methods include
intermolecul ar epoxide ring opening reactions using guanidine and the intramolecular cyclization reactions of N-Boc-allylguanidines and N-Boc-homoallylguanidines in both epoxide ring opening reactions and palladium mediated cyclisations. The possible utility of these heterocycles as glycosidase inhibitors was investigated using enzymatic assays.

Date of Award	2012
Original language	English
Awarding Institution	Bangor University
Sponsors	ESF & Summit (Wales)
Supervisor	Paddy Murphy (Supervisor)