The application of data analytical approaches to understand long-term stability trends of organic photovoltaics (OPVs) is presented. Nearly 1900 OPV data points have been catalogued, and multivariate analysis has been applied in order to identify patterns, produce models that quantitatively compare different internal and external stress factors, and subsequently enable predictions of OPV stability to be achieved. Analysis of the weights associated with the acquired predictive model shows that for light stability (ISOS-L) testing, the most significant factor for increasing the time taken to reach 80% of the initial performance (T80
) is the substrate and top electrode selection, and the best light stability is achieved with a small molecule active layer. The weights for damp-heat (ISOS-D) testing shows that the type of encapsulation is the primary factor affecting the degradation to T80. The use of data analytics and potentially machine learning can provide researchers in this area new insights into degradation patterns and emerging trends.