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/P 1805 0 R
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/S /Span
>>
endobj
146 0 obj
<<
/ActualText (4)
/K 99
/P 1805 0 R
/Pg 38 0 R
/S /Span
>>
endobj
147 0 obj
<<
/ActualText
/K 100
/P 1806 0 R
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>>
endobj
148 0 obj
<<
/ActualText
/K 101
/P 1807 0 R
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>>
endobj
149 0 obj
<<
/ActualText (mec1)
/K 102
/P 1807 0 R
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>>
endobj
150 0 obj
<<
/ActualText (-)
/K 103
/P 1807 0 R
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>>
endobj
151 0 obj
<<
/ActualText (4)
/K 104
/P 1807 0 R
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>>
endobj
152 0 obj
<<
/K 105
/P 1614 0 R
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/S /Figure
>>
endobj
153 0 obj
<<
/K 106
/P 1614 0 R
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/S /Figure
>>
endobj
154 0 obj
<<
/K 107
/P 1614 0 R
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/S /Figure
>>
endobj
155 0 obj
<<
/K 108
/P 1614 0 R
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/S /Figure
>>
endobj
156 0 obj
<<
/ActualText (Known )
/K 109
/P 1808 0 R
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>>
endobj
157 0 obj
<<
/ActualText (\(n=208\))
/K 110
/P 1808 0 R
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>>
endobj
158 0 obj
<<
/ActualText (163)
/K 111
/P 1809 0 R
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>>
endobj
159 0 obj
<<
/ActualText (\(78%\))
/K 112
/P 1810 0 R
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>>
endobj
160 0 obj
<<
/ActualText (39)
/K 113
/P 1811 0 R
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>>
endobj
161 0 obj
<<
/ActualText (361)
/K 114
/P 1812 0 R
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>>
endobj
162 0 obj
<<
/ActualText (\(90%\))
/K 115
/P 1813 0 R
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>>
endobj
163 0 obj
<<
/ActualText (SGA )
/K 116
/P 1814 0 R
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>>
endobj
164 0 obj
<<
/ActualText (\(n=400\))
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endobj
165 0 obj
<<
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>>
endobj
166 0 obj
<<
/K 119
/P 1614 0 R
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>>
endobj
167 0 obj
<<
/K 120
/P 1614 0 R
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>>
endobj
168 0 obj
<<
/K 121
/P 1614 0 R
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>>
endobj
169 0 obj
<<
/K 122
/P 1614 0 R
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>>
endobj
170 0 obj
<<
/K 123
/P 1614 0 R
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>>
endobj
171 0 obj
<<
/ActualText
/K 124
/P 1815 0 R
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>>
endobj
172 0 obj
<<
/ActualText
/K 125
/P 1816 0 R
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>>
endobj
173 0 obj
<<
/ActualText (mec1)
/K 126
/P 1816 0 R
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>>
endobj
174 0 obj
<<
/ActualText (-)
/K 127
/P 1816 0 R
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>>
endobj
175 0 obj
<<
/ActualText (4)
/K 128
/P 1816 0 R
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>>
endobj
176 0 obj
<<
/K 129
/P 1614 0 R
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>>
endobj
177 0 obj
<<
/ActualText (Figure 1. Synthetic Genetic Array \(SGA\) analysis of )
/K 130
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>>
endobj
178 0 obj
<<
/ActualText (mec1)
/K 131
/P 1817 0 R
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>>
endobj
179 0 obj
<<
/ActualText (-)
/K 132
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>>
endobj
180 0 obj
<<
/ActualText (4 )
/K 133
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endobj
181 0 obj
<<
/ActualText (identifies novel genetic )
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endobj
182 0 obj
<<
/ActualText (interactors involved in )
/K 135
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endobj
183 0 obj
<<
/ActualText (proteostasis)
/K 136
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>>
endobj
184 0 obj
<<
/ActualText (.)
/K 137
/P 1817 0 R
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>>
endobj
185 0 obj
<<
/ActualText (A.)
/K 138
/P 1818 0 R
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>>
endobj
186 0 obj
<<
/ActualText (Limited)
/K 139
/P 1818 0 R
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>>
endobj
187 0 obj
<<
/ActualText (overlap)
/K 140
/P 1818 0 R
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>>
endobj
188 0 obj
<<
/ActualText (between)
/K 141
/P 1818 0 R
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>>
endobj
189 0 obj
<<
/ActualText (SGA)
/K 142
/P 1818 0 R
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>>
endobj
190 0 obj
<<
/ActualText (hits)
/K 143
/P 1818 0 R
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>>
endobj
191 0 obj
<<
/ActualText
/K 144
/P 1818 0 R
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>>
endobj
192 0 obj
<<
/ActualText (\(Figure)
/K 145
/P 1818 0 R
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>>
endobj
193 0 obj
<<
/ActualText (S1;)
/K 146
/P 1818 0 R
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>>
endobj
194 0 obj
<<
/ActualText (Table)
/K 147
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endobj
195 0 obj
<<
/ActualText (S1\))
/K 148
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>>
endobj
196 0 obj
<<
/ActualText (and)
/K 149
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endobj
197 0 obj
<<
/ActualText (208)
/K 150
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>>
endobj
198 0 obj
<<
/ActualText (previously )
/K 151
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>>
endobj
199 0 obj
<<
/ActualText (reported genetic/physical interactors of Mec1/)
/K 152
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/S /Span
>>
endobj
200 0 obj
<<
/ActualText (MEC1 )
/K 153
/P 1818 0 R
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>>
endobj
201 0 obj
<<
/ActualText
/K 154
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>>
endobj
202 0 obj
<<
/ActualText (. )
/K 155
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endobj
203 0 obj
<<
/ActualText (%: The )
/K 156
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>>
endobj
204 0 obj
<<
/ActualText (percentage of genes unique to either)
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>>
endobj
205 0 obj
<<
/ActualText (set.)
/K 158
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>>
endobj
206 0 obj
<<
/ActualText (B.)
/K 159
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>>
endobj
207 0 obj
<<
/ActualText (Upper panel: GO \(Gene Ontology\) terms enriched in the 39 genes common to both)
/K 160
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>>
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208 0 obj
<<
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/K 161
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>>
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209 0 obj
<<
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>>
endobj
210 0 obj
<<
/ActualText (FunSpec)
/K 163
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>>
endobj
211 0 obj
<<
/ActualText (\(Robinson et )
/K 164
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>>
endobj
212 0 obj
<<
/ActualText (al., 2002\).)
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>>
endobj
213 0 obj
<<
/ActualText (C.)
/K 166
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>>
endobj
214 0 obj
<<
/ActualText (Indicated strains were spotted on YPD and incubated at the indicated temperatures. )
/K 167
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>>
endobj
215 0 obj
<<
/ActualText (Blue or red: synthetic positive)
/K 168
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>>
endobj
216 0 obj
<<
/ActualText (-)
/K 169
/P 1820 0 R
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>>
endobj
217 0 obj
<<
/ActualText (or negative)
/K 170
/P 1820 0 R
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>>
endobj
218 0 obj
<<
/ActualText (-)
/K 171
/P 1820 0 R
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>>
endobj
219 0 obj
<<
/ActualText (interaction with )
/K 172
/P 1820 0 R
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>>
endobj
220 0 obj
<<
/ActualText (mec1)
/K 173
/P 1820 0 R
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>>
endobj
221 0 obj
<<
/ActualText (-)
/K 174
/P 1820 0 R
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>>
endobj
222 0 obj
<<
/ActualText (4)
/K 175
/P 1820 0 R
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>>
endobj
223 0 obj
<<
/ActualText (,)
/K 176
/P 1820 0 R
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>>
endobj
224 0 obj
<<
/ActualText (respectively.)
/K 177
/P 1820 0 R
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>>
endobj
225 0 obj
<<
/K 0
/P 1615 0 R
/Pg 39 0 R
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>>
endobj
226 0 obj
<<
/ActualText (M)
/K 1
/P 1821 0 R
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>>
endobj
227 0 obj
<<
/ActualText (M)
/K 2
/P 1822 0 R
/Pg 39 0 R
/S /Span
>>
endobj
228 0 obj
<<
/K 3
/P 1615 0 R
/Pg 39 0 R
/S /Figure
>>
endobj
229 0 obj
<<
/ActualText (30)
/K 4
/P 1823 0 R
/Pg 39 0 R
/S /Span
>>
endobj
230 0 obj
<<
/ActualText (o)
/K 5
/P 1823 0 R
/Pg 39 0 R
/S /Span
>>
endobj
231 0 obj
<<
/ActualText (C)
/K 6
/P 1823 0 R
/Pg 39 0 R
/S /Span
>>
endobj
232 0 obj
<<
/ActualText (WT )
/K 7
/P 1824 0 R
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/S /Span
>>
endobj
233 0 obj
<<
/ActualText (sml1)
/K 8
/P 1825 0 R
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/S /Span
>>
endobj
234 0 obj
<<
/ActualText (D)
/K 9
/P 1825 0 R
/Pg 39 0 R
/S /Span
>>
endobj
235 0 obj
<<
/ActualText (mec1)
/K 10
/P 1826 0 R
/Pg 39 0 R
/S /Span
>>
endobj
236 0 obj
<<
/ActualText (-)
/K 11
/P 1826 0 R
/Pg 39 0 R
/S /Span
>>
endobj
237 0 obj
<<
/ActualText (4 )
/K 12
/P 1826 0 R
/Pg 39 0 R
/S /Span
>>
endobj
238 0 obj
<<
/ActualText (sml1)
/K 13
/P 1826 0 R
/Pg 39 0 R
/S /Span
>>
endobj
239 0 obj
<<
/ActualText (D )
/K 14
/P 1826 0 R
/Pg 39 0 R
/S /Span
>>
endobj
240 0 obj
<<
/ActualText (mec1)
/K 15
/P 1827 0 R
/Pg 39 0 R
/S /Span
>>
endobj
241 0 obj
<<
/ActualText (-)
/K 16
/P 1827 0 R
/Pg 39 0 R
/S /Span
>>
endobj
242 0 obj
<<
/ActualText (4)
/K 17
/P 1827 0 R
/Pg 39 0 R
/S /Span
>>
endobj
243 0 obj
<<
/ActualText (L )
/K 18
/P 1828 0 R
/Pg 39 0 R
/S /Span
>>
endobj
244 0 obj
<<
/ActualText (+ )
/K 19
/P 1828 0 R
/Pg 39 0 R
/S /Span
>>
endobj
245 0 obj
<<
/ActualText (-)
/K 20
/P 1828 0 R
/Pg 39 0 R
/S /Span
>>
endobj
246 0 obj
<<
/ActualText (L )
/K 21
/P 1829 0 R
/Pg 39 0 R
/S /Span
>>
endobj
247 0 obj
<<
/ActualText (+ )
/K 22
/P 1829 0 R
/Pg 39 0 R
/S /Span
>>
endobj
248 0 obj
<<
/ActualText (-)
/K 23
/P 1829 0 R
/Pg 39 0 R
/S /Span
>>
endobj
249 0 obj
<<
/ActualText (L )
/K 24
/P 1830 0 R
/Pg 39 0 R
/S /Span
>>
endobj
250 0 obj
<<
/ActualText (+ )
/K 25
/P 1830 0 R
/Pg 39 0 R
/S /Span
>>
endobj
251 0 obj
<<
/ActualText (-)
/K 26
/P 1830 0 R
/Pg 39 0 R
/S /Span
>>
endobj
252 0 obj
<<
/ActualText (L )
/K 27
/P 1831 0 R
/Pg 39 0 R
/S /Span
>>
endobj
253 0 obj
<<
/ActualText (+ )
/K 28
/P 1831 0 R
/Pg 39 0 R
/S /Span
>>
endobj
254 0 obj
<<
/ActualText (-)
/K 29
/P 1831 0 R
/Pg 39 0 R
/S /Span
>>
endobj
255 0 obj
<<
/ActualText (D)
/K 30
/P 1832 0 R
/Pg 39 0 R
/S /Span
>>
endobj
256 0 obj
<<
/K 31
/P 1615 0 R
/Pg 39 0 R
/S /Figure
>>
endobj
257 0 obj
<<
/K 32
/P 1615 0 R
/Pg 39 0 R
/S /Figure
>>
endobj
258 0 obj
<<
/K 33
/P 1615 0 R
/Pg 39 0 R
/S /Figure
>>
endobj
259 0 obj
<<
/K 34
/P 1615 0 R
/Pg 39 0 R
/S /Figure
>>
endobj
260 0 obj
<<
/ActualText (33)
/K 35
/P 1833 0 R
/Pg 39 0 R
/S /Span
>>
endobj
261 0 obj
<<
/ActualText (o)
/K 36
/P 1833 0 R
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/S /Span
>>
endobj
262 0 obj
<<
/ActualText (C)
/K 37
/P 1833 0 R
/Pg 39 0 R
/S /Span
>>
endobj
263 0 obj
<<
/ActualText (E)
/K 38
/P 1834 0 R
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>>
endobj
264 0 obj
<<
/ActualText (WT )
/K 39
/P 1835 0 R
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/S /Span
>>
endobj
265 0 obj
<<
/ActualText (sml1)
/K 40
/P 1836 0 R
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/S /Span
>>
endobj
266 0 obj
<<
/ActualText (D)
/K 41
/P 1836 0 R
/Pg 39 0 R
/S /Span
>>
endobj
267 0 obj
<<
/ActualText (mec1)
/K 42
/P 1837 0 R
/Pg 39 0 R
/S /Span
>>
endobj
268 0 obj
<<
/ActualText (-)
/K 43
/P 1837 0 R
/Pg 39 0 R
/S /Span
>>
endobj
269 0 obj
<<
/ActualText (4 )
/K 44
/P 1837 0 R
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/S /Span
>>
endobj
270 0 obj
<<
/ActualText (sml1)
/K 45
/P 1837 0 R
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/S /Span
>>
endobj
271 0 obj
<<
/ActualText (D )
/K 46
/P 1837 0 R
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>>
endobj
272 0 obj
<<
/ActualText (mec1)
/K 47
/P 1838 0 R
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/S /Span
>>
endobj
273 0 obj
<<
/ActualText (-)
/K 48
/P 1838 0 R
/Pg 39 0 R
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>>
endobj
274 0 obj
<<
/ActualText (4)
/K 49
/P 1838 0 R
/Pg 39 0 R
/S /Span
>>
endobj
275 0 obj
<<
/ActualText (L )
/K 50
/P 1839 0 R
/Pg 39 0 R
/S /Span
>>
endobj
276 0 obj
<<
/ActualText (+ )
/K 51
/P 1839 0 R
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>>
endobj
277 0 obj
<<
/ActualText (-)
/K 52
/P 1839 0 R
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>>
endobj
278 0 obj
<<
/ActualText (L )
/K 53
/P 1840 0 R
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>>
endobj
279 0 obj
<<
/ActualText (+ )
/K 54
/P 1840 0 R
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>>
endobj
280 0 obj
<<
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/K 55
/P 1840 0 R
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>>
endobj
281 0 obj
<<
/ActualText (L )
/K 56
/P 1841 0 R
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/S /Span
>>
endobj
282 0 obj
<<
/ActualText (+ )
/K 57
/P 1841 0 R
/Pg 39 0 R
/S /Span
>>
endobj
283 0 obj
<<
/ActualText (-)
/K 58
/P 1841 0 R
/Pg 39 0 R
/S /Span
>>
endobj
284 0 obj
<<
/ActualText (L )
/K 59
/P 1842 0 R
/Pg 39 0 R
/S /Span
>>
endobj
285 0 obj
<<
/ActualText (+ )
/K 60
/P 1842 0 R
/Pg 39 0 R
/S /Span
>>
endobj
286 0 obj
<<
/ActualText (-)
/K 61
/P 1842 0 R
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/S /Span
>>
endobj
287 0 obj
<<
/K 62
/P 1615 0 R
/Pg 39 0 R
/S /Figure
>>
endobj
288 0 obj
<<
/K 63
/P 1615 0 R
/Pg 39 0 R
/S /Figure
>>
endobj
289 0 obj
<<
/K 64
/P 1615 0 R
/Pg 39 0 R
/S /Figure
>>
endobj
290 0 obj
<<
/ActualText (25 )
/K 65
/P 1843 0 R
/Pg 39 0 R
/S /Span
>>
endobj
291 0 obj
<<
/ActualText (o)
/K 66
/P 1843 0 R
/Pg 39 0 R
/S /Span
>>
endobj
292 0 obj
<<
/ActualText (C)
/K 67
/P 1843 0 R
/Pg 39 0 R
/S /Span
>>
endobj
293 0 obj
<<
/ActualText (33 )
/K 68
/P 1844 0 R
/Pg 39 0 R
/S /Span
>>
endobj
294 0 obj
<<
/ActualText (o)
/K 69
/P 1844 0 R
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/S /Span
>>
endobj
295 0 obj
<<
/ActualText (C)
/K 70
/P 1844 0 R
/Pg 39 0 R
/S /Span
>>
endobj
296 0 obj
<<
/ActualText (33 )
/K 71
/P 1845 0 R
/Pg 39 0 R
/S /Span
>>
endobj
297 0 obj
<<
/ActualText (o)
/K 72
/P 1845 0 R
/Pg 39 0 R
/S /Span
>>
endobj
298 0 obj
<<
/ActualText (C)
/K 73
/P 1845 0 R
/Pg 39 0 R
/S /Span
>>
endobj
299 0 obj
<<
/ActualText (Glycerol)
/K 74
/P 1846 0 R
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/S /Span
>>
endobj
300 0 obj
<<
/ActualText (Glucose)
/K 75
/P 1847 0 R
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/S /Span
>>
endobj
301 0 obj
<<
/K 76
/P 1615 0 R
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/S /Figure
>>
endobj
302 0 obj
<<
/K 77
/P 1615 0 R
/Pg 39 0 R
/S /Figure
>>
endobj
303 0 obj
<<
/K 78
/P 1615 0 R
/Pg 39 0 R
/S /Figure
>>
endobj
304 0 obj
<<
/ActualText (WT)
/K 79
/P 1848 0 R
/Pg 39 0 R
/S /Span
>>
endobj
305 0 obj
<<
/ActualText (mec1)
/K 80
/P 1849 0 R
/Pg 39 0 R
/S /Span
>>
endobj
306 0 obj
<<
/ActualText (-)
/K 81
/P 1849 0 R
/Pg 39 0 R
/S /Span
>>
endobj
307 0 obj
<<
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<<
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<<
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<<
/ActualText (o)
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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>>
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<<
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<<
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<<
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<<
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<<
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<<
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<<
/ActualText (Indicated strains were grown overnight at 25)
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
/ActualText (mec1)
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>>
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<<
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<<
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>>
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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>>
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532 0 obj
<<
/ActualText (o)
/K 307
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<<
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<<
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<<
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>>
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<<
/ActualText (Red: )
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>>
endobj
537 0 obj
<<
/ActualText (mec1)
/K 312
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>>
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<<
/ActualText (-)
/K 313
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>>
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<<
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>>
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<<
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>>
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<<
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/K 316
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>>
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542 0 obj
<<
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543 0 obj
<<
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>>
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<<
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>>
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<<
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>>
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<<
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<<
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/K 322
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<<
/ActualText (o)
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>>
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<<
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>>
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<<
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>>
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<<
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>>
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<<
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<<
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>>
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<<
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>>
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<<
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>>
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<<
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>>
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<<
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<<
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>>
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<<
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>>
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<<
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/K 336
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<<
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>>
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<<
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>>
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564 0 obj
<<
/ActualText (Glycerol)
/K 339
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>>
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<<
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/K 340
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>>
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<<
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/K 341
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>>
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<<
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/K 342
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>>
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<<
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/K 343
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>>
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>>
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<<
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>>
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<<
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>>
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<<
/K 0
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>>
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<<
/K 1
/P 1616 0 R
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/S /Figure
>>
endobj
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<<
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>>
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<<
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/K 3
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>>
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<<
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/K 4
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>>
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577 0 obj
<<
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/K 5
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>>
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<<
/K 6
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>>
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<<
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>>
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<<
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>>
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<<
/K 9
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>>
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<<
/K 10
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>>
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<<
/K 11
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>>
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<<
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>>
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<<
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<<
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>>
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<<
/K 15
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>>
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<<
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/K 16
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/S /Span
>>
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<<
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/K 17
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>>
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<<
/ActualText (Htt25QP)
/K 18
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/S /Span
>>
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<<
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/K 19
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>>
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<<
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/K 20
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<<
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/K 21
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>>
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<<
/K 22
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>>
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<<
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>>
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<<
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<<
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>>
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<<
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<<
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<<
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>>
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<<
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>>
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<<
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>>
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<<
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>>
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<<
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>>
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<<
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>>
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<<
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/K 34
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>>
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<<
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<<
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<<
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>>
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<<
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<<
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>>
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<<
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/K 40
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>>
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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<<
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>>
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<<
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<<
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>>
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<<
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/K 56
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>>
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<<
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/K 57
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>>
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<<
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/K 58
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<<
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<<
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<<
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/K 61
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>>
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<<
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/K 62
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>>
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<<
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/K 63
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>>
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<<
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/K 64
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>>
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<<
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/K 65
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>>
endobj
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<<
/ActualText (mec1)
/K 66
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>>
endobj
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/S /Span
>>
endobj
809 0 obj
<<
/ActualText (33)
/K 237
/P 2006 0 R
/Pg 40 0 R
/S /Span
>>
endobj
810 0 obj
<<
/ActualText (o)
/K 238
/P 2006 0 R
/Pg 40 0 R
/S /Span
>>
endobj
811 0 obj
<<
/ActualText (C)
/K 239
/P 2006 0 R
/Pg 40 0 R
/S /Span
>>
endobj
812 0 obj
<<
/K 240
/P 1616 0 R
/Pg 40 0 R
/S /Figure
>>
endobj
813 0 obj
<<
/K 241
/P 1616 0 R
/Pg 40 0 R
/S /Figure
>>
endobj
814 0 obj
<<
/K 242
/P 1616 0 R
/Pg 40 0 R
/S /Figure
>>
endobj
815 0 obj
<<
/K 243
/P 1616 0 R
/Pg 40 0 R
/S /Figure
>>
endobj
816 0 obj
<<
/K 244
/P 1616 0 R
/Pg 40 0 R
/S /Figure
>>
endobj
817 0 obj
<<
/K 245
/P 1616 0 R
/Pg 40 0 R
/S /Figure
>>
endobj
818 0 obj
<<
/K 246
/P 1616 0 R
/Pg 40 0 R
/S /Figure
>>
endobj
819 0 obj
<<
/K 247
/P 1616 0 R
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/S /Figure
>>
endobj
820 0 obj
<<
/K 248
/P 1616 0 R
/Pg 40 0 R
/S /Figure
>>
endobj
821 0 obj
<<
/ActualText (Figure 3. Htt103Q expression is toxic to )
/K 249
/P 2007 0 R
/Pg 40 0 R
/S /Span
>>
endobj
822 0 obj
<<
/ActualText (mec1)
/K 250
/P 2007 0 R
/Pg 40 0 R
/S /Span
>>
endobj
823 0 obj
<<
/ActualText (-)
/K 251
/P 2007 0 R
/Pg 40 0 R
/S /Span
>>
endobj
824 0 obj
<<
/ActualText (4 )
/K 252
/P 2007 0 R
/Pg 40 0 R
/S /Span
>>
endobj
825 0 obj
<<
/ActualText (and )
/K 253
/P 2007 0 R
/Pg 40 0 R
/S /Span
>>
endobj
826 0 obj
<<
/ActualText
/K 254
/P 2007 0 R
/Pg 40 0 R
/S /Span
>>
endobj
827 0 obj
<<
/ActualText (cells)
/K 255
/P 2007 0 R
/Pg 40 0 R
/S /Span
>>
endobj
828 0 obj
<<
/ActualText (.)
/K 256
/P 2007 0 R
/Pg 40 0 R
/S /Span
>>
endobj
829 0 obj
<<
/ActualText (A.)
/K 257
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
830 0 obj
<<
/ActualText (Schematic representation of Huntingtin \()
/K 258
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
831 0 obj
<<
/ActualText (Htt)
/K 259
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
832 0 obj
<<
/ActualText
/K 260
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
833 0 obj
<<
/ActualText (Poly glutamine \(Q\) domain; 25 and 103 indicates the number of Qs in each peptide. )
/K 261
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
834 0 obj
<<
/ActualText
/K 262
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
835 0 obj
<<
/ActualText (proline)
/K 263
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
836 0 obj
<<
/ActualText (domain, implicated in )
/K 264
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
837 0 obj
<<
/ActualText (Htt)
/K 265
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
838 0 obj
<<
/ActualText (aggregation)
/K 266
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
839 0 obj
<<
/ActualText (.)
/K 267
/P 2008 0 R
/Pg 40 0 R
/S /Span
>>
endobj
840 0 obj
<<
/ActualText (B.)
/K 268
/P 2009 0 R
/Pg 40 0 R
/S /Span
>>
endobj
841 0 obj
<<
/ActualText (Representative images of )
/K 269
/P 2009 0 R
/Pg 40 0 R
/S /Span
>>
endobj
842 0 obj
<<
/ActualText (Htt)
/K 270
/P 2009 0 R
/Pg 40 0 R
/S /Span
>>
endobj
843 0 obj
<<
/ActualText (-)
/K 271
/P 2009 0 R
/Pg 40 0 R
/S /Span
>>
endobj
844 0 obj
<<
/ActualText (GFP morphology. Class I: diffuse throughout the cell. )
/K 272
/P 2009 0 R
/Pg 40 0 R
/S /Span
>>
endobj
845 0 obj
<<
/ActualText (Class II: a single large aggregate. Class III: multiple)
/K 273
/P 2009 0 R
/Pg 40 0 R
/S /Span
>>
endobj
846 0 obj
<<
/ActualText (aggregates.)
/K 274
/P 2009 0 R
/Pg 40 0 R
/S /Span
>>
endobj
847 0 obj
<<
/ActualText (C)
/K 275
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
848 0 obj
<<
/ActualText (, D)
/K 276
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
849 0 obj
<<
/ActualText (. )
/K 277
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
850 0 obj
<<
/ActualText (Htt103QP )
/K 278
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
851 0 obj
<<
/ActualText (\()
/K 279
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
852 0 obj
<<
/ActualText (C)
/K 280
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
853 0 obj
<<
/ActualText (\) and Htt103Q \()
/K 281
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
854 0 obj
<<
/ActualText (D)
/K 282
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
855 0 obj
<<
/ActualText (\) morphology in )
/K 283
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
856 0 obj
<<
/ActualText (WT )
/K 284
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
857 0 obj
<<
/ActualText (and )
/K 285
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
858 0 obj
<<
/ActualText (mec1)
/K 286
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
859 0 obj
<<
/ActualText (-)
/K 287
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
860 0 obj
<<
/ActualText (4 )
/K 288
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
861 0 obj
<<
/ActualText (cells following 2 )
/K 289
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
862 0 obj
<<
/ActualText (hour)
/K 290
/P 2010 0 R
/Pg 40 0 R
/S /Span
>>
endobj
863 0 obj
<<
/ActualText (incubation in )
/K 291
/P 2011 0 R
/Pg 40 0 R
/S /Span
>>
endobj
864 0 obj
<<
/ActualText (galactose medium at the indicated temperatures. Grey, red, and blue: )
/K 292
/P 2011 0 R
/Pg 40 0 R
/S /Span
>>
endobj
865 0 obj
<<
/ActualText (% )
/K 293
/P 2012 0 R
/Pg 40 0 R
/S /Span
>>
endobj
866 0 obj
<<
/ActualText (of cells )
/K 294
/P 2012 0 R
/Pg 40 0 R
/S /Span
>>
endobj
867 0 obj
<<
/ActualText (exhibiting Class )
/K 295
/P 2012 0 R
/Pg 40 0 R
/S /Span
>>
endobj
868 0 obj
<<
/ActualText (I, II, or III morphology described in panel )
/K 296
/P 2012 0 R
/Pg 40 0 R
/S /Span
>>
endobj
869 0 obj
<<
/ActualText (B)
/K 297
/P 2012 0 R
/Pg 40 0 R
/S /Span
>>
endobj
870 0 obj
<<
/ActualText (, respectively. )
/K 298
/P 2012 0 R
/Pg 40 0 R
/S /Span
>>
endobj
871 0 obj
<<
/ActualText (Asterisks)
/K 299
/P 2013 0 R
/Pg 40 0 R
/S /Span
>>
endobj
872 0 obj
<<
/ActualText (: statistically )
/K 300
/P 2013 0 R
/Pg 40 0 R
/S /Span
>>
endobj
873 0 obj
<<
/ActualText (significant )
/K 301
/P 2013 0 R
/Pg 40 0 R
/S /Span
>>
endobj
874 0 obj
<<
/ActualText (increase over WT \(p < 0.005\) \(Table S4\).)
/K 302
/P 2013 0 R
/Pg 40 0 R
/S /Span
>>
endobj
875 0 obj
<<
/ActualText (E.)
/K 303
/P 2014 0 R
/Pg 40 0 R
/S /Span
>>
endobj
876 0 obj
<<
/ActualText (Representative Htt103Q morphology in WT and )
/K 304
/P 2014 0 R
/Pg 40 0 R
/S /Span
>>
endobj
877 0 obj
<<
/ActualText (mec1)
/K 305
/P 2014 0 R
/Pg 40 0 R
/S /Span
>>
endobj
878 0 obj
<<
/ActualText (-)
/K 306
/P 2014 0 R
/Pg 40 0 R
/S /Span
>>
endobj
879 0 obj
<<
/ActualText (4 )
/K 307
/P 2014 0 R
/Pg 40 0 R
/S /Span
>>
endobj
880 0 obj
<<
/ActualText (following 2 hour incubation in )
/K 308
/P 2014 0 R
/Pg 40 0 R
/S /Span
>>
endobj
881 0 obj
<<
/ActualText (galactose medium at)
/K 309
/P 2014 0 R
/Pg 40 0 R
/S /Span
>>
endobj
882 0 obj
<<
/ActualText (25)
/K 310
/P 2014 0 R
/Pg 40 0 R
/S /Span
>>
endobj
883 0 obj
<<
/ActualText (o)
/K 311
/P 2014 0 R
/Pg 40 0 R
/S /Span
>>
endobj
884 0 obj
<<
/ActualText (C.)
/K 312
/P 2014 0 R
/Pg 40 0 R
/S /Span
>>
endobj
885 0 obj
<<
/ActualText (F.)
/K 313
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
886 0 obj
<<
/ActualText (mec1)
/K 314
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
887 0 obj
<<
/ActualText (-)
/K 315
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
888 0 obj
<<
/ActualText (4 )
/K 316
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
889 0 obj
<<
/ActualText (and )
/K 317
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
890 0 obj
<<
/ActualText (WT )
/K 318
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
891 0 obj
<<
/ActualText (strains transformed with the indicated )
/K 319
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
892 0 obj
<<
/ActualText (Htt)
/K 320
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
893 0 obj
<<
/ActualText (-)
/K 321
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
894 0 obj
<<
/ActualText (GFP plasmids were spotted )
/K 322
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
895 0 obj
<<
/ActualText (onto a glucose or galactose plate and incubated at 25)
/K 323
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
896 0 obj
<<
/ActualText (o)
/K 324
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
897 0 obj
<<
/ActualText (C. Two independent )
/K 325
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
898 0 obj
<<
/ActualText (transformants)
/K 326
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
899 0 obj
<<
/ActualText (were )
/K 327
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
900 0 obj
<<
/ActualText (analyzed)
/K 328
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
901 0 obj
<<
/ActualText (for each )
/K 329
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
902 0 obj
<<
/ActualText (Htt)
/K 330
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
903 0 obj
<<
/ActualText (peptide.)
/K 331
/P 2015 0 R
/Pg 40 0 R
/S /Span
>>
endobj
904 0 obj
<<
/ActualText (G.)
/K 332
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
905 0 obj
<<
/ActualText (Opposite effects of CHX on )
/K 333
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
906 0 obj
<<
/ActualText (mec1)
/K 334
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
907 0 obj
<<
/ActualText (-)
/K 335
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
908 0 obj
<<
/ActualText (4 )
/K 336
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
909 0 obj
<<
/ActualText (and )
/K 337
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
910 0 obj
<<
/ActualText
/K 338
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
911 0 obj
<<
/ActualText (Red: )
/K 339
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
912 0 obj
<<
/ActualText (mec1)
/K 340
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
913 0 obj
<<
/ActualText (-)
/K 341
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
914 0 obj
<<
/ActualText (4 )
/K 342
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
915 0 obj
<<
/ActualText (confers resistance to CHX. )
/K 343
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
916 0 obj
<<
/ActualText (Blue: )
/K 344
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
917 0 obj
<<
/ActualText
/K 345
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
918 0 obj
<<
/ActualText (confers sensitivity to CHX. Yellow: )
/K 346
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
919 0 obj
<<
/ActualText (mec1)
/K 347
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
920 0 obj
<<
/ActualText (-)
/K 348
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
921 0 obj
<<
/ActualText (4, mec1)
/K 349
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
922 0 obj
<<
/ActualText (-)
/K 350
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
923 0 obj
<<
/ActualText (kd)
/K 351
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
924 0 obj
<<
/ActualText (, and )
/K 352
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
925 0 obj
<<
/ActualText
/K 353
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
926 0 obj
<<
/ActualText (rescue )
/K 354
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
927 0 obj
<<
/ActualText (CHX sensitivity of)
/K 355
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
928 0 obj
<<
/ActualText
/K 356
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
929 0 obj
<<
/ActualText (.)
/K 357
/P 2016 0 R
/Pg 40 0 R
/S /Span
>>
endobj
930 0 obj
<<
/ActualText (H.)
/K 358
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
931 0 obj
<<
/ActualText (Htt103Q is toxic to )
/K 359
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
932 0 obj
<<
/ActualText (mec1)
/K 360
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
933 0 obj
<<
/ActualText (-)
/K 361
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
934 0 obj
<<
/ActualText
/K 362
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
935 0 obj
<<
/ActualText (and )
/K 363
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
936 0 obj
<<
/ActualText (mec1)
/K 364
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
937 0 obj
<<
/ActualText (-)
/K 365
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
938 0 obj
<<
/ActualText
/K 366
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
939 0 obj
<<
/ActualText (at)
/K 367
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
940 0 obj
<<
/ActualText (25)
/K 368
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
941 0 obj
<<
/ActualText (o)
/K 369
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
942 0 obj
<<
/ActualText (C.)
/K 370
/P 2017 0 R
/Pg 40 0 R
/S /Span
>>
endobj
943 0 obj
<<
/K 0
/P 1617 0 R
/Pg 41 0 R
/S /Span
>>
endobj
944 0 obj
<<
/K 1
/P 1617 0 R
/Pg 41 0 R
/S /Figure
>>
endobj
945 0 obj
<<
/K 2
/P 1617 0 R
/Pg 41 0 R
/S /Figure
>>
endobj
946 0 obj
<<
/K 3
/P 1617 0 R
/Pg 41 0 R
/S /Figure
>>
endobj
947 0 obj
<<
/ActualText (a)
/K 4
/P 2018 0 R
/Pg 41 0 R
/S /Span
>>
endobj
948 0 obj
<<
/ActualText (-)
/K 5
/P 2018 0 R
/Pg 41 0 R
/S /Span
>>
endobj
949 0 obj
<<
/ActualText (Sml1)
/K 6
/P 2018 0 R
/Pg 41 0 R
/S /Span
>>
endobj
950 0 obj
<<
/ActualText (Ponc)
/K 7
/P 2019 0 R
/Pg 41 0 R
/S /Span
>>
endobj
951 0 obj
<<
/ActualText (.)
/K 8
/P 2019 0 R
/Pg 41 0 R
/S /Span
>>
endobj
952 0 obj
<<
/K 9
/P 1617 0 R
/Pg 41 0 R
/S /Figure
>>
endobj
953 0 obj
<<
/K 10
/P 1617 0 R
/Pg 41 0 R
/S /Figure
>>
endobj
954 0 obj
<<
/ActualText (YPD)
/K 11
/P 2020 0 R
/Pg 41 0 R
/S /Span
>>
endobj
955 0 obj
<<
/ActualText (MMS )
/K 12
/P 2021 0 R
/Pg 41 0 R
/S /Span
>>
endobj
956 0 obj
<<
/ActualText (G)
/K 13
/P 2022 0 R
/Pg 41 0 R
/S /Span
>>
endobj
957 0 obj
<<
/ActualText (AZC 0.5)
/K 14
/P 2023 0 R
/Pg 41 0 R
/S /Span
>>
endobj
958 0 obj
<<
/ActualText (AZC 1.0)
/K 15
/P 2024 0 R
/Pg 41 0 R
/S /Span
>>
endobj
959 0 obj
<<
/ActualText (F)
/K 16
/P 2025 0 R
/Pg 41 0 R
/S /Span
>>
endobj
960 0 obj
<<
/K 17
/P 1617 0 R
/Pg 41 0 R
/S /Figure
>>
endobj
961 0 obj
<<
/K 18
/P 1617 0 R
/Pg 41 0 R
/S /Figure
>>
endobj
962 0 obj
<<
/ActualText (pRadd53)
/K 19
/P 2026 0 R
/Pg 41 0 R
/S /Span
>>
endobj
963 0 obj
<<
/ActualText (Radd53)
/K 20
/P 2027 0 R
/Pg 41 0 R
/S /Span
>>
endobj
964 0 obj
<<
/ActualText (Ponceau)
/K 21
/P 2028 0 R
/Pg 41 0 R
/S /Span
>>
endobj
965 0 obj
<<
/ActualText (HU)
/K 22
/P 2029 0 R
/Pg 41 0 R
/S /Span
>>
endobj
966 0 obj
<<
/K 23
/P 1617 0 R
/Pg 41 0 R
/S /Figure
>>
endobj
967 0 obj
<<
/K 24
/P 1617 0 R
/Pg 41 0 R
/S /Figure
>>
endobj
968 0 obj
<<
/ActualText (pRadd53)
/K 25
/P 2030 0 R
/Pg 41 0 R
/S /Span
>>
endobj
969 0 obj
<<
/ActualText (Radd53)
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1133 0 obj
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1134 0 obj
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1135 0 obj
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1156 0 obj
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/K 213
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1157 0 obj
<<
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/K 214
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/K 215
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1159 0 obj
<<
/ActualText (C)
/K 216
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1160 0 obj
<<
/ActualText (25)
/K 217
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1161 0 obj
<<
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/K 218
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1162 0 obj
<<
/ActualText (C)
/K 219
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endobj
1163 0 obj
<<
/ActualText (Glu)
/K 220
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1164 0 obj
<<
/ActualText (Gal)
/K 221
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1165 0 obj
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1166 0 obj
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/K 224
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<<
/K 225
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1169 0 obj
<<
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/K 226
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1170 0 obj
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/K 227
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/K 228
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1172 0 obj
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/K 229
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/K 230
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1175 0 obj
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/K 232
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1176 0 obj
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/ActualText (D)
/K 233
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1177 0 obj
<<
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/K 234
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1178 0 obj
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/K 235
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1179 0 obj
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1180 0 obj
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/K 237
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1181 0 obj
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/K 238
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/ActualText (o)
/K 239
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1183 0 obj
<<
/ActualText (C)
/K 240
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1184 0 obj
<<
/ActualText (Figure 4. Mec1)
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1185 0 obj
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1190 0 obj
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1191 0 obj
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1192 0 obj
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/K 249
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1193 0 obj
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1194 0 obj
<<
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/K 251
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1195 0 obj
<<
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/K 252
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1196 0 obj
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/K 253
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1197 0 obj
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1198 0 obj
<<
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1199 0 obj
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1200 0 obj
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1202 0 obj
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/K 259
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1204 0 obj
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/K 261
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1205 0 obj
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1206 0 obj
<<
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/K 263
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1207 0 obj
<<
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1208 0 obj
<<
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/K 265
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1209 0 obj
<<
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1210 0 obj
<<
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/K 267
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1211 0 obj
<<
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1212 0 obj
<<
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/K 269
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1213 0 obj
<<
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1215 0 obj
<<
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<<
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<<
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1219 0 obj
<<
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<<
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1221 0 obj
<<
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/K 278
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>>
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1222 0 obj
<<
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1223 0 obj
<<
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1224 0 obj
<<
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1226 0 obj
<<
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>>
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<<
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>>
endobj
1228 0 obj
<<
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>>
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1229 0 obj
<<
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<<
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<<
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<<
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1234 0 obj
<<
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<<
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<<
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<<
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<<
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<<
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<<
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1241 0 obj
<<
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1242 0 obj
<<
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>>
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1243 0 obj
<<
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endobj
1244 0 obj
<<
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/K 301
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>>
endobj
1245 0 obj
<<
/ActualText (HU or 0.05% MMS at )
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endobj
1246 0 obj
<<
/ActualText (25)
/K 303
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1247 0 obj
<<
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endobj
1248 0 obj
<<
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/K 305
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endobj
1249 0 obj
<<
/ActualText (kd)
/K 306
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endobj
1250 0 obj
<<
/ActualText (: )
/K 307
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endobj
1251 0 obj
<<
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/K 308
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>>
endobj
1252 0 obj
<<
/ActualText (-)
/K 309
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1253 0 obj
<<
/ActualText
/K 310
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>>
endobj
1254 0 obj
<<
/ActualText (G.)
/K 311
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1255 0 obj
<<
/ActualText (Sml1 Western blot analysis \(Experimental Procedures\) was performed on WT cells in log )
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/S /Span
>>
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<<
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>>
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<<
/ActualText (MMS. All incubations were at)
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>>
endobj
1258 0 obj
<<
/ActualText (30)
/K 315
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1259 0 obj
<<
/ActualText (o)
/K 316
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endobj
1260 0 obj
<<
/ActualText (C.)
/K 317
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>>
endobj
1261 0 obj
<<
/ActualText (H.)
/K 318
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>>
endobj
1262 0 obj
<<
/ActualText (Model: Mec1 )
/K 319
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>>
endobj
1263 0 obj
<<
/ActualText (signaling)
/K 320
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>>
endobj
1264 0 obj
<<
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>>
endobj
1265 0 obj
<<
/ActualText (proteotoxic)
/K 322
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>>
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<<
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>>
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<<
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>>
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1268 0 obj
<<
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>>
endobj
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<<
/ActualText (Sml1 species required for survival. Solid lines: links inferred based on findings above. )
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>>
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1270 0 obj
<<
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>>
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1271 0 obj
<<
/ActualText (response. Green: canonical checkpoint)
/K 328
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>>
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1272 0 obj
<<
/ActualText (response. )
/K 329
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endobj
1273 0 obj
<<
/K 0
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>>
endobj
1274 0 obj
<<
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/K 1
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endobj
1275 0 obj
<<
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/K 2
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1276 0 obj
<<
/ActualText (Saez al Figure )
/K 3
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>>
endobj
1277 0 obj
<<
/ActualText (S1)
/K 4
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>>
endobj
1278 0 obj
<<
/K 5
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/S /Figure
>>
endobj
1279 0 obj
<<
/K 6
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/S /Figure
>>
endobj
1280 0 obj
<<
/K 7
/P 1618 0 R
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/S /Figure
>>
endobj
1281 0 obj
<<
/ActualText (mec1)
/K 8
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>>
endobj
1282 0 obj
<<
/ActualText (ts)
/K 9
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>>
endobj
1283 0 obj
<<
/ActualText (::NAT)
/K 10
/P 2176 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1284 0 obj
<<
/ActualText (viable deletion )
/K 11
/P 2177 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1285 0 obj
<<
/ActualText (library )
/K 12
/P 2177 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1286 0 obj
<<
/ActualText
/K 13
/P 2178 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1287 0 obj
<<
/ActualText (X)
/K 14
/P 2179 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1288 0 obj
<<
/K 15
/P 1618 0 R
/Pg 42 0 R
/S /Figure
>>
endobj
1289 0 obj
<<
/ActualText (mec1)
/K 16
/P 2180 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1290 0 obj
<<
/ActualText (ts)
/K 17
/P 2180 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1291 0 obj
<<
/ActualText
/K 18
/P 2180 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1292 0 obj
<<
/ActualText (mec1)
/K 19
/P 2181 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1293 0 obj
<<
/K 20
/P 2181 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1294 0 obj
<<
/ActualText (ts)
/K 21
/P 2181 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1295 0 obj
<<
/ActualText (::NAT)
/K 22
/P 2181 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1296 0 obj
<<
/ActualText (+)
/K 23
/P 2182 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1297 0 obj
<<
/ActualText
/K 24
/P 2183 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1298 0 obj
<<
/K 25
/P 2183 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1299 0 obj
<<
/ActualText (+)
/K 26
/P 2184 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1300 0 obj
<<
/K 27
/P 1618 0 R
/Pg 42 0 R
/S /Figure
>>
endobj
1301 0 obj
<<
/ActualText (A)
/K 28
/P 2185 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1302 0 obj
<<
/ActualText (Unchallenged growth at )
/K 29
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1303 0 obj
<<
/ActualText (26)
/K 30
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1304 0 obj
<<
/ActualText (o)
/K 31
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1305 0 obj
<<
/ActualText (C)
/K 32
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1306 0 obj
<<
/ActualText (, 30)
/K 33
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1307 0 obj
<<
/ActualText (o)
/K 34
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1308 0 obj
<<
/ActualText (C, )
/K 35
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1309 0 obj
<<
/ActualText (or )
/K 36
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1310 0 obj
<<
/ActualText (33)
/K 37
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1311 0 obj
<<
/ActualText (o)
/K 38
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1312 0 obj
<<
/ActualText (C )
/K 39
/P 2186 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1313 0 obj
<<
/ActualText (Heterozygote)
/K 40
/P 2187 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1314 0 obj
<<
/ActualText (Diploids)
/K 41
/P 2188 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1315 0 obj
<<
/ActualText (Haploid )
/K 42
/P 2189 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1316 0 obj
<<
/ActualText (double )
/K 43
/P 2190 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1317 0 obj
<<
/ActualText (mutants)
/K 44
/P 2191 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1318 0 obj
<<
/ActualText (Assessment )
/K 45
/P 2192 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1319 0 obj
<<
/ActualText (of genetic)
/K 46
/P 2193 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1320 0 obj
<<
/ActualText (interaction)
/K 47
/P 2194 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1321 0 obj
<<
/K 48
/P 1618 0 R
/Pg 42 0 R
/S /Figure
>>
endobj
1322 0 obj
<<
/ActualText (Figure S1. Synthetic Genetic Array \(SGA\) analysis of )
/K 49
/P 2195 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1323 0 obj
<<
/ActualText (mec1)
/K 50
/P 2195 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1324 0 obj
<<
/ActualText (-)
/K 51
/P 2195 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1325 0 obj
<<
/ActualText (4)
/K 52
/P 2195 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1326 0 obj
<<
/ActualText (.)
/K 53
/P 2195 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1327 0 obj
<<
/ActualText (A.)
/K 54
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1328 0 obj
<<
/ActualText (SGA analysis of )
/K 55
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1329 0 obj
<<
/ActualText (mec1)
/K 56
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1330 0 obj
<<
/ActualText (-)
/K 57
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1331 0 obj
<<
/ActualText (4 )
/K 58
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1332 0 obj
<<
/ActualText (was performed as described )
/K 59
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1333 0 obj
<<
/ActualText (\(Baryshnikova )
/K 60
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1334 0 obj
<<
/ActualText (et al., 2010\). Briefly, a )
/K 61
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1335 0 obj
<<
/ActualText (mec1)
/K 62
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1336 0 obj
<<
/ActualText (-)
/K 63
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1337 0 obj
<<
/ActualText (4::NatMX )
/K 64
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1338 0 obj
<<
/ActualText (query strain was constructed and crossed with a viable deletion library )
/K 65
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1339 0 obj
<<
/ActualText (marked with )
/K 66
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1340 0 obj
<<
/ActualText (KanMX. )
/K 67
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1341 0 obj
<<
/ActualText (The resulting diploids were sporulated and selected for )
/K 68
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1342 0 obj
<<
/ActualText (MATa )
/K 69
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1343 0 obj
<<
/ActualText (double )
/K 70
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1344 0 obj
<<
/ActualText (mutant haploids carrying both )
/K 71
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1345 0 obj
<<
/ActualText (mec1)
/K 72
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1346 0 obj
<<
/ActualText (-)
/K 73
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1347 0 obj
<<
/ActualText (4::NatMX )
/K 74
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1348 0 obj
<<
/ActualText (and a deletion mutation. Fitness of each )
/K 75
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1349 0 obj
<<
/ActualText (double mutant was compared to both a )
/K 76
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1350 0 obj
<<
/ActualText (mec1)
/K 77
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1351 0 obj
<<
/ActualText (-)
/K 78
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1352 0 obj
<<
/ActualText (4 )
/K 79
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1353 0 obj
<<
/ActualText (or the corresponding single deletion mutant )
/K 80
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1354 0 obj
<<
/ActualText (on 2% )
/K 81
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1355 0 obj
<<
/ActualText (glucose synthetic )
/K 82
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1356 0 obj
<<
/ActualText (complete medium agar plates at 26)
/K 83
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1357 0 obj
<<
/ActualText (o)
/K 84
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1358 0 obj
<<
/ActualText (C, 30)
/K 85
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1359 0 obj
<<
/ActualText (o)
/K 86
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1360 0 obj
<<
/ActualText (C, and 33)
/K 87
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1361 0 obj
<<
/ActualText (o)
/K 88
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1362 0 obj
<<
/ActualText (C and positive)
/K 89
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1363 0 obj
<<
/ActualText (-)
/K 90
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1364 0 obj
<<
/ActualText (or negative)
/K 91
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1365 0 obj
<<
/ActualText (-)
/K 92
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1366 0 obj
<<
/ActualText (interaction was assessed as described )
/K 93
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1367 0 obj
<<
/ActualText (\(Baryshnikova )
/K 94
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1368 0 obj
<<
/ActualText (et al., 2010\).)
/K 95
/P 2196 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1369 0 obj
<<
/ActualText (B.)
/K 96
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1370 0 obj
<<
/ActualText (Number of )
/K 97
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1371 0 obj
<<
/ActualText (mec1)
/K 98
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1372 0 obj
<<
/ActualText (-)
/K 99
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1373 0 obj
<<
/ActualText (4 )
/K 100
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1374 0 obj
<<
/ActualText (genetic )
/K 101
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1375 0 obj
<<
/ActualText (interactors )
/K 102
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1376 0 obj
<<
/ActualText (identified at the indicated temperature)
/K 103
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1377 0 obj
<<
/ActualText (. )
/K 104
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1378 0 obj
<<
/ActualText (Blue and red )
/K 105
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1379 0 obj
<<
/ActualText (bars represent negative)
/K 106
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1380 0 obj
<<
/ActualText (-)
/K 107
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1381 0 obj
<<
/ActualText (and positive)
/K 108
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1382 0 obj
<<
/ActualText (-)
/K 109
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1383 0 obj
<<
/ActualText (interactors, respectively)
/K 110
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1384 0 obj
<<
/ActualText (. )
/K 111
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1385 0 obj
<<
/ActualText (To minimise inclusion of false )
/K 112
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1386 0 obj
<<
/ActualText (positives, )
/K 113
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1387 0 obj
<<
/ActualText (we took advantage of the quantitative nature of the SGA analysis, and limited our )
/K 114
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1388 0 obj
<<
/ActualText (analysis to the 200 strongest positive)
/K 115
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1389 0 obj
<<
/ActualText (-)
/K 116
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1390 0 obj
<<
/ActualText (and the 200 strongest positive)
/K 117
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1391 0 obj
<<
/ActualText (-)
/K 118
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1392 0 obj
<<
/ActualText (interactors.)
/K 119
/P 2197 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1393 0 obj
<<
/K 120
/P 2198 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1394 0 obj
<<
/ActualText (0)
/K 121
/P 2199 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1395 0 obj
<<
/ActualText (200)
/K 122
/P 2200 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1396 0 obj
<<
/ActualText (400)
/K 123
/P 2201 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1397 0 obj
<<
/ActualText (600)
/K 124
/P 2202 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1398 0 obj
<<
/ActualText (800)
/K 125
/P 2203 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1399 0 obj
<<
/ActualText (1000)
/K 126
/P 2204 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1400 0 obj
<<
/ActualText (1200)
/K 127
/P 2205 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1401 0 obj
<<
/ActualText (1400)
/K 128
/P 2206 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1402 0 obj
<<
/ActualText
/K 129
/P 2207 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1403 0 obj
<<
/ActualText
/K 130
/P 2208 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1404 0 obj
<<
/ActualText
/K 131
/P 2209 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1405 0 obj
<<
/ActualText
/K 132
/P 2210 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1406 0 obj
<<
/ActualText
/K 133
/P 2211 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1407 0 obj
<<
/ActualText
/K 134
/P 2212 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1408 0 obj
<<
/K 135
/P 2198 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1409 0 obj
<<
/ActualText (-)
/K 136
/P 2213 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1410 0 obj
<<
/K 137
/P 2198 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1411 0 obj
<<
/ActualText (+)
/K 138
/P 2214 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1412 0 obj
<<
/ActualText (B)
/K 139
/P 2215 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1413 0 obj
<<
/ActualText (No. of )
/K 140
/P 2216 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1414 0 obj
<<
/ActualText (mec1)
/K 141
/P 2216 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1415 0 obj
<<
/ActualText (-)
/K 142
/P 2216 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1416 0 obj
<<
/ActualText (4 )
/K 143
/P 2216 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1417 0 obj
<<
/ActualText (interactors)
/K 144
/P 2217 0 R
/Pg 42 0 R
/S /Span
>>
endobj
1418 0 obj
<<
/K 145
/P 1618 0 R
/Pg 42 0 R
/S /Figure
>>
endobj
1419 0 obj
<<
/K 0
/P 1619 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1420 0 obj
<<
/ActualText (Corcoles)
/K 1
/P 2218 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1421 0 obj
<<
/ActualText (-)
/K 2
/P 2218 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1422 0 obj
<<
/ActualText (Saez al Figure S2)
/K 3
/P 2218 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1423 0 obj
<<
/ActualText (A)
/K 4
/P 2219 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1424 0 obj
<<
/K 5
/P 1619 0 R
/Pg 43 0 R
/S /Figure
>>
endobj
1425 0 obj
<<
/K 6
/P 1619 0 R
/Pg 43 0 R
/S /Figure
>>
endobj
1426 0 obj
<<
/K 7
/P 1619 0 R
/Pg 43 0 R
/S /Figure
>>
endobj
1427 0 obj
<<
/ActualText (WT)
/K 8
/P 2220 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1428 0 obj
<<
/ActualText (m)
/K 9
/P 2221 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1429 0 obj
<<
/ActualText (ec1)
/K 10
/P 2221 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1430 0 obj
<<
/ActualText (-)
/K 11
/P 2221 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1431 0 obj
<<
/ActualText (4)
/K 12
/P 2221 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1432 0 obj
<<
/ActualText (atg1)
/K 13
/P 2222 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1433 0 obj
<<
/ActualText
/K 14
/P 2222 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1434 0 obj
<<
/ActualText (m)
/K 15
/P 2223 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1435 0 obj
<<
/ActualText (ec1)
/K 16
/P 2223 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1436 0 obj
<<
/ActualText (-)
/K 17
/P 2223 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1437 0 obj
<<
/ActualText (4 )
/K 18
/P 2223 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1438 0 obj
<<
/ActualText (atg1)
/K 19
/P 2224 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1439 0 obj
<<
/ActualText
/K 20
/P 2224 0 R
/Pg 43 0 R
/S /Span
>>
endobj
1440 0 obj
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