Dr Martina Lahmann
Honorary Lecturer
Affiliations
Contact info
Martina Lahmann is working at the Organic Chemistry/Life Science interface (Chemical Biology). Her expertise is in organic synthesis, carbohydrate and glycoconjugate chemistry.
Martina received her diploma in Chemistry at the University of Hamburg, Germany, in 1994. She continued her work in the group of Prof. Joachim Thiem and obtained her Ph.D. in Organic Chemistry in 1997. Thereafter she moved to Stockholm University, Sweden, to work as a postdoc with Prof. Per J. Garegg and Prof. Stefan Oscarson. In 2002 she moved to Göteborg University, Sweden, to supervise the part of Stefan’s group which was relocated to Göteborg University, to lecture Organic Chemistry, and then to develop her independent research. In September 2005 she received the Docent degree in Organic Chemistry from Göteborg University. After a year in the Arrhenius Laboratory at Stockholm University, focussing on her research, Martina joined us at Bangor in September 2007.
The major focus on her current research comprises the development of new tools and structures for the identification and analysis of carbohydrate recognition domains, directing to a deeper understanding of carbohydrate-protein interactions on the molecular level, which eventually allows a more rational design and development of carbohydrate-based pharmaceuticals. Adhesion of bacteria to human glycoconjugate receptors is a crucial step in the development of many diseases and is often mediated by carbohydrate-protein interactions. As model system, she focuses on the binding of Helicobacter pylori (collaborators S. Oscarson, University College Dublin, and T. Borén, University of Umeå) which induces chronic inflammation by attaching itself to carbohydrate structures in the stomach lining. Another bacterial target is the uropathogenic Escherichia coli (UPEC), accounting for more than 80 % of urinary tract infections. To inhibit the adhesion of bacteria to the bladder is proposed to be an alternative approach to challenge antibiotic resistance. Transferred to the lab-bench this spans from “plain” oligosaccharide synthesis (e.g. Lewis-blood group structures), variously tagged carbohydrate structures (e.g. photolabeling, selenoglycosides) to designed conjugates (e.g. glycocluster, dendrimers).
The exploration of glycosylation reactions, e.g. solvent dependency, and the development of protecting group- and conjugation techniques represents another research-area.
- Article › Research › Peer-reviewed
- Published
A Soluble Fucose-Specific Lectin from Aspergillus fumigatus Conidia - Structure, Specificity and Possible Role in Fungal Pathogenicity
Houser, J., Komarek, J., Kostlanova, N., Cioci, G., Varrot, A., Kerr, S. C., Lahmann, M., Balloy, V., Fahy, J. F., Chignard, M., Imberty, A. & Wimmerova, M., 10 Dec 2013, In: PLoS ONE.Research output: Contribution to journal › Article › peer-review
- Published
A TNF-like trimeric lectin domain from Burkholdeda cenocepacia with specificity for fucosylated human histo-blood group antigens.
Šulák, O., Delia, M., Lahmann, M., Varrot, A., Imberty, A. & Wimmerová, M., 13 Jan 2010, In: Structure. 18, 1, p. 59-72Research output: Contribution to journal › Article › peer-review
- Published
A facile approach to diosgenin and furostan type saponins bearing a 3 beta-chacotriose moiety
Lahmann, M., Gyback, H., Garegg, P. J., Oscarson, S., Suhr, R. & Thiem, J., 19 Nov 2002, In: Carbohydrate Research. 337, 21-23, p. 2153-2159Research output: Contribution to journal › Article › peer-review
- Published
An investigation of the antileishmanial properties of semi-synthetic saponins
Anderson, O., Beckett, J., Briggs, C. C., Natrass, L. A., Cranston, C. F., Wilkinson, E. J., Owen, J., Williams, R. M., Loukaidis, A., Bouillon, M., Pritchard, D., Lahmann, M., Baird, M. & Denny, P. W., 1 Jul 2020, In: Medicinal Chemistry. 11, 7, p. 833-842Research output: Contribution to journal › Article › peer-review
- Published
Antiprotozoal effect of saponins in the rumen can be enhanced by chemical modifications in their structure
Ramos-Morales, E., De La Fuente, G., Duval, S., Wehrli, C., Bouillon, M., Lahmann, M., Preskett, D., Braganca, R. & Newbold, J., 16 Mar 2017, In: Frontiers in Microbiology. 8, 399.Research output: Contribution to journal › Article › peer-review
- Published
Architecture and Evolution of Blade Assembly in β-propeller Lectins
Bonnardel, F., Kumar, A., Wimmerova, M., Lahmann, M., Perez, S., Varrot, A., Lisacek, F. & Imberty, A., 7 May 2019, In: Structure. 27, 5, p. 764-775Research output: Contribution to journal › Article › peer-review
- Published
Architectures of Multivalent Glycomimetics for Probing Carbohydrate–Lectin Interactions.
Lahmann, M., 1 Jan 2009, In: Topics in Current Chemistry. 288, p. 17-65Research output: Contribution to journal › Article › peer-review
- Published
Atomic mapping of the sugar interactions in one-site and two-site mutants of Cyanovirin-N by NMR spectroscopy
Sandstrom, C., Hakkarainen, B., Matei, E., Glinchert, A., Lahmann, M., Oscarson, S., Kenne, L. & Gronenborn, A. M., 25 Mar 2008, In: Biochemistry. 47, 12, p. 3625-3635Research output: Contribution to journal › Article › peer-review
- Published
Block synthesis of Streptococcus pneumoniae type 14 capsular polysaccharide structures
Sundgren, A., Lahmann, M. & Oscarson, S., 1 May 2005, In: Journal of Carbohydrate Chemistry. 24, 4-6, p. 379-391Research output: Contribution to journal › Article › peer-review
- Published
Design and synthesis of HIV-1 protease inhibitors. Novel tetrahydrofuran P2/P2 '-groups interacting with Asp29/30 of the HIV-1 protease. Determination of binding from X-ray crystal structure of inhibitor protease complex
Oscarsson, K., Lahmann, M., Lindberg, J., Kangasmetsa, J., Unge, T., Oscarson, S., Hallberg, A. & Samuelsson, B., 20 Mar 2003, In: Bioorganic and Medicinal Chemistry. 11, 6, p. 1107-1115Research output: Contribution to journal › Article › peer-review
- Published
Ethyl 2-acetamido-4,6-di-O-benzyl-2,3-N,O-carbonyl-2-deoxy-1-thio-beta-glycopyranoside as a versatile GlcNAc donor
Boysen, M., Gemma, E., Lahmann, M. & Oscarson, S., 1 Jan 2005, In: Chemical Communications. 24, p. 3044-3046Research output: Contribution to journal › Article › peer-review
- Published
Functional adaptation of BabA, the H-pylori ABO blood group antigen binding adhesion
Aspholm-Hurtig, M., Dailide, G., Lahmann, M., Kalia, A., Ilver, D., Roche, N., Vikstrom, S., Sjostrom, R., Linden, S., Backstrom, A., Lundberg, C., Arnqvist, A., Mahdavi, J., Nilsson, U. J., Velapatino, B., Gilman, R. H., Gerhard, M., Alarcon, T., Lopez-Brea, M., Nakazawa, T., Fox, J. G., Correa, P., Dominguez-Bello, M. G., Perez-Perez, G. I., Blaser, M. J., Normark, S., Carlstedt, I., Oscarson, S., Teneberg, S., Berg, D. E. & Boren, T., 1 Jul 2004, In: Science. 305, 5683, p. 519-522Research output: Contribution to journal › Article › peer-review
- Published
Glycocluster design for improved avidity and selectivity in blocking human lectin/plant toxin binding to glycoproteins and cells.
Andre, S., Lahmann, M., Gabius, H. J. & Oscarson, S., 6 Dec 2010, In: Molecular Pharmaceutics. 7, 6, p. 2270-2279Research output: Contribution to journal › Article › peer-review
- Published
Gold nanoparticles as carriers for a synthetic Streptococcus pneumoniae type 14 conjugate vaccine
Safari, D., Marradi, M., Chiodo, F., Dekker, H. A., Shan, Y., Adamo, R., Oscarson, S., Rijkers, G. T., Lahmann, M., Kamerling, J. P., Penadés, S. & Snippe, H., 1 May 2012, In: Nanomedicine. 7, 5, p. 651-662Research output: Contribution to journal › Article › peer-review
- Published
Identification of the smallest structure capable of evoking opsonophagocytic antibodies against Streptococcus pneumoniae type 14
Safari, D., Dekker, H. A. T., Joosten, J. A. F., Michalik, D., de Souza, A. C., Adamo, R., Lahmann, M., Sundgren, A., Oscarson, S., Kamerling, J. P. & Snippe, H., Oct 2008, In: Infection and Immunity. 76, 10, p. 4615-4623Research output: Contribution to journal › Article › peer-review
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Impact of natural variation in bacterial F17G adhesins on crystallization behaviour
Buts, L., Wellens, A., Van Molle, I., Wyns, L., Loris, R., Lahmann, M., Oscarson, S., de Greve, H. & Bouckaert, J., 1 Aug 2005, In: Acta Crystallographica Section D: Biological Crystallography. 61, 8, p. 1149-1159Research output: Contribution to journal › Article › peer-review
- Published
Improving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure
Ramos-Morales, E., de la Fuente, G., Nash, R. J., Braganca, R., Duval, S., Bouillon, M., Lahmann, M. & Newbold, J., 8 Sept 2017, In: PLoS ONE. 12, 9, e0184517.Research output: Contribution to journal › Article › peer-review
- Published
Investigation of the reactivity difference between thioglycoside donors with variant aglycon parts
Lahmann, M. & Oscarson, S., 1 Aug 2002, In: Canadian Journal of Chemistry. 80, 8, p. 889-893Research output: Contribution to journal › Article › peer-review
- Published
Investigations of glycosylation reactions with 2-N-acetyl-2N,3O-oxazolidinone-protected glucosamine donors.
Olsson, J. D., Eriksson, L., Lahmann, M. & Oscarson, S., 19 Sept 2008, In: Journal of Organic Chemistry. 73, 18, p. 7181-7188Research output: Contribution to journal › Article › peer-review
- Published
Isolation and characterisation of 13 pterosins and pterosides from bracken (Pteridium aquilinum (L.) Kuhn) rhizome
Mohammad, R., Nur-e-Alam, M., Lahmann, M., Parveen, I., Tizzard, G. J., Coles, S. J., Fowler, M., Drake, A. F., Heyes, D. & Thoss, V., Aug 2016, In: Phytochemistry. 128, p. 82-94Research output: Contribution to journal › Article › peer-review
- Published
Lactosamine from lactulose via the Heyns rearrangement: a practical protocol
Shan, Y., Oulaidi Lamiable, F. & Lahmann, M., 24 Jul 2013, In: Tetrahedron Letters. 54, 30, p. 3960-3961Research output: Contribution to journal › Article › peer-review
- Published
Ligands of the asialoglycoprotein receptor for targeted gene delivery, part 1: Synthesis of and binding studies with biotinylated cluster glycosides containing N-acetylgalactosamine
Westerlind, U., Westman, J., Tornquist, E., Smith, C. I., Oscarson, S., Lahmann, M. & Norberg, T., 1 Jan 2004, In: Glycoconjugate Journal. 21, 5, p. 227-241Research output: Contribution to journal › Article › peer-review
- Published
Multivalent glycoconjugates as anti-pathogenic agents
Bernardi, A., Jimenez-Barbero, J., Casnati, A., De Castro, C., Darbre, T., Fieschi, F., Finne, J., Funken, H., Jaeger, K-E., Lahmann, M., Lindhorst, T. K., Marradi, M., Messner, P., Molinaro, A., Murphy, P. V., Nativi, C., Oscarson, S., Penades, S., Peri, F., Pieters, R. J., Renaudet, O., Reymond, J-L., Richichi, B., Rojo, J., Sansone, F., Schaeffer, C., Turnbull, W. B., Velasco-Torrijos, T., Vidal, S., Vincent, S., Wennekes, T., Zuilhof, H. & Imberty, A., 2013, In: Chemical Society Reviews. 42, 11, p. 4709-4727Research output: Contribution to journal › Article › peer-review
- Published
NMR study of hydroxy protons of di- and trimannosides, substructures of Man-9
Hakkarainen, B., Kenne, L., Lahmann, M., Oscarson, S. & Sandstrom, C., 1 Dec 2007, In: Magnetic Resonance in Chemistry. 45, 12, p. 1076-1080Research output: Contribution to journal › Article › peer-review
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One-pot oligosaccharide synthesis exploiting solvent reactivity effects
Lahmann, M. & Oscarson, S., 30 Nov 2000, In: Organic Letters. 2, 24, p. 3881-3882Research output: Contribution to journal › Article › peer-review
- Published
Preparation and immunogenicity of gold glyco-nanoparticles as antipneumococcal vaccine model
Vetro, M., Safari, D., Fallarini, S., Salsabila, K., Lahmann, M., Penades, S., Lay, L., Marradi, M. & Compostella, F., Jan 2017, In: Nanomedicine. 12, 1Research output: Contribution to journal › Article › peer-review
- Published
Reversible non-covalent derivatisation of carbon nanotubes with glycosides.
Andersson, C. H., Lahmann, M., Oscarson, S. & Grennberg, H., 1 Jan 2009, In: Soft Matter. 5, 14, p. 2713-2716Research output: Contribution to journal › Article › peer-review
- Published
SmI2/water/amine mediates cleavage of allyl ether protected alcohols: Application in carbohydrate synthesis and mechanistic considerations
Dahlen, A., Sundgren, A., Lahmann, M., Oscarson, S. & Hilmersson, G., 30 Oct 2003, In: Organic Letters. 5, 22, p. 4085-4088Research output: Contribution to journal › Article › peer-review
- Published
Solving the phase problem for carbohydrate-binding proteins using selenium derivatives of their ligands: a case study involving the bacterial F17-G adhesin
Buts, L., Loris, R., De Genst, E., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L., De Greve, H. & Bouckaert, J., 1 Jun 2003, In: Acta Crystallographica Section D: Biological Crystallography. 59, 6, p. 1012-1015Research output: Contribution to journal › Article › peer-review
- Published
Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori
Moonens, K., Gideonsson, P., Subedi, S., Bugaytsova, J., Romaõ, E., Mendez, M., Nordén, J., Fallah, M., Rakhimova, L., Shevtsova, A., Lahmann, M., Castaldo, G., Brännström, K., Coppens, F., Lo, A. W., Ny, T., Solnick, J. V., Vandenbussche, G., Oscarson, S., Hammarström, L., Arnqvist, A., Berg, D. E., Muyldermans, S., Borén, T. & Remaut, H., 13 Jan 2016, In: Cell Host and Microbe. 19, 1, p. 55-66Research output: Contribution to journal › Article › peer-review
- Published
Synthesis of 6-PEtN-α-D-GalpNAc-(1–>6)-β-D-Galp-(1–>4)-β-D-GlcpNAc-(1–>3)-β-D-Galp-(1–>4)-β-D-Glcp, a Haemophilus influenzae lipopolysacharide structure, and biotin and protein conjugates thereof.
Sundgren, A., Lahmann, M. & Oscarson, S., 26 Jul 2010, In: Beilstein Journal of Organic Chemistry. 6, p. 704-708Research output: Contribution to journal › Article › peer-review
- Published
Synthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium
Bouillon, M., Bertocco, K., Bischoff, L., Buri, M., Davies, L. R., Wilkinson, E. J. & Lahmann, M., 31 Dec 2020, In: European Journal of Organic Chemistry. 2020, 48, p. 7470-7473Research output: Contribution to journal › Article › peer-review
- Published
Synthesis of Type 1 Lewis b hexasaccharide antigen structures featuring flexible incorporation of L-[U-13C6]-fucose for NMR binding studies
Long, M., Ni Cheallaigh, A., Reihill, M., Oscarson, S. & Lahmann, M., 21 Jun 2020, In: Organic and Biomolecular Chemistry. 18, 23, p. 4452-4458Research output: Contribution to journal › Article › peer-review
- Published
Synthesis of a polyphosphorylated GPI-anchor core structure.
Lahmann, M., Garegg, P. J., Konradsson, P. & Oscarson, S., 1 Aug 2002, In: Canadian Journal of Chemistry. 80, 8, p. 1105-1111Research output: Contribution to journal › Article › peer-review
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Synthesis of alpha-tocopheryl oligosaccharides
Lahmann, M. & Thiem, J., 26 Mar 1997, In: Carbohydrate Research. 299, 1-2, p. 23-31Research output: Contribution to journal › Article › peer-review
- Published
Synthesis of dihydrodiosgenin glycosides as mimetics of bidesmosidic steroidal saponins
Suhr, R., Lahmann, M., Oscarson, S. & Thiem, J., 17 Oct 2003, In: European Journal of Organic Chemistry. 20, p. 4003-4011Research output: Contribution to journal › Article › peer-review
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Synthesis of monodeoxy analogues of the trisaccharide alpha-D-Glcp-(1 -> 3)-alpha-D-Manp-(1 -> 2)-alpha-D-ManpOMe recognised by calreticulin/calnexin
Gemma, E., Lahmann, M. & Oscarson, S., 24 Jul 2006, In: Carbohydrate Research. 341, 10, p. 1533-1542Research output: Contribution to journal › Article › peer-review
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Synthesis of oligosaccharides corresponding to Vibrio cholerae O139 polysaccharide structures containing dideoxy sugars and a cyclic phosphate
Turek, D., Sundgren, A., Lahmann, M. & Oscarson, S., 1 Jan 2006, In: Organic and Biomolecular Chemistry. 4, 7, p. 1236-1241Research output: Contribution to journal › Article › peer-review
- Published
Synthesis of the Lewis b hexasaccharide and HSA-conjugates thereof.
Lahmann, M., Bulow, L., Teodorovic, P., Gyback, H. & Oscarson, S., 1 Sept 2004, In: Glycoconjugate Journal. 21, 5, p. 251-256Research output: Contribution to journal › Article › peer-review
- Published
Synthesis of the Lewis b pentasaccharide and a HAS-conjugate thereof.
Fourniere, V., Skantz, L., Sajtos, F., Oscarson, S. & Lahmann, M., 22 Jul 2010, In: Tetrahedron.Research output: Contribution to journal › Article › peer-review
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Synthesis of the tetrasaccharide alpha-D-Glcp(1 -> 3)-alpha-D-Manp-(1 -> 2)-alpha-D-Manp-(1 -> 2)-alpha-D-Manp recognized by calreticulin/calnexin
Gemma, E., Lahmann, M. & Oscarson, S., 21 Nov 2005, In: Carbohydrate Research. 340, 16, p. 2558-2562Research output: Contribution to journal › Article › peer-review
- Published
Synthesis of urine drug metabolites: glucuranosyl esters of carboxymefloquine, indoprofen, (S)-naproxen and desmethyl (S)-naproxen
Lahmann, M., Bergstrom, M. A., Turek, D. & Oscarson, S., 1 Dec 2004, In: Journal of Carbohydrate Chemistry. 23, 2, p. 123-132Research output: Contribution to journal › Article › peer-review
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Synthesis of urine drug metabolites: glucuronic acid glycosides of phenol intermediates
Arewang, C. J., Lahmann, M., Oscarson, S. & Tiden, A. K., 21 May 2007, In: Carbohydrate Research. 342, 7, p. 970-974Research output: Contribution to journal › Article › peer-review
- Published
The Tyrosine Gate as a Potential Entropic Lever in the Receptor-Binding Site of the Bacterial Adhesin FimH
Wellens, A., Lahmann, M., Touaibiall, M., Vaucher, J., Oscarson, S., Roy, R., Ramaut, H. & Bouckaert, J., 2012, In: Biochemistry. 51, 24, p. 4790-4799Research output: Contribution to journal › Article › peer-review
- Published
The fimbrial adhesin F17-G of enterotoxigenic Escherichia coli has an immunoglobulin-like lectin domain that binds N-acetylglucosamine
Buts, L., Bouckaert, J., De Genst, E., Loris, R., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L. & De Greve, H., 1 Aug 2003, In: Molecular Microbiology. 49, 3, p. 705-715Research output: Contribution to journal › Article › peer-review
- Published
The fucose-binding lectin from Ralstonia solanacearum - A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan
Kostlanova, N., Mitchell, E. P., Lortat-Jacob, H., Oscarson, S., Lahmann, M., Gilboa-Garber, N., Chambat, G., Wimmerova, M. & Imberty, A., 29 Jul 2005, In: Journal of Biological Chemistry. 280, 30, p. 27839-27849Research output: Contribution to journal › Article › peer-review
- Published
Transformations of chromanol and tocopherol and synthesis of ascorbate conjugates
Lahmann, M. & Thiem, J., 4 Mar 2011, In: Tetrahedron. 67, 9, p. 1654-1664Research output: Contribution to journal › Article › peer-review
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beta-propeller crystal structure of Psathyrella velutina lectin: An integrin-like fungal protein interacting
Cioci, G., Mitchell, E. P., Chazalet, V., Debray, H., Oscarson, S., Lahmann, M., Gautier, C., Breton, C., Perez, S. & Imberty, A., 14 Apr 2006, In: Journal of Molecular Biology. 357, 5, p. 1575-1591Research output: Contribution to journal › Article › peer-review
- Chapter › Research › Not peer-reviewed
- Published
Stereoselective Reduction Using Sodium Triacetoxyborodeuteride: Synthesis of Methyl 2,3-Di-O-benzyl-α-d-(4-2H)-glucopyranoside
Mobarak, H., Engstrom, O., Lahmann, M., Widmalm, G., Roy, R. (ed.) & Vidal, S. (ed.), 27 May 2015, Carbohydrate Chemistry: Proven Synthetic Methods: Volume 3. 2015 ed. CRC Press, p. 81-88Research output: Chapter in Book/Report/Conference proceeding › Chapter
- Chapter › Research › Peer-reviewed
- Published
Sakurai Anomeric Allylation of Methyl α-Pyranosides
Bouillon, M., Williams, R. M., Lahmann, M. & McCabe, O., Jan 2021, Carbohydrate chemistry: Proven synthetic methods. Kosma, P., Wrodnigg, T. M. & Stutz, A. (eds.). Boca Raton: CRC Press, Vol. 5. p. 55-63Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review