Dr Juma'a Al-Dulayymi

Senior Research Fellow & Lab Support

Contact info

e-mail: chs00c@bangor.ac.uk

 

telephone: 01248 388121

 

Summary of my research interests:


The bulk of my research output has been involved with synthetic organic chemistry and specifically with the preparation of mycolic acid derivatives, which are found as complex mixtures in the cell walls of bacteria, most notably the TB causing Mycobacterium tuberculosis. As a result of overseeing the first total synthesis of each of the major classes of these mycolic acids, I have been involved in multiple collaborations seeking to exploit these compounds in diagnostic tests or as adjuvants. This work has led to multiple publications and several patents. I have also been involved in the development of efficient routes to the synthesis of cyclopropenes, including cyclopropene fatty acids, which has led to collaborations with research groups investigating their biological activity. I am also involved in the extraction of bioactive components from plants with two current ongoing projects in the area, one as part of the Beacon+ project.

 

Collaborations:

I have been a partner in 6 international collaborations related to the application of molecules we have made in Bangor to the development of new vaccines for treatment of tuberculosis and asthma (Belgium (2), Croatia, Germany, South Korea and South Africa), and in the UK (Southampton, Animal and Public Health Authority). 

  1. Article › Research › Peer-reviewed
  2. Published

    1,1,2 Tribromocyclopropanecarboxylic Acid and Derivatives Valuable Intermediates for Four Carbon Cyclopropane and Cyclopropene Synthons

    Al-Dulayymi, A., Al-Dulayymi, J., Baird, M., Gerrard, M. E., Koza, G., Harkins, S. & Roberts, E., 1996, In : Tetrahedron. 52, p. 3409

    Research output: Contribution to journalArticle

  3. Published

    2 Vinyl 1 1,1,2 trihalocyclopropanes Valuable Five Carbon Cyclopropane and Cyclopropene Synthetic Intermediates

    Al-Dulayymi, A., Al-Dulayymi, J. & Baird, M., 1996, In : Tetrahedron. 52, 33, p. 10955

    Research output: Contribution to journalArticle

  4. Published

    A nine carbon homologating system for skip-conjugated polyenes

    Mustafa, H. H., Baird, M. S., Al-Dulayymi, J. R. & Tverezovskiy, V., Oct 2014, In : Chemistry and Physics of Lipids. 183, p. 34-42

    Research output: Contribution to journalArticle

  5. Published

    Accumulation of 2-aminophenoxazin-3-one-7-carboxylate during growth of Pseudomonas putida TW3 on 4-nitro-substituted substrates requires 4-hydroxylaminobenzoate lyase (PnbB)

    Hughes, M., Baggs, M. J., Al-Dulayymi, J., Baird, M. & Williams, P. A., 1 Oct 2002, In : Applied and Environmental Microbiology. 68, 10, p. 4965-4970

    Research output: Contribution to journalArticle

  6. Published

    Arabino mycolates from synthetic mycolic acids

    Mohammed, M. O., Baird, M., Al-Dulayymi, J., Jones, A. & Gwenin, C., 2 Jun 2016, In : Tetrahedron. 72, 22, p. 2849-2857

    Research output: Contribution to journalArticle

  7. Published

    CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains

    Chancellor, A., Tocheva, A. S., Cave-Ayland, C., Tezera, L., White, A., Al-Dulayymi, J., Bridgeman, J. S., Tews, I., Williams, S., Lissin, N. M., Tebruegge, M., Marshall, B., Sharpe, S., Elliott, T., Skylaris, C-K., Essex, J. W., Baird, M., Gadola, S., Elkington, P. & Mansour, S., 19 Dec 2017, In : PNAS. 114, 51, p. E10956-E10964

    Research output: Contribution to journalArticle

  8. Published

    Diastereomeric cyclic tris-allenes

    Mustafa, H., Baird, M., Al-Dulayymi, J. & Tverezovskiy, S., 28 Mar 2013, In : Chemical Communications. 2013, 25, p. 2497-2499

    Research output: Contribution to journalArticle

  9. Published

    Effective and selective mild catalytic hydrodehalogenation of halocyclopropanes: Preparative capabilities and mechanistic aspects

    Nizovtsev, A. V., Al-Dulayymi, J., Baird, M. S., Bolesov, I. G. & Tverezovsky, V. V., 1 Mar 2003, In : Kinetics and Catalysis. 44, 2, p. 151-164

    Research output: Contribution to journalArticle

  10. Published

    Flexible Route to [4.1.1] Propellanes

    Al-Dulayymi, A., Al-Dulayymi, J. & Baird, M., Feb 2000, In : Tetrahedron. 56, 8, p. 1115-1125

    Research output: Contribution to journalArticle

  11. Published

    Flexible Route to [4.1.1] Propellanes

    Al-Dulayymi, A., Al-Dulayymi, J. & Baird, M., 1997, In : Tetrahedron Letters. 38, 38, p. 6755-6758

    Research output: Contribution to journalArticle

  12. Published

    Generation and trapping of 1,2 dibromo 3 methyl but 2 en 1 ylidenes

    Al-Dulayymi, A., Al-Dulayymi, J., Baird, M. & Rajaram, L., 24 Jul 1995, In : Tetrahedron. 51, 30, p. 8371-8382

    Research output: Contribution to journalArticle

  13. Published

    Glucose monomycolates based on single synthetic mycolic acids

    Sahb, M. M., Al-Dulayymi, J. R. & Baird, M. S., Sep 2015, In : Chemistry and Physics of Lipids. 190, p. 9-14

    Research output: Contribution to journalArticle

  14. Published

    Glycerol mycolates from synthetic mycolic acids

    Ali, O. T., Sahb, M. M., Al-Dulayymi, J. & Baird, M., 7 Aug 2017, In : Carbohydrate Research. 448, p. 67-73

    Research output: Contribution to journalArticle

  15. Published

    Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis

    Tima, H. G., Al-Dulayymi, J., Denis, O., Lehebel, P., Baols, K., Mohammed, M., L'Homme, L., Sahb, M., Potemberg, G., Legrand, S., Lang, R., Beyaert, R., Piette, J., Baird, M. & Hugyen, K., Mar 2017, In : Journal of Innate Immunity. 9, 2, p. 162-180 18 p.

    Research output: Contribution to journalArticle

  16. Published

    Molecular structure of the Mycobacterium tuberculosis virulence factor, mycolic acid, determines the elicited inflammatory pattern.

    Vander Beken, S., Al-Dulayymi, J., Naessens, T., Koza, G., Maza Iglesias, M., Schubert-Rowles, R., Theunissen, C., De Medts, J., Lanckacker, E., Baird, M. S. & Grooten, J., 1 Feb 2011, In : European Journal of Immunology. 41, 2, p. 450-460

    Research output: Contribution to journalArticle

  17. Published

    Mycobacterium tuberculosis-associated synthetic mycolates differentially exert immune stimulatory adjuvant activity

    Smet, M., Pollard, C., De Beuckelaer, A., Van Hoecke, L., Beken, S. V., De Koker, S., Al-Dulayymi, J. R., Huygen, K., Verschoor, J., Baird, M. & Grooten, J., 7 Sep 2016, In : European Journal of Immunology. 46, p. 2149-2154 6 p.

    Research output: Contribution to journalArticle

  18. Published

    Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages

    Vermeulen, I., Baird, M., Al-Dulayymi, J., Smet, M., Verschoor, J. & Grooten, J., 1 Apr 2017, In : Journal of Lipid Research. 58, 4, p. 709-718 9 p.

    Research output: Contribution to journalArticle

  19. Published

    Mycolyl arabino glycerols from synthetic mycolic acids

    Mohammed, M. O., Baird, M. S. & Al-Dulayymi, J., 16 Jan 2015, In : Tetrahedron Letters. 56, 23, p. 3268–3272

    Research output: Contribution to journalArticle

  20. Published

    New synthetic lipid antigens for rapid serological diagnosis of tuberculosis

    Jones, A., Pitts, M., Al-Dulayymi, J., Gibbons, J., Ramsay, A., Goletti, D., Gwenin, C. & Baird, M., 14 Aug 2017, In : PLoS ONE. 12, 8, e0181414.

    Research output: Contribution to journalArticle

  21. Published

    Preparation of the tri-arabino di-mycolate fragment of mycobacterial arabinogalactan from defined synthetic mycolic acids

    Mohammed, M. O., Baird, M. & Al-Dulayymi, J. R., 2 Jan 2017, In : Carbohydrate Research. 437, January, p. 36-42

    Research output: Contribution to journalArticle

  22. Published

    Salicylate 5-hydroxylase from Ralstonia sp strain U2: a monoowygenase with close relationships to and shared electron transport proteins with naphthalene dioxygenase

    Zhou, N., Al-Dulayymi, J., Baird, M. & Williams, P. A., 1 Mar 2002, In : Journal of Bacteriology. 184, 6, p. 1547-1555

    Research output: Contribution to journalArticle

  23. Published

    Standardization of natural mycolic acid antigen composition and production for use in biomarker antibody detection to diagnose active tuberculosis

    Ndlanda, F. L., Ejoh, V., Stoltz, A. C., Naicker, B., Cromarty, A. D., van Wyngaardt, S., Khati, M., Rotherham, L. S., Lemmer, Y., Niebuhr, J., Baumeister, C. R., Al-Dulayymi, J., Swai, H., Baird, M. & Verschoor, J. A., Aug 2016, In : Journal of Immunological Methods. 435, p. 50-59 9 p.

    Research output: Contribution to journalArticle

  24. Published

    Sterculic Acid and Its Analogues Are Potent Inhibitors of Toxoplasma gondii

    Hao, P., Alaraj, I. Q. M., Al-Dulayymi, J. R., Baird, M., Liu, J. & Liu, Q., 2016, In : Korean Journal of Parasitology. 54, 2, p. 139-145 6 p.

    Research output: Contribution to journalArticle

  25. Published

    Structure-function relationships of the antigenicity of mycolic acids in tuberculosis patients.

    Beukes, M., Lemmer, Y., Deysel, M., Al-Dulayymi, J., Baird, M. S., Koza, G., Maza Iglesias, M., Schubert-Rowles, R., Theunissen, C., Grooten, J., Toschi, G., Roberts, V. V., Pilcher, L., Van Wyngaardt, S., Mathebula, N., Balogun, M., Stoltz, A. C. & Verschoor, J., 1 Nov 2010, In : Chemistry and Physics of Lipids. 163, 8, p. 800-808

    Research output: Contribution to journalArticle

  26. Published

    Synthesis and properties of methyl 5-(1' R,2 ' S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega- 19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids

    Coxon, G. D., Al-Dulayymi, J., Morehouse, C., Brennan, P. J., Besra, G. S., Baird, M. S. & Minnikin, D. E., 1 Jan 2004, In : Chemistry and Physics of Lipids. 127, 1, p. 35-46

    Research output: Contribution to journalArticle

  27. Published

    Synthesis of wax esters and related trehalose esters from Mycobacterium avium and other mycobacteria

    Taher, S., Al-Dulayymi, J. R., Tima, H. G., Ali, H. M., Romano, M. & Baird, M., 7 Jul 2016, In : Tetrahedron. 72, 27-28, p. 3863-3876 13 p.

    Research output: Contribution to journalArticle

  28. Published

    Synthetic epoxy-mycolic acids

    Kremawi, D. Z., Al-Dulayymi, J. R. & Baird, M. S., 7 Oct 2014, In : Tetrahedron. 70, 40, p. 7322-7335

    Research output: Contribution to journalArticle

  29. Published

    Synthetic trehalose di- and mono-esters of alpha-, methoxy- and keto-mycolic acids

    Al-Dulayymi, J. R., Baird, M. S., Maza-Iglesias, M., Hameed, R. T., Baols, K. S., Muzael, M. & Saleh, A. D., 30 Dec 2014, In : Tetrahedron. 70, 52, p. 9836–9852

    Research output: Contribution to journalArticle

  30. Published

    Synthetic trehalose esters of cis-alkene and diene α′-mycolic acids of Mycobacteria

    Taher, S. G., Muzael, M. H., Al-Dulayymi, J. R. & Baird, M. S., Jul 2015, In : Chemistry and Physics of Lipids. 189, p. 28-38

    Research output: Contribution to journalArticle

  31. Published

    Tandem rearrangements of a cyclic bis-allene

    Mustafa, H. H., Baird, M. S., Al-Dulayymi, J. R. & Tverezovskiy, V., 18 Feb 2014, In : Tetrahedron. 70, 7, p. 1502-1507

    Research output: Contribution to journalArticle

  32. Published

    The Synthesis of Mycobacterial Dimycoloyl Diarabinoglycerol Based on Defined Synthetic Mycolic Acids

    Ali, O. T., Mohammed, M., Gates, P. J., Baird, M. & Al-Dulayymi, J., Jul 2019, In : Chemistry and Physics of Lipids. 221, July, p. 207-218

    Research output: Contribution to journalArticle

  33. Published

    The Synthesis of Single Enantiomers of α-Mycolic Acids of Mycobacterium tuberculosis and Related Organisms, with Alternative Cyclopropane Stereochemistries

    Don Lawson, C., Maza-Iglesias, M., Baird, M., Sirhan, M. & Al-Dulayymi, J., 31 May 2017, In : SynOpen.

    Research output: Contribution to journalArticle

  34. Published

    The absolute stereochemistry of grenadamide.

    Al-Dulayymi, J., Baird, M. S. & Jones, K., 5 Jan 2004, In : Tetrahedron. 60, 2, p. 341-345

    Research output: Contribution to journalArticle

  35. Published

    The antigenicity and cholesteroid nature of mycolic acids determined by recombinant chicken antibodies

    Ranchod, H., Ndlanda, F. L., Lemmer, Y., Beukes, M., Niebuhr, J., Al-Dulayymi, J., Wemmer, S., Fehrsen, J., Baird, M. & Verschoor, J. A., 9 Aug 2018, In : PLoS ONE. 13, 8

    Research output: Contribution to journalArticle

  36. Published

    The first syntheses of single enantiomers of the major methoxymycolic acid of Mycobacterium tuberculosis

    Al-Dulayymi, J., Baird, M. S., Roberts, E., Deysel, M. & Verschoor, J., 19 Mar 2007, In : Tetrahedron. 63, 12, p. 2571-2592

    Research output: Contribution to journalArticle

  37. Published

    The first synthesis of epoxy-mycolic acids.

    Al Kremawi, D. Z., Al-Dulayymi, J. & Baird, M. S., 1 Mar 2010, In : Tetrahedron Letters. 51, 13, p. 1698-1701

    Research output: Contribution to journalArticle

  38. Published

    The first unique synthetic mycobacterial cord factors.

    Al-Dulayymi, J., Baird, M. S., Maza Iglesias, M., Vander Beken, S. & Grooten, J., 1 Jul 2009, In : Tetrahedron Letters. 50, 26, p. 3702-3705

    Research output: Contribution to journalArticle

  39. Published

    The synthesis of (11R,12S)-lactobacillic acid and its enantionmer.

    Coxon, G. D., Al-Dulayymi, J., Baird, M. S., Knobl, S., Roberts, E. & Minnikin, D. E., 2 May 2003, In : Tetrahedron Asymmetry. 14, 9, p. 1211-1222

    Research output: Contribution to journalArticle

  40. Published

    The synthesis of a major α′-mycolic acid of Mycobacterium smegmatis.

    Muzael, M., Koza, G., Al-Dulayymi, J. & Baird, M. S., 1 Sep 2010, In : Chemistry and Physics of Lipids. 163, 7, p. 678-684

    Research output: Contribution to journalArticle

  41. Published

    The synthesis of a single enantiomer of a major a-mycolic acid of Mycobacterium tuberculosis

    Al-Dulayymi, J., Baird, M. S. & Roberts, E., 1 Jan 2003, In : Chemical Communications. 2, p. 228-229

    Research output: Contribution to journalArticle

  42. Published

    The synthesis of a single enantiomer of a major α-mycolic acid of M. tuberculosis

    Al-Dulayymi, J., Baird, M. S. & Roberts, E., 12 Dec 2005, In : Tetrahedron. 61, 50, p. 11939-11951

    Research output: Contribution to journalArticle

  43. Published

    The synthesis of methoxy and keto mycolic acids containing methyl-trans-cyclopropanes

    Koza, G., Muzael, M., Schubert-Rowles, R. R., Theunissen, C., Al-Dulayymi, J. & Baird, M. S., 29 Jul 2013, In : Tetrahedron. 69, 30, p. 6285-6296

    Research output: Contribution to journalArticle

  44. Published

    The synthesis of one enantiomer of the α-methyl-trans-cyclopropane unit of mycolic acids

    Al-Dulayymi, J., Baird, M., Mohammed, H., Roberts, E. & Clegg, W., 15 May 2006, In : Tetrahedron. 62, 20, p. 4851-4862

    Research output: Contribution to journalArticle

  45. Published

    The synthesis of single enantiomers of meromycolic acids from mycobacterial wax esters

    Al-Dulayymi, J., Baird, M. S., Roberts, E. & Minnikin, D. E., 18 Dec 2006, In : Tetrahedron. 62, 51, p. 11867-11880

    Research output: Contribution to journalArticle

  46. Published

    The synthesis of single enantiomers of mycobacterial ketomycolic acids containing cis-cyclopropanes.

    Koza, G., Theunissen, C., Al-Dulayymi, J. & Baird, M. S., 5 Dec 2009, In : Tetrahedron. 65, 49, p. 10214-10229

    Research output: Contribution to journalArticle

  47. Published

    The synthesis of single enantiomers of trans-alkene containing mycolic acids and related sugar esters

    Ali, H., Koza, G., Hameed, R., Rowles, R., Davies, C., Al-Dulayymi, J. R., Gwenin, C. & Baird, M., 10 Nov 2016, In : Tetrahedron. 72, 45, p. 7143-7158 15 p.

    Research output: Contribution to journalArticle

  48. Published

    The synthesis of single enantiomers of trans-alkene-containing mycolic acids

    Koza, G., Schubert-Rowles, R., Theunissen, C., Al-Dulayymi, J. & Baird, M. S., 30 Dec 2009, In : Tetrahedron Letters. 50, 52, p. 7259-7262

    Research output: Contribution to journalArticle

  49. Published

    The synthesis of single enantiomers of α-mycolic acids of M.tuberculosis with alternative cyclopropane stereochemistries

    Don Lawson, C., Maza-Iglesias, M., Sirhan, M. M., Al-Dulayymi, J. & Baird, M., 2017, In : SynOpen. 01, 01, p. 0103-0116 13 p.

    Research output: Contribution to journalArticle

  50. Published

    Thiol modified mycolic acids

    Balogun, M. O., Huws, E. H., Sirhan, M. M., Saleh, A. D., Al Dulayymi, J. R., Pilcher, L., Verschoor, J. A. & Baird, M. S., Jul 2013, In : Chemistry and Physics of Lipids. 172-173, July-August, p. 40-57 16 p.

    Research output: Contribution to journalArticle

  51. Patent › Research
  52. Published

    Adjuvants for Use in Vaccination

    Baird, M., Al-Dulayymi, J., Theunissen, C., Koza, G., Beken, S. V. & Grooten, J., 2011, Patent No. 20110142916

    Research output: Patent

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