Dr Juma'a Al-Dulayymi

Cynorthwywr Dysgu Ymchwil

Contact info

e-mail: chs00c@bangor.ac.uk

 

telephone: 01248 388121

 

Summary of my research interests:


The bulk of my research output has been involved with synthetic organic chemistry and specifically with the preparation of mycolic acid derivatives, which are found as complex mixtures in the cell walls of bacteria, most notably the TB causing Mycobacterium tuberculosis. As a result of overseeing the first total synthesis of each of the major classes of these mycolic acids, I have been involved in multiple collaborations seeking to exploit these compounds in diagnostic tests or as adjuvants. This work has led to multiple publications and several patents. I have also been involved in the development of efficient routes to the synthesis of cyclopropenes, including cyclopropene fatty acids, which has led to collaborations with research groups investigating their biological activity. I am also involved in the extraction of bioactive components from plants with two current ongoing projects in the area, one as part of the Beacon+ project.

 

Collaborations:

I have been a partner in 6 international collaborations related to the application of molecules we have made in Bangor to the development of new vaccines for treatment of tuberculosis and asthma (Belgium (2), Croatia, Germany, South Korea and South Africa), and in the UK (Southampton, Animal and Public Health Authority). 

  1. Erthygl › Ymchwil › Adolygwyd gan gymheiriaid
  2. Cyhoeddwyd

    1,1,2 Tribromocyclopropanecarboxylic Acid and Derivatives Valuable Intermediates for Four Carbon Cyclopropane and Cyclopropene Synthons

    Al-Dulayymi, A., Al-Dulayymi, J., Baird, M., Gerrard, M. E., Koza, G., Harkins, S. & Roberts, E., 1996, Yn : Tetrahedron. 52, t. 3409

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  3. Cyhoeddwyd

    2 Vinyl 1 1,1,2 trihalocyclopropanes Valuable Five Carbon Cyclopropane and Cyclopropene Synthetic Intermediates

    Al-Dulayymi, A., Al-Dulayymi, J. & Baird, M., 1996, Yn : Tetrahedron. 52, 33, t. 10955

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  4. Cyhoeddwyd

    A nine carbon homologating system for skip-conjugated polyenes

    Mustafa, H. H., Baird, M. S., Al-Dulayymi, J. R. & Tverezovskiy, V., Hyd 2014, Yn : Chemistry and Physics of Lipids. 183, t. 34-42

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  5. Cyhoeddwyd

    Accumulation of 2-aminophenoxazin-3-one-7-carboxylate during growth of Pseudomonas putida TW3 on 4-nitro-substituted substrates requires 4-hydroxylaminobenzoate lyase (PnbB)

    Hughes, M., Baggs, M. J., Al-Dulayymi, J., Baird, M. & Williams, P. A., 1 Hyd 2002, Yn : Applied and Environmental Microbiology. 68, 10, t. 4965-4970

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  6. Cyhoeddwyd

    Arabino mycolates from synthetic mycolic acids

    Mohammed, M. O., Baird, M., Al-Dulayymi, J., Jones, A. & Gwenin, C., 2 Meh 2016, Yn : Tetrahedron. 72, 22, t. 2849-2857

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  7. Cyhoeddwyd

    CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains

    Chancellor, A., Tocheva, A. S., Cave-Ayland, C., Tezera, L., White, A., Al-Dulayymi, J., Bridgeman, J. S., Tews, I., Williams, S., Lissin, N. M., Tebruegge, M., Marshall, B., Sharpe, S., Elliott, T., Skylaris, C-K., Essex, J. W., Baird, M., Gadola, S., Elkington, P. & Mansour, S., 19 Rhag 2017, Yn : PNAS. 114, 51, t. E10956-E10964

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  8. Cyhoeddwyd

    Diastereomeric cyclic tris-allenes

    Mustafa, H., Baird, M., Al-Dulayymi, J. & Tverezovskiy, S., 28 Maw 2013, Yn : Chemical Communications. 2013, 25, t. 2497-2499

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  9. Cyhoeddwyd

    Effective and selective mild catalytic hydrodehalogenation of halocyclopropanes: Preparative capabilities and mechanistic aspects

    Nizovtsev, A. V., Al-Dulayymi, J., Baird, M. S., Bolesov, I. G. & Tverezovsky, V. V., 1 Maw 2003, Yn : Kinetics and Catalysis. 44, 2, t. 151-164

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  10. Cyhoeddwyd

    Flexible Route to [4.1.1] Propellanes

    Al-Dulayymi, A., Al-Dulayymi, J. & Baird, M., Chwef 2000, Yn : Tetrahedron. 56, 8, t. 1115-1125

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  11. Cyhoeddwyd

    Flexible Route to [4.1.1] Propellanes

    Al-Dulayymi, A., Al-Dulayymi, J. & Baird, M., 1997, Yn : Tetrahedron Letters. 38, 38, t. 6755-6758

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  12. Cyhoeddwyd

    Generation and trapping of 1,2 dibromo 3 methyl but 2 en 1 ylidenes

    Al-Dulayymi, A., Al-Dulayymi, J., Baird, M. & Rajaram, L., 24 Gorff 1995, Yn : Tetrahedron. 51, 30, t. 8371-8382

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  13. Cyhoeddwyd

    Glucose monomycolates based on single synthetic mycolic acids

    Sahb, M. M., Al-Dulayymi, J. R. & Baird, M. S., Medi 2015, Yn : Chemistry and Physics of Lipids. 190, t. 9-14

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  14. Cyhoeddwyd

    Glycerol mycolates from synthetic mycolic acids

    Ali, O. T., Sahb, M. M., Al-Dulayymi, J. & Baird, M., 7 Awst 2017, Yn : Carbohydrate Research. 448, t. 67-73

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  15. Cyhoeddwyd

    Hydrodehalogenation of 1,1-dibromocyclopropanes by Grignard reagents promoted by titanium compounds

    Al Dulayymi, JR., Baird, MS., Bolesov, IG., Nizovtsev, AV. & Tverezovsky, VV., 2000, Yn : JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2. 7, t. 1603-1617 15 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  16. Cyhoeddwyd

    Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis

    Tima, H. G., Al-Dulayymi, J., Denis, O., Lehebel, P., Baols, K., Mohammed, M., L'Homme, L., Sahb, M., Potemberg, G., Legrand, S., Lang, R., Beyaert, R., Piette, J., Baird, M. & Hugyen, K., Maw 2017, Yn : Journal of Innate Immunity. 9, 2, t. 162-180 18 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  17. Cyhoeddwyd

    Molecular structure of the Mycobacterium tuberculosis virulence factor, mycolic acid, determines the elicited inflammatory pattern.

    Vander Beken, S., Al-Dulayymi, J., Naessens, T., Koza, G., Maza Iglesias, M., Schubert-Rowles, R., Theunissen, C., De Medts, J., Lanckacker, E., Baird, M. S. & Grooten, J., 1 Chwef 2011, Yn : European Journal of Immunology. 41, 2, t. 450-460

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  18. Cyhoeddwyd

    Mycobacterium tuberculosis-associated synthetic mycolates differentially exert immune stimulatory adjuvant activity

    Smet, M., Pollard, C., De Beuckelaer, A., Van Hoecke, L., Beken, S. V., De Koker, S., Al-Dulayymi, J. R., Huygen, K., Verschoor, J., Baird, M. & Grooten, J., 7 Medi 2016, Yn : European Journal of Immunology. 46, t. 2149-2154 6 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  19. Cyhoeddwyd

    Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages

    Vermeulen, I., Baird, M., Al-Dulayymi, J., Smet, M., Verschoor, J. & Grooten, J., 1 Ebr 2017, Yn : Journal of Lipid Research. 58, 4, t. 709-718 9 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  20. Cyhoeddwyd

    Mycolyl arabino glycerols from synthetic mycolic acids

    Mohammed, M. O., Baird, M. S. & Al-Dulayymi, J., 16 Ion 2015, Yn : Tetrahedron Letters. 56, 23, t. 3268–3272

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  21. Cyhoeddwyd

    New synthetic lipid antigens for rapid serological diagnosis of tuberculosis

    Jones, A., Pitts, M., Al-Dulayymi, J., Gibbons, J., Ramsay, A., Goletti, D., Gwenin, C. & Baird, M., 14 Awst 2017, Yn : PLoS ONE. 12, 8, e0181414.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  22. Cyhoeddwyd

    Preparation of the tri-arabino di-mycolate fragment of mycobacterial arabinogalactan from defined synthetic mycolic acids

    Mohammed, M. O., Baird, M. & Al-Dulayymi, J. R., 2 Ion 2017, Yn : Carbohydrate Research. 437, January, t. 36-42

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  23. Cyhoeddwyd

    Salicylate 5-hydroxylase from Ralstonia sp strain U2: a monoowygenase with close relationships to and shared electron transport proteins with naphthalene dioxygenase

    Zhou, N., Al-Dulayymi, J., Baird, M. & Williams, P. A., 1 Maw 2002, Yn : Journal of Bacteriology. 184, 6, t. 1547-1555

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  24. Cyhoeddwyd

    Standardization of natural mycolic acid antigen composition and production for use in biomarker antibody detection to diagnose active tuberculosis

    Ndlanda, F. L., Ejoh, V., Stoltz, A. C., Naicker, B., Cromarty, A. D., van Wyngaardt, S., Khati, M., Rotherham, L. S., Lemmer, Y., Niebuhr, J., Baumeister, C. R., Al-Dulayymi, J., Swai, H., Baird, M. & Verschoor, J. A., Awst 2016, Yn : Journal of Immunological Methods. 435, t. 50-59 9 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  25. Cyhoeddwyd

    Sterculic Acid and Its Analogues Are Potent Inhibitors of Toxoplasma gondii

    Hao, P., Alaraj, I. Q. M., Al-Dulayymi, J. R., Baird, M., Liu, J. & Liu, Q., 2016, Yn : Korean Journal of Parasitology. 54, 2, t. 139-145 6 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  26. Cyhoeddwyd

    Structure-function relationships of the antigenicity of mycolic acids in tuberculosis patients (vol 163, pg 800, 2010)

    Beukes, M., Lemmer, Y., Deysel, M., Al Dulayymi, J. R., Baird, M. S., Koza, G., Iglesias, M. M., Rowles, R. R., Theunissen, C., Grooten, J., Toschi, G., Roberts, V. V., Pilcher, L., Van Wyngaardt, S., Mathebula, N., Balogun, M., Stoltz, A. C. & Verschoor, J. A., 1 Chwef 2011, Yn : Chemistry and Physics of Lipids. 164, 2, t. 175 1 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  27. Cyhoeddwyd

    Structure-function relationships of the antigenicity of mycolic acids in tuberculosis patients.

    Beukes, M., Lemmer, Y., Deysel, M., Al-Dulayymi, J., Baird, M. S., Koza, G., Maza Iglesias, M., Schubert-Rowles, R., Theunissen, C., Grooten, J., Toschi, G., Roberts, V. V., Pilcher, L., Van Wyngaardt, S., Mathebula, N., Balogun, M., Stoltz, A. C. & Verschoor, J., 1 Tach 2010, Yn : Chemistry and Physics of Lipids. 163, 8, t. 800-808

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  28. Cyhoeddwyd

    Synthesis and properties of methyl 5-(1' R,2 ' S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega- 19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids

    Coxon, G. D., Al-Dulayymi, J., Morehouse, C., Brennan, P. J., Besra, G. S., Baird, M. S. & Minnikin, D. E., 1 Ion 2004, Yn : Chemistry and Physics of Lipids. 127, 1, t. 35-46

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  29. Cyhoeddwyd

    Synthesis of wax esters and related trehalose esters from Mycobacterium avium and other mycobacteria

    Taher, S., Al-Dulayymi, J. R., Tima, H. G., Ali, H. M., Romano, M. & Baird, M., 7 Gorff 2016, Yn : Tetrahedron. 72, 27-28, t. 3863-3876 13 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  30. Cyhoeddwyd

    Synthetic epoxy-mycolic acids

    Kremawi, D. Z., Al-Dulayymi, J. R. & Baird, M. S., 7 Hyd 2014, Yn : Tetrahedron. 70, 40, t. 7322-7335

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  31. Cyhoeddwyd

    Synthetic trehalose di- and mono-esters of alpha-, methoxy- and keto-mycolic acids

    Al-Dulayymi, J. R., Baird, M. S., Maza-Iglesias, M., Hameed, R. T., Baols, K. S., Muzael, M. & Saleh, A. D., 30 Rhag 2014, Yn : Tetrahedron. 70, 52, t. 9836–9852

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  32. Cyhoeddwyd

    Synthetic trehalose esters of cis-alkene and diene α′-mycolic acids of Mycobacteria

    Taher, S. G., Muzael, M. H., Al-Dulayymi, J. R. & Baird, M. S., Gorff 2015, Yn : Chemistry and Physics of Lipids. 189, t. 28-38

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  33. Cyhoeddwyd

    Tandem rearrangements of a cyclic bis-allene

    Mustafa, H. H., Baird, M. S., Al-Dulayymi, J. R. & Tverezovskiy, V., 18 Chwef 2014, Yn : Tetrahedron. 70, 7, t. 1502-1507

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  34. Cyhoeddwyd

    The Synthesis of Mycobacterial Dimycoloyl Diarabinoglycerol Based on Defined Synthetic Mycolic Acids

    Ali, O. T., Mohammed, M., Gates, P. J., Baird, M. & Al-Dulayymi, J., Gorff 2019, Yn : Chemistry and Physics of Lipids. 221, July, t. 207-218

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  35. Cyhoeddwyd

    The Synthesis of Single Enantiomers of α-Mycolic Acids of Mycobacterium tuberculosis and Related Organisms, with Alternative Cyclopropane Stereochemistries

    Don Lawson, C., Maza-Iglesias, M., Baird, M., Sirhan, M. & Al-Dulayymi, J., 31 Mai 2017, Yn : SynOpen.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  36. Cyhoeddwyd

    The absolute stereochemistry of grenadamide.

    Al-Dulayymi, J., Baird, M. S. & Jones, K., 5 Ion 2004, Yn : Tetrahedron. 60, 2, t. 341-345

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  37. Cyhoeddwyd

    The antigenicity and cholesteroid nature of mycolic acids determined by recombinant chicken antibodies

    Ranchod, H., Ndlanda, F. L., Lemmer, Y., Beukes, M., Niebuhr, J., Al-Dulayymi, J., Wemmer, S., Fehrsen, J., Baird, M. & Verschoor, J. A., 9 Awst 2018, Yn : PLoS ONE. 13, 8

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  38. Cyhoeddwyd

    The cycloaddition of cyclopropenes to enones

    Al Dulayymi, JR., Baird, MS., Hussain, HH., Alhourani, BJ., Alhabashna, AMY., Coles, SJ. & Hursthouse, MB., 29 Mai 2000, Yn : Tetrahedron Letters. 41, 21, t. 4205-4208 4 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  39. Cyhoeddwyd

    The first syntheses of single enantiomers of the major methoxymycolic acid of Mycobacterium tuberculosis

    Al-Dulayymi, J., Baird, M. S., Roberts, E., Deysel, M. & Verschoor, J., 19 Maw 2007, Yn : Tetrahedron. 63, 12, t. 2571-2592

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  40. Cyhoeddwyd

    The first synthesis of epoxy-mycolic acids.

    Al Kremawi, D. Z., Al-Dulayymi, J. & Baird, M. S., 1 Maw 2010, Yn : Tetrahedron Letters. 51, 13, t. 1698-1701

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  41. Cyhoeddwyd

    The first unique synthetic mycobacterial cord factors.

    Al-Dulayymi, J., Baird, M. S., Maza Iglesias, M., Vander Beken, S. & Grooten, J., 1 Gorff 2009, Yn : Tetrahedron Letters. 50, 26, t. 3702-3705

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  42. Cyhoeddwyd

    The synthesis of (11R,12S)-lactobacillic acid and its enantionmer.

    Coxon, G. D., Al-Dulayymi, J., Baird, M. S., Knobl, S., Roberts, E. & Minnikin, D. E., 2 Mai 2003, Yn : Tetrahedron Asymmetry. 14, 9, t. 1211-1222

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  43. Cyhoeddwyd

    The synthesis of a major α′-mycolic acid of Mycobacterium smegmatis.

    Muzael, M., Koza, G., Al-Dulayymi, J. & Baird, M. S., 1 Medi 2010, Yn : Chemistry and Physics of Lipids. 163, 7, t. 678-684

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  44. Cyhoeddwyd

    The synthesis of a single enantiomer of a major a-mycolic acid of Mycobacterium tuberculosis

    Al-Dulayymi, J., Baird, M. S. & Roberts, E., 1 Ion 2003, Yn : Chemical Communications. 2, t. 228-229

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  45. Cyhoeddwyd

    The synthesis of a single enantiomer of a major α-mycolic acid of M. tuberculosis

    Al-Dulayymi, J., Baird, M. S. & Roberts, E., 12 Rhag 2005, Yn : Tetrahedron. 61, 50, t. 11939-11951

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  46. Cyhoeddwyd

    The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues.

    Coxon, GD., Knobl, S., Roberts, E., Baird, MS., Al Dulayymi, JR., Besra, GS., Brennan, PJ. & Minnikin, DE., 3 Medi 1999, Yn : Tetrahedron Letters. 40, 36, t. 6689-6692 4 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  47. Cyhoeddwyd

    The synthesis of methoxy and keto mycolic acids containing methyl-trans-cyclopropanes

    Koza, G., Muzael, M., Schubert-Rowles, R. R., Theunissen, C., Al-Dulayymi, J. & Baird, M. S., 29 Gorff 2013, Yn : Tetrahedron. 69, 30, t. 6285-6296

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  48. Cyhoeddwyd

    The synthesis of one enantiomer of the α-methyl-trans-cyclopropane unit of mycolic acids

    Al-Dulayymi, J., Baird, M., Mohammed, H., Roberts, E. & Clegg, W., 15 Mai 2006, Yn : Tetrahedron. 62, 20, t. 4851-4862

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  49. Cyhoeddwyd

    The synthesis of single enantiomers of a meromycolic acid

    Al Dulayymi, JR., Baird, MS. & Roberts, E., 2 Medi 2000, Yn : Tetrahedron Letters. 41, 36, t. 7107-7110 4 t.

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  50. Cyhoeddwyd

    The synthesis of single enantiomers of meromycolic acids from mycobacterial wax esters

    Al-Dulayymi, J., Baird, M. S., Roberts, E. & Minnikin, D. E., 18 Rhag 2006, Yn : Tetrahedron. 62, 51, t. 11867-11880

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

  51. Cyhoeddwyd

    The synthesis of single enantiomers of mycobacterial ketomycolic acids containing cis-cyclopropanes.

    Koza, G., Theunissen, C., Al-Dulayymi, J. & Baird, M. S., 5 Rhag 2009, Yn : Tetrahedron. 65, 49, t. 10214-10229

    Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl

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