Validation of a Noninvasive Assessment of Pulmonary Gas Exchange During Exercise in Hypoxia

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  • Connor Howe
    University of British Columbia, Okanagan
  • David MacLeod
    Duke University
  • Liisa Wainman
    University of British Columbia, Vancouver
  • Sam Oliver
  • Philip Ainslie
    University of British Columbia, Okanagan
Pulmonary gas exchange efficiency, determined by the alveolar-to-arterial P o 2 difference (A-aD o 2), progressively worsens during exercise at sea-level; this response is further elevated during exercise in hypoxia. Traditionally, pulmonary gas exchange efficiency is assessed through measurements of ventilation and end-tidal gases paired with direct arterial blood gas (ABG) sampling. Because these measures have a number of caveats, particularly invasive blood sampling, the development of new approaches for the noninvasive assessment of pulmonary gas exchange is needed.

Keywords

  • exercise, hypoxia, noninvasive, pulmonary gas exchange, validation
Original languageEnglish
Pages (from-to)1644-1650
JournalChest
Volume158
Issue number4
Early online date25 Apr 2020
DOIs
Publication statusPublished - 1 Oct 2020

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