Prof Alexander Iakounine

Professor In Enzyme Discovery and Application

Contact info

 

Professor Alexander Yakunin (Iakounine)

 

Office: Thoday Building, room S25

Email: a.iakounine@bangor.ac.uk

Tel: 01248 388399

 

Research focus: enzyme discovery, enzymology, enzyme applications

  1. Erthygl › Ymchwil › Adolygwyd gan gymheiriaid
  2. A family of metal-dependent phosphatases implicated in metabolite damage-control

    Huang, L., Khusnutdinova, A., Nocek, B., Brown, G., Xu, X., Cui, H., Petit, P., Flick, R., Zallot, R., Balmant, K., Ziemak, M. J., Shanklin, J., de Crecy-Lagard, V., Fiehn, O., Gregory, J. F. . III., Joachimiak, A., Savchenko, A., Yakunin, A. F. & Hanson, A. D., Awst 2016, Yn : Nature Chemical Biology. 12, 8, t. 621-627

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  3. Cyhoeddwyd

    Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families

    Popovic, A., Hai, T., Tchigvintsev, A., Hajighasemi, M., Nocek, B., Khusnutdinova, A. N., Brown, G., Glinos, J., Flick, R., Skarina, T., Chernikova, T., Yim, V., Bruls, T., Le Paslier, D., Yakimov, M. M., Joachimiak, A., Ferrer, M., Golyshina, O., Savchenko, A., Golyshin, P. & Yakunin, A. F., Maw 2017, Yn : Scientific Reports. 7, 44103, 44103.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  4. Alkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid

    Joo, J. C., Khusnutdinova, A. N., Flick, R., Kim, T., Bornscheuer, U. T., Yakunin, A. F. & Mahadevan, R., 1 Chwef 2017, Yn : Chemical Science. 8, 2, t. 1406-1413

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  5. Cyhoeddwyd

    Biochemical and structural insights into enzymatic depolymerization of polylactic acid and other polyesters by microbial carboxylesterases

    Hajighasemi, M., Nocek, B. P., Tchigvintsev, A., Brown, G., Flick, R., Xu, X., Cui, H., Hai, T., Joachimiak, A., Golyshin, P., Savchenko, A., Edwards, E. A. & Yakunin, A. F., 18 Ebr 2016, Yn : Biomacromolecules. 17, 6, t. 2027-2039

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  6. Biosynthesis and activity of prenylated FMN cofactors

    Wang, P-H., Khusnutdinova, A. N., Luo, F., Xiao, J., Nemr, K., Flick, R., Brown, G., Mahadevan, R., Edwards, E. & Yakunin, A., 17 Mai 2018, Yn : Cell Chemical Biology. 25, 5, t. 560-570

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  7. CRISPR RNA binding and DNA target recognition by purified Cascade complexes from Escherichia coli

    Beloglazova, N., Kuznedelov, K., Flick, R., Datsenko, K. A., Brown, G., Popovic, A., Lemak, S., Semenova, E., Severinov, K. & Yakunin, A. F., Ion 2015, Yn : Nucleic Acids Research. 43, 1, t. 530-543

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  8. Cyhoeddwyd

    Determinants and prediction of esterase substrate promiscuity patterns

    Martínez-Martínez, M., Coscolín, C., Santiago, G., Chow, J., Stogios, P. J., Bargiela, R., Gertler, C., Navarro-Fernández, J., Bollinger, A., Thies, S., Méndez-García, C., Popovic, A., Brown, G., Chernikova, T., García-Moyano, A., Bjerga, G. E. K., Perez-Garcia, P., Hai, T., del Pozo, M. V., Stokke, R., Steen, I. H., Cui, H., Xu, X., Nocek, B., Alcaide, M., Disasto, M., Mesa, V., Pelaez, A. I., Sanchez, J., Buchholz, P. C. F., Pleiss, J., Fernández-Guerra, A., Glockner, F. O., Golyshina, O., Yakimov, M. M., Savchenko, A., Jaeger, K-E., Yakunin, A. F., Streit, W. R., Golyshin, P., Guallar, V. & Ferrer, M., 2018, Yn : ACS Chemical Biology. 13, 1, t. 225-234

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  9. Cyhoeddwyd

    Diversity of hydrolases from hydrothermal vent sediments of the Levante Bay, Vulcano Island (Aeolian archipelago) identified by activity-based metagenomics and biochemical characterization of new esterases and an arabinopyranosidase

    Placido, A., Hai, T., Ferrer, M., Chernikova, T. N., Distaso, M. A., Armstrong, D., Yakunin, A. F., Toshchakov, S. V., Yakimov, M. M., Kublanov, I. V., Golyshina, O., Pesole, G., Ceci, L. R. & Golyshin, P., 1 Rhag 2015, Yn : Applied Microbiology and Biotechnology. 99, 23, t. 10031-10046

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  10. Engineering a short, aldolase based pathway for (R)-1,3-butanediol production in Escherichia coli

    Nemr, K., Muller, J., Joo, J. C., Gawand, P., Cjoudhary, R., Mendonca, B., Lu, S., Yu, X., Yakunin, A. & Mahadevan, R., 1 Gorff 2018, Yn : Metabolic Engineering. 48, t. 13-24

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  11. Cyhoeddwyd

    Genome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica

    Golyshina, O., Hai, T., Kube, M., Chernikova, T. N., Al-Ramahi, Y., Beloqui, A., Lopez-Cortez, N., Guazzaroni, M. E., Heipieper, H. J., Klages, S., Kotsyurbenko, O. R., Langer, I., Nechitaylo, T. Y., Lünsdorf, H., Fernández, M., Juárez, S., Ciordia, S., Singer, A., Kagan, O., Egorova, O., Petit, P. A., Stogios, P., Kim, Y., Tchigvintsev, A., Flick, R., Denaro, R., Genovese, M., Albar, J. P., Reva, O. N., Martínez-Gomariz, M., Tran, H., Ferrer, M., Savchenko, A., Yakunin, A. F., Yakimov, M. M., Golyshina, O. V., Reinhardt, R. & Golyshin, P. N., 23 Gorff 2013, Yn : Nature Communications. 4, t. 2156

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  12. Cyhoeddwyd

    Heavy metal removal by bioaccumulation using genetically engineered microorganisms

    Diep, P., Mahadevan, R. & Yakunin, A., 29 Hyd 2018, Yn : Frontiers in Bioengineering and Biotechnology. 6, 157.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  13. Cyhoeddwyd

    Identification and characterization of carboxyl esterases of gill chamber-associated microbiota in the deep-sea shrimp Rimicaris exoculata using functional metagenomics

    Alcaide, M., Tchigvinstsev, A., Martinez-Martinez, M., Popovic, A., Reva, O. N., Lafraya, A., Bargiela, R. N., Nechitaylo, T. Y., Matesanz, R., Cambon-Bonavita, M., Jebbar, M., Savchenko, A., Yakimov, M. M., Golyshina, O., Yakunin, A. F., Golyshin, P., Ferrer, M. & The MAMBA Consortium., N. V., 16 Ion 2015, Yn : Applied and Environmental Microbiology. 81, 6, t. 2125-2136

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  14. Cyhoeddwyd

    Metabolic and evolutionary patterns in the extremely acidophilic archaeon Ferroplasma acidiphilum YT

    Golyshina, O., Hai, T., Reva, O. N., Lemak, S., Yakunin, A. F., Goesmann, A., Nechitaylo, T. Y., LaCono, V., Smedile, F., Slesarev, A., Rojo, D., Barbas, C., Ferrer, M., Yakimov, M. M. & Golyshin, P., 16 Meh 2017, Yn : Scientific Reports. 7, 3682.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  15. Cyhoeddwyd

    Pressure adaptation is linked to thermal adaptation in salt-saturated marine habitats

    Alcaide, M., Stogios, P. J., Lafraya, A., Tchigvintsev, A., Flick, R., Bargiela, R., Chernikova, T. N., Reva, O. N., Hai, T., Leggewie, C. C., Katzke, N., La Cono, V., Matesanz, R., Jebbar, M., Jaeger, K., Yakimov, M. M., Yakunin, A. F., Golyshin, P. N., Golyshina, O. V., Savchenko, A. & Ferrer, M., 17 Rhag 2014, Yn : Environmental Microbiology. 17, 2, t. 332-345

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  16. Cyhoeddwyd

    Relationships between Substrate Promiscuity and Chiral Selectivity of Esterases from Phylogenetically and Environmentally Diverse Microorganisms

    Coscolín, C., Martínez-Martínez, M., Chow, J., Bargiela, R., García-Moyano, A., Bjerga, G. E. K., Bollinger, A., Stokke, R., Steen, I. H., Golyshina, O., Yakimov, M. M., Jaeger, K-E., Yakunin, A. F., Streit, W. R., Golyshin, P. & Ferrer, M., 5 Ion 2018, Yn : Catalysts. 8, 1, 10.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  17. SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia

    Schneider, C., Oellerich, T., Baldauf, H-M., Schwarz, S-M., Thomas, D., Flick, R., Bohnenberger, H., Kaderali, L., Stegmann, L., Cremer, A., Martin, M., Lohmeyer, J., Michaelis, M., Hornung, V., Schliemann, C., Berdel, W. E., Hartmann, W., Wardelmann, E., Comoglio, F., Hansmann, M-L., Yakunin, A. F., Geisslinger, G., Stroebel, P., Ferreiros, N., Serve, H., Keppler, O. T. & Cinatl, J. J., Chwef 2017, Yn : NATURE MEDICINE. 23, 2, t. 250-255

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  18. Cyhoeddwyd

    Screening and Characterization of Novel Polyesterases from Environmental Metagenomes with High Hydrolytic Activity against Synthetic Polyesters

    Hajighasemi, M., Tchigvintsev, A., Nocek, B., Flick, R., Popovic, A., Hai, T., Khusnutdinova, A. N., Brown, G., Xu, X., Cui, H., Anstett, J., Chernikova, T., Bruls, T., Le Paslier, D., Yakimov, M. M., Joachimiak, A., Golyshina, O., Savchenko, A., Golyshin, P., Edwards, E. A. & Yakunin, A. F., 6 Tach 2018, Yn : Environmental Science and Technology. 52, 21, t. 12388-12401

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  19. Cyhoeddwyd

    Site-directed mutagenesis and stability of the carboxylic acid reductase MAB4714 from Mycobacterium abscessus

    Fedorchuk, T. P., Khusnutdinova, A. N., Flick, R. & Yakunin, A., 10 Medi 2019, Yn : Journal of Biotechnology. t. 72-79

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  20. Structural Insights into Substrate Selectivity and Activity of Bacterial Polyphosphate Kinases

    Nocek, B. P., Khusnutdinova, A. N., Ruszkowski, M., Flick, R., Burda, M., Batyrova, K., Brown, G., Mucha, A., Joachimiak, A., Berlicki, L. & Yakunin, A. F., 2 Tach 2018, Yn : Catalysis Today. 8, 11, t. 10746-10760

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  21. Cyhoeddwyd

    Structure and activity of the cold-active and anion-activated carboxyl esterase OLEI01171 from the oil-degrading marine bacterium Oleispira antarctica

    Lemak, S., Tchigvintsev, A., Petit, P., Flick, R., Singer, A. U., Brown, G., Evdokimova, E., Egorova, O., Gonzalez, C. F., Chernikova, T. N., Yakimov, M. M., Kube, M., Reinhardt, R., Golyshin, P. N., Savchenko, A. & Yakunin, A. F., 15 Gorff 2012, Yn : Biochemical Journal. 445, 2, t. 193-203

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  22. The CRISPR-associated Cas4 protein Pcal_0546 from Pyrobaculum calidifontis contains a [2Fe-2S] cluster: crystal structure and nuclease activity

    Lemak, S., Nocek, B., Beloglazova, N., Skarina, T., Flick, R., Brown, G., Joachimiak, A., Savchenko, A. & Yakunin, A. F., 29 Medi 2014, Yn : Nucleic Acids Research. 42, 17, t. 11144-11155

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  23. Cyhoeddwyd

    The environment shapes microbial enzymes: five cold-active and salt-resistant carboxylesterases from marine metagenomes

    Tchigvintsev, A., Tran, H., Popvic, A., Kovacic, F., Brown, G., Flick, R., Hajighasemi, M., Egorova, O., Somody, J. C., Tchigvintsev, D., Khusnutdinova, A., Chernikova, T. N., Golyshina, O., Yakimov, M. M., Savchenko, A., Golyshin, P., Jaeger, K. E. & Yakunin, A. F., 1 Maw 2015, Yn : Applied Microbiology and Biotechnology. 99, 5, t. 2165-2178

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  24. Pennod › Ymchwil › Adolygwyd gan gymheiriaid
  25. Cyhoeddwyd

    Metagenomics as a tool for enzyme discovery: hydrolytic enzymes from marine-related metagenomes

    Popovic, A., Tchigvintsev, A., Tran, H., Chernikova, T. N., Golyshina, O. V., Yakimov, M. M., Golyshin, P. N. & Yakunin, A. F., 2015, Prokaryotic Systems Biology. Springer, t. 1-20 20 t.

    Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion CynhadleddPennod

  26. Cyhoeddwyd

    Prenylated FMN: biosynthesis, purification, and Fdc1 activation

    Khusnutdinova, A. N., Xiao, J., Wang, P-H., Batyrova, K., Flick, R., Edwards, E. & Yakunin, A., 2019, New Approaches for Flavin Catalysis. Palfey, B. A. (gol.). Elsevier, Cyfrol 620. t. 469-488 (Methods in Enzymology).

    Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion CynhadleddPennod